FlyBase Gene Report: Dmel\Cyt-c-d

General Information

Symbol

Dmel\Cyt-c-d

Species

D. melanogaster

Name

Cytochrome c distal

Annotation Symbol

CG13263

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086907

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (UniProt, P04657)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

cytochrome c, bln, DC3, Cyt c, blanks

Key Links

Genomic Location

Cytogenetic map

36A11-36A11

Sequence location

2L:16,715,891..16,719,635 [+]

Recombination map

2-52

RefSeq locus

NT_033779 REGION:16715891..16719635

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cysteine-type endopeptidase activator activity involved in apoptotic process

inferred from mutant phenotype

(Arama et al., 2006, Arama et al., 2003)

enables electron transfer activity

inferred from direct assay

(Limbach and Wu, 1985)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables electron transfer activity

inferred from electronic annotation with InterPro:IPR002327, InterPro:IPR009056, InterPro:IPR036909

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

enables heme binding

inferred from electronic annotation with InterPro:IPR002327, InterPro:IPR009056, InterPro:IPR036909

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in regulation of compound eye retinal cell programmed cell death

inferred from mutant phenotype

(Mendes et al., 2006)

involved_in sperm individualization

inferred from mutant phenotype

(Arama et al., 2006, Arama et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

involved_in mitochondrial electron transport, ubiquinol to cytochrome c

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

involved_in oxidative phosphorylation

inferred from sequence or structural similarity with SGD:S000003809

(Limbach and Wu, 1985)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Challa et al., 2007, Tenev et al., 2002)

located_in mitochondrion

inferred from direct assay

(Yano et al., 2006, Dorstyn et al., 2004, Morrow et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrial intermembrane space

inferred from biological aspect of ancestor with PANTHER:PTN000238899

(GO Reference Genome Project, 2011-)

located_in mitochondrial intermembrane space

inferred from sequence or structural similarity with UniProtKB:P00044

(Limbach and Wu, 1985)

Gene Group (FlyBase)

CYTOCHROME C

Protein Family (UniProt)

Belongs to the cytochrome c family. (P04657)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOCHROME C -: Cytochrome c is a nuclear-encoded mitochondrial protein involved in electron transfer as part of the mitochondrial electron transport chain. Cytochrome c is located in the mitochondrial intermembrane space and functions as a single electron carrier from ubiquinol-cytochrome c reductase complex to Cytochrome c oxidase. (Adapted from PMID:21296189).

Protein Function (UniProtKB)

(UniProt, P04657)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Cyt-c1 and Cyt-c2: Cytochrome c

Apparently the structural genes for two cytochrome-c type enzymes, which differ from each other in 32/107 amino-acid residues. Cyt-c1 (sequence D3) expressed at constant, but relatively low, level throughout development; Cyt-c2 (sequence D4) expressed at varying, but relatively high, levels throughout development. Amino acid sequence also given in Handbook of Biochemistry and Molecular Biology: Proteins (Fasman, ed.) CRC Press, Cleveland, Vol. 3, pp. 282-83.

Summary (Interactive Fly)

electron transport - caspase activation during apoptosis D

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyt-c-d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P04657)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyt-c-d-RA

FBtr0080888

NM_057816

837

105

Cyt-c-d-RB

FBtr0335141

NM_001273580

767

105

Additional Transcript Data and Comments

Reported size (kB)

2.1 (northern blot)

(Limbach and Wu, 1985)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyt-c-d-PA

FBpp0080445

11.4

105

9.95

FBpp0307140

11.4

105

9.95

P04657

NP_001260509

AGB93044

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

105 aa isoforms: Cyt-c-d-PA, Cyt-c-d-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

105 (aa)

(Limbach and Wu, 1985)

Comments

External Data

Post Translational Modification

Binds 1 heme c group covalently per subunit.

(UniProt, P04657)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyt-c-d using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.85

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

(Limbach and Wu, 1985)

adult stage

adult thorax

(Limbach and Wu, 1985)

adult head

(Limbach and Wu, 1985)

adult abdomen

(Limbach and Wu, 1985)

adult stage | male

organism

(Arama et al., 2003)

Additional Descriptive Data

Cyt-c-d-XR is expressed at a low and steady level in all developmental stages and all adult body parts examined.

