FlyBase Gene Report: Dmel\Cyt-c-p

General Information

Symbol

Dmel\Cyt-c-p

Species

D. melanogaster

Name

Cytochrome c proximal

Annotation Symbol

CG17903

Feature Type

protein_coding_gene

FlyBase ID

FBgn0284248

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (UniProt, P84029)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

cytochrome c, DC4, Cyt c, Cyt-c2, Cytc

Key Links

Genomic Location

Cytogenetic map

36A11-36A12

Sequence location

2L:16,719,932..16,722,644 [+]

Recombination map

2-52

RefSeq locus

NT_033779 REGION:16719932..16722644

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables electron transfer activity

inferred from direct assay

(Limbach and Wu, 1985)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables electron transfer activity

inferred from electronic annotation with InterPro:IPR002327, InterPro:IPR009056, InterPro:IPR036909

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

enables heme binding

inferred from electronic annotation with InterPro:IPR002327, InterPro:IPR009056, InterPro:IPR036909

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

involved_in mitochondrial electron transport, ubiquinol to cytochrome c

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

involved_in oxidative phosphorylation

inferred from sequence or structural similarity with SGD:S000003809

(Limbach and Wu, 1985)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Challa et al., 2007, Tenev et al., 2002)

located_in mitochondrion

inferred from direct assay

(Yano et al., 2006, Dorstyn et al., 2004, Morrow et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrial intermembrane space

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

located_in mitochondrial intermembrane space

inferred from sequence or structural similarity with UniProtKB:P00044

(Limbach and Wu, 1985)

Gene Group (FlyBase)

CYTOCHROME C

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION

Protein Family (UniProt)

Belongs to the cytochrome c family. (P84029)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOCHROME C -: Cytochrome c is a nuclear-encoded mitochondrial protein involved in electron transfer as part of the mitochondrial electron transport chain. Cytochrome c is located in the mitochondrial intermembrane space and functions as a single electron carrier from ubiquinol-cytochrome c reductase complex to Cytochrome c oxidase. (Adapted from PMID:21296189).

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION -: Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)

Protein Function (UniProtKB)

(UniProt, P84029)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Cyt-c1 and Cyt-c2: Cytochrome c

Apparently the structural genes for two cytochrome-c type enzymes, which differ from each other in 32/107 amino-acid residues. Cyt-c1 (sequence D3) expressed at constant, but relatively low, level throughout development; Cyt-c2 (sequence D4) expressed at varying, but relatively high, levels throughout development. Amino acid sequence also given in Handbook of Biochemistry and Molecular Biology: Proteins (Fasman, ed.) CRC Press, Cleveland, Vol. 3, pp. 282-83.

Summary (Interactive Fly)

electron transport - caspase activation during apoptosis D

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyt-c-p for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P84029)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyt-c-p-RA

FBtr0080889

NM_057828

681

108

Cyt-c-p-RB

FBtr0344849

NM_001299055

634

108

Additional Transcript Data and Comments

Reported size (kB)

0.9 (northern blot)

(Limbach and Wu, 1985, Swanson et al., 1985)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyt-c-p-PA

FBpp0080446

11.7

108

10.18

FBpp0311164

11.7

108

10.18

P84029

NP_001285984

AHN54498

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

108 aa isoforms: Cyt-c-p-PA, Cyt-c-p-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

107 (aa); 12.2 (kD)

(Inoue et al., 1986)

108 (aa)

(Limbach and Wu, 1985, Swanson et al., 1985)

Comments

External Data

Post Translational Modification

Binds 1 heme c group covalently per subunit.

(UniProt, P84029)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyt-c-p using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyt-c-p_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | intense | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

(Limbach and Wu, 1985)

adult stage

adult thorax

(Limbach and Wu, 1985)

adult head

(Limbach and Wu, 1985)

adult abdomen

(Limbach and Wu, 1985)

Additional Descriptive Data

Cyt-c-p-XR expression fluctuates through development, with highest levels in first instar larvae and adult. Among adult body parts examined, Cyt-c-p-XR expression is highest in the thorax.

(Limbach and Wu, 1985)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Cyt-c-p protein levels were determined by a biochemical assay. Protein levels rise through the larval stages with a small peak at pupation. A six-fold increase is seen at adult emergence.

(Inoue et al., 1986)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Challa et al., 2007, Tenev et al., 2002)

located_in mitochondrion

inferred from direct assay

(Yano et al., 2006, Dorstyn et al., 2004, Morrow et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyt-c-p in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyt-c-p

View exonic expression by tissue for Dmel\Cyt-c-p

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34996/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0284248

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000409

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0284248

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17903

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyt-c-p

Transgenic constructs containing regulatory region of Cyt-c-p

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2L)cact-255rv64

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)Exel6039

(Ryder, 2004.4.26)

Df(2L)Exel7066

(Ryder, 2004.4.26)

Df(2L)glu-17C

(Kahsai et al., 2016, Cobbe et al., 2006)

Df(2L)H20

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2L)r10

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)Exel6039)

Cyt-c-p^k13905

lethal (with Df(2L)glu-17C)

Cyt-c-p^k13905

lethal | recessive

Cyt-c-p^k13905

lethal - all die before end of first instar larval stage

Cyt-c-p^k13905

lethal - all die during embryonic stage (with Df(2L)H20)

Cyt-c-p^k13905

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyt-c-p^GD9483

viable, with Scer\GAL4^pnr-MD237

Cyt-c-p^GD9483

viable, with Scer\GAL4^tin.CΔ4

Cyt-c-p^GD9483

Other Phenotypes

Allele

some die during embryonic stage (with Df(2L)H20)

Cyt-c-p^k13905

some die during first instar larval stage

Cyt-c-p^k13905

visible, with Scer\GAL4^pnr-MD237

Cyt-c-p^GD9483

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

Cyt-c-p^HMC05771

Phenotype manifest in

Allele

eye, with Scer\GAL4^eya.enh1+E+2

Cyt-c-p^HMC05771

mesonotum, with Scer\GAL4^pnr-MD237

Cyt-c-p^GD9483

trichogen cell, with Scer\GAL4^pnr-MD237

Cyt-c-p^GD9483

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\CYCS

13 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Cycs

13 of 14

Yes

Rnor\LOC100363502

13 of 14

Yes

Rnor\Cyct

10 of 14

Yes

Rnor\LOC690675

10 of 14

Yes

Rnor\RGD1562558

6 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Cycs

13 of 14

Yes

Mmus\Cyct

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cycs

11 of 13

Yes

Xtro\cyct

10 of 13

Yes

Xtro\clint1

1 of 13

Xtro\tkt

1 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\cycsb

13 of 14

Yes

Drer\cycsa

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\cyc-2.1

13 of 14

Yes

Cele\cyc-2.2

13 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP009537

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\CYTC-1

12 of 13

Yes

Atha\CYTC-2

12 of 13

Yes

Atha\ABCI20

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CYC1

12 of 13

Yes

Scer\CYC7

11 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyc1

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyt-c-p. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Cyt-c-d

11 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CYCS; cytochrome c, somatic

model of thrombocytopenia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYCS; cytochrome c, somatic

13 of 14

123970

THROMBOCYTOPENIA 4; THC4

thrombocytopenia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cyt-c-p - Adh

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Argk1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - CG7148

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Cs1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Gpdh1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Hsap\UQCRC1

proximity ligation assay, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, western blot

(Hung et al., 2021)

Cyt-c-p - Mf

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Mlc1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Mlc2

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Prm

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Scp1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - SkpA

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - SkpB

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Tm2

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - Tppl

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - UQCR-C1

proximity ligation assay, fluorescence microscopy, inferred by author

(Hung et al., 2021)

Cyt-c-p - mAcon1

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - up

experimental knowledge based

(Guruharsha et al., 2011)

Cyt-c-p - wupA

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cyt-c-p

suppressible

Cyt-c-d

(Arama et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cyt-c-d

suppressible

Cyt-c-p

(Arama et al., 2006)

peb

suppressible

Cyt-c-p

(Wilk et al., 2004)

External Data

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

34996

MIST (protein-protein) - An integrated Molecular Interaction Database

34996

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

OXIDATIVE PHOSPHORYLATION

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Respiratory electron transport

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-52

Cytogenetic map

36A11-36A12

Sequence location

2L:16,719,932..16,722,644 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36A11-36A12

Limits computationally determined from genome sequence between P{EP}grp^EP921&P{lacW}l(2)k13905^k13905 and P{lacW}glu^k08819

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36A10-36A11

(determined by in situ hybridisation)

(Spradling et al., 1999, Limbach and Wu, 1985)

36A10-36A11

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-52

(FlyBase, 2016)

2-51.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

11115

y¹ w^67c23; P{lacW}Cyt-c-p^k13905/CyO

64898

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05771}attP40

Kyoto

125170

w¹¹¹⁸; P{RS5}Cyt-c-p^5-HA-1262

111334

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}Cyt-c-p^k13905 P{neoFRT}40A/CyO y⁺

NIG-Fly

M2L-0786

y¹ w¹¹¹⁸; Cyt-c-p^SK7 P{neoFRT}40A/CyO-Tb

M2L-0787

y¹ w¹¹¹⁸; Cyt-c-p^SK8 P{neoFRT}40A/CyO-Tb

2LG-0623

y² VhaAC39-1^cho-1 v¹; P{U6-Cyt-c-p.NIG.sgRNA}attP40/CyO

VDRC

v106759

P{KK108087}VIE-260B

v33019

w¹¹¹⁸; P{GD9483}v33019

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (187)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH17228

Other clones

DPiM_RH17228

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Cyt-c-p is neither necessary nor sufficient for caspase activation and apoptosis in Drosophila cells.

(Dorstyn et al., 2004)

Mutating the invariant proline-30 of Cyt-c-p to alanine destabilizes the haem crevice more than the overall conformation.