(Limbach and Wu, 1985)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Challa et al., 2007, Tenev et al., 2002)

located_in mitochondrion

inferred from direct assay

(Yano et al., 2006, Dorstyn et al., 2004, Morrow et al., 2000)

Expression Deduced from Reporters

Reporter: P{PZ}Cyt-c-d^bln1

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larval brain

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyt-c-d in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyt-c-d

View exonic expression by tissue for Dmel\Cyt-c-d

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086907

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34995/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086907

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086907

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13263

Flygut - An atlas of the Drosophila adult midgut

FBgn0086907

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyt-c-d

Transgenic constructs containing regulatory region of Cyt-c-d

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene not disrupted in

Df(2L)r10

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)rd9

(Roote, 1997.8.13)

Gene disrupted in

Df(2L)Exel6039

(Ryder, 2004.4.26)

Df(2L)Exel7066

(Ryder, 2004.4.26)

Df(2L)H20

(Castrillon et al., 1993)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyt-c-d^GD7970

viable, with Scer\GAL4^Mef2.PR

Cyt-c-d^GD7970

viable, with Scer\GAL4^pnr-MD237

Cyt-c-d^GD7970

viable, with Scer\GAL4^tin.CΔ4

Cyt-c-d^GD7970

viable (with Cyt-c-d^EP2049)

Cyt-c-d^EP2305

viable (with Cyt-c-d^EP2305)

Cyt-c-d^EP2049

viable (with Df(2L)H20)

Cyt-c-d^EP2049

Sterility

Allele

male semi-sterile

Cyt-c-d^EP2049

male semi-sterile (with Cyt-c-d^EP2049)

Cyt-c-d^EP2305

male semi-sterile (with Cyt-c-d^EP2305)

Cyt-c-d^EP2049

male sterile

male sterile (with Df(2L)H20)

male sterile | recessive

Cyt-c-d^bln1

Other Phenotypes

Allele

visible

Cyt-c-d^Z21091

Phenotype manifest in

Allele

major mitochondrial derivative

Cyt-c-d^bln1

minor mitochondrial derivative

Cyt-c-d^bln1

posterior scutellar bristle | increased number

Cyt-c-d^Z21091

secondary pigment cell

secondary pigment cell (with Df(2L)H20)

Cyt-c-d^Z21091

spermatid

spermatid axoneme

Cyt-c-d^bln1

tertiary pigment cell

tertiary pigment cell (with Df(2L)H20)

Cyt-c-d^Z21091

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\CYCS

8 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Cycs

8 of 14

Yes

Rnor\LOC100363502

8 of 14

Yes

Rnor\Cyct

6 of 14

Rnor\LOC690675

6 of 14

Rnor\RGD1562558

6 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Cycs

8 of 14

Yes

Mmus\Cyct

6 of 14

Xenopus tropicalis (Western clawed frog) (3)

Xtro\cycs

6 of 13

Yes

Xtro\cyct

6 of 13

Yes

Xtro\tkt

1 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\cycsb

7 of 14

Yes

Drer\cycsa

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\cyc-2.1

11 of 14

Yes

Cele\cyc-2.2

10 of 14

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP009537

6 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\CYTC-1

11 of 13

Yes

Atha\CYTC-2

11 of 13

Yes

Atha\ABCI20

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CYC1

11 of 13

Yes

Scer\CYC7

10 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyc1

7 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyt-c-d. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Cyt-c-p

11 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CYCS; cytochrome c, somatic

model of thrombocytopenia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Cyt-c-d^EP2305

ameliorates severe acute respiratory syndrome

modeled by HCoV-SARS\3a^{UAS.CUHK-W1.EGFP}

(Wong et al., 2005)

ameliorates Coronavirus infectious disease

modeled by HCoV-SARS\M^{UAS.CUHK-Su10}

(Chan et al., 2007)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYCS; cytochrome c, somatic

8 of 14

123970

THROMBOCYTOPENIA 4; THC4

thrombocytopenia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cyt-c-d

suppressible

Cyt-c-p

(Arama et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cyt-c-p

suppressible

Cyt-c-d

(Arama et al., 2006)

suppressible

(Ida et al., 2009)

suppressible

(Yang et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61002

DroID - A comprehensive database of gene and protein interactions.