(Koshy et al., 1990)

The Cyt-c-p protein was detected as a functional cytochrome molecule and the amino acid sequence determined.

(Inoue et al., 1986)

Cyt-c-p encodes a functional cytochrome c protein. Cyt-c-p is expressed at varying relatively high levels throughout development and the predicted polypeptide sequence differs from Cyt-c-d at 32 amino acid residues. Cyt-c-d and Cyt-c-p are located 3.5kb apart and have arisen from an ancient duplication event.

(Limbach and Wu, 1985)

A cDNA clone for the thoracic muscle cytochrome c gene from M.sexta has been used to isolate the corresponding major thoracic muscle cytochrome c gene from D.melanogaster. Hybridisation studies reveal that Cyt-c-p is expressed at constant high levels. The genomic clone has been sequenced and its amino acid sequence derived. Cyt-c-d shares limited nucleotide homology with Cyt-c-p.

(Swanson et al., 1985)

Apparently the structural gene for one of two cytochrome-c type enzymes, which differ from each other in 32/107 amino-acid residues. First isolated from a Charon-4 library using mouse cytochrome-c gene sequence as a probe. Cyt-c-d (sequence D3) expressed at constant, but relatively low, level throughout development; Cyt-c-p (sequence D4) expressed at varying, but relatively high, levels throughout development. Amino acid sequence also given in Fasman (1977).

Relationship to Other Genes

Source for database merge of

Source for merge of: Cyt-c-p l(2)k13905

(Kahsai et al., 2016, Arama et al., 2003)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cyt-c2 CG17903

(Nelson, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (37)

Reported As

Symbol Synonym

CG17903

(Curcio et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Perez-Gomez et al., 2020, Hosono et al., 2015, Laslo et al., 2013, Cammarato et al., 2011, Tiefenböck et al., 2010, Baltzer et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Caggese et al., 2006, Yu et al., 2004, Pile et al., 2003)

CYC

(Caggese et al., 2006)

CYC2

(Liu et al., 2018)

Cyct-c-p

(Baltzer et al., 2009)

Cyt C

(Grant et al., 2010)

Cyt c

(de Castro et al., 2013, Wang et al., 2011, Abdelwahid et al., 2007, Challa et al., 2007)

Cyt-c

(Ogneva et al., 2016)

Cyt-c-P

(Palu et al., 2019)

Cyt-c2

(Furlong et al., 2001, Leemans et al., 2000)

CytC

(Zhang et al., 2013)

CytC-2

Cytc

(Perez-Gomez et al., 2020, Shaik et al., 2012, Meier et al., 2000)

Cytc-p

(Dorstyn et al., 2004)

DC4

(Dorstyn et al., 2004, Varkey et al., 1999, Inoue et al., 1986, Limbach and Wu, 1985)

DMc01

(Koshy et al., 1990)

P84029

(Ebanks et al., 2021)

cyt c

(Jiang et al., 2020, von Stockum et al., 2011, Haghnia et al., 2007)

cyt c-p

(Kuranaga and Miura, 2007)

cyt-c-p

(Peterson et al., 2007, Arama et al., 2006, Mendes et al., 2006, Arama and Steller, 2005, Kornbluth and White, 2005, Baehrecke, 2003)

cyt-c2

(Zou et al., 2000)

cyt.c

(Rodriguez et al., 1999)

cytC-p

(Álvarez-Fernández et al., 2015)

cytochrome c

(Walker and Benzer, 2004)

dCyt.C-p

(Banerjee et al., 2013)

dc4

(Means et al., 2006, Dorstyn et al., 2004)

l(2)k13905

(Kahsai et al., 2016)

pDMc01

(Swanson et al., 1985)

Name Synonyms

Cytochrome C

(Tripoli et al., 2005, White, 1999)

Cytochrome c

(Li et al., 2021, Shaik et al., 2012, Shepherd and Dailey, 2009, Caggese et al., 2006, Tripoli et al., 2005, Danial and Korsmeyer, 2004)

Cytochrome c proximal

(Cammarato et al., 2011, Buffin and Gho, 2010, Xun et al., 2009)

Cytochrome-c-proximal

(Baltzer et al., 2009)

cytochrome C

(Means et al., 2006, Igaki and Miura, 2004)

cytochrome c DC4

(Zimmermann et al., 2002)

cytochrome c proximal

(Laslo et al., 2013)

cytochrome-c-p

(Peterson et al., 2007)

lethal (2) k13905

Secondary FlyBase IDs

FBgn0000409
FBgn0021867

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34996

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P84029

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P84029

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2J6D4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P84029

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34996/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0284248

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0284248

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17903

MARRVEL_MODEL - MARRVEL (model organism gene)

34996

Linkouts

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

4272

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyt-c-p_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000409

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0284248

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17903

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005841

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

34996

MIST (protein-protein) - An integrated Molecular Interaction Database

34996

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Respiratory electron transport

References (147)

The following external sites may use different assemblies or annotations than FlyBase.

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