FBgn0086907

MIST (genetic) - An integrated Molecular Interaction Database

34995

MIST (protein-protein) - An integrated Molecular Interaction Database

34995

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-52

Cytogenetic map

36A11-36A11

Sequence location

2L:16,715,891..16,719,635 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36A11-36A11

Limits computationally determined from genome sequence between P{EP}grp^EP921&P{lacW}l(2)k13905^k13905 and P{lacW}glu^k08819

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36A1-36B6

(determined by in situ hybridisation)

(Spradling et al., 1999)

36A1-36B6

(BDGP Project Members, 1994-1999)

36A10-36A11

(determined by in situ hybridisation)

(Limbach and Wu, 1985)

Experimentally Determined Recombination Data

Location

2-52

(FlyBase, 2016)

2-51.2

(Comeron et al., 2012)

2-[52]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

57853

y¹ v¹; P{TRiP.HMJ21900}attP40/CyO

56348

y¹ w^*; Mi{MIC}Cyt-c-d^MI11583

11763

P{PZ}Cyt-c-d^bln1 CG31808^bln-1 cn¹/CyO; ry⁵⁰⁶

FlyORF

F002625

M{UAS-Cyt-c-d.ORF.3xHA.GW}ZH-86Fb

Korea

11513

P{EP}Cyt-c-d^G12271

Kyoto

101994

P{PZ}Cyt-c-d^bln1 cn¹ / CyO ; ry⁵⁰⁶

NIG-Fly

HMJ21900

y¹ v¹; P{TRiP.HMJ21900}attP40/CyO

2LG-0995

y² VhaAC39-1^cho-1 v¹; P{U6-Cyt-c-d.NIG.sgRNA}attP40/CyO

VDRC

v101079

P{KK106830}VIE-260B

v17128

w¹¹¹⁸; P{GD7970}v17128

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP05614

Other clones

DPiM_LP05614

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086907

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086907

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Cyt-c-d regulates developmental apoptosis in the eye.

(Mendes et al., 2006)

Cyt-c-d is neither necessary nor sufficient for caspase activation and apoptosis in Drosophila cells.

(Dorstyn et al., 2004)

Postmeiotic differentiation defect.

(Castrillon et al., 1993)

The Cyt-c-d protein could not be detected as a functional cytochrome molecule at any stage of development.

(Inoue et al., 1986)

Cyt-c-d encodes a functional cytochrome c protein. Cyt-c-d is expressed at constant low levels throughout development and the predicted polypeptide sequence differs from Cyt-c-p at 32 amino acid residues. Cyt-c-d and Cyt-c-p are located 3.5kb apart and have arisen from an ancient duplication event.

(Limbach and Wu, 1985)

A cDNA clone for the thoracic muscle cytochrome c gene from M.sexta has been used to isolate the corresponding major thoracic muscle cytochrome c gene from D.melanogaster. Hybridisation studies reveal that Cyt-c-d is expressed at almost undetectable levels in adult thoracic muscle tissue. Cyt-c-d shares limited nucleotide homology with Cyt-c-p.

(Swanson et al., 1985)

Apparently the structural gene for one of two cytochrome-c type enzymes, which differ from each other in 32/107 amino-acid residues. First isolated from a Charon-4 library using mouse cytochrome-c gene sequence as a probe. Cyt-c-d (sequence D3) expressed at constant, but relatively low, level throughout development; Cyt-c-p (sequence D4) expressed at varying, but relatively high, levels throughout development. Amino acid sequence also given in Fasman (1977).

Relationship to Other Genes

Source for database merge of

Source for merge of: Cyt-c-d bln

(Arama et al., 2006)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

CG13263

(Curcio et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Caggese et al., 2006)

CYC

(Caggese et al., 2006)

CYTC

(Mendez et al., 2016)

Cyt C

(Grant et al., 2010)

Cyt c

(de Castro et al., 2013, Wang et al., 2011, Abdelwahid et al., 2007, Challa et al., 2007)

Cyt-c1

CytC

(Zhang et al., 2013)

CytC-1

CytC1

(Groen et al., 2022, Maroni, 1994)

Cytc

(Shaik et al., 2012, Meier et al., 2000)

Cytc-d

(Dorstyn et al., 2004)

DC3

(Dorstyn et al., 2004, Varkey et al., 1999, Inoue et al., 1986, Limbach and Wu, 1985)

bln

(Peterson et al., 2007, Rathke et al., 2007, Nevers et al., 2006, Dorstyn et al., 2004, Huh et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999, Castrillon et al., 1993)

bs30f07.y1

(Andrews et al., 2000)

cyt c

(Jiang et al., 2020, von Stockum et al., 2011, Haghnia et al., 2007)

cyt c-d

(Kuranaga and Miura, 2007, Mendes et al., 2006)

cyt-c-d

(Duan et al., 2024, Napoletano et al., 2017, Yang et al., 2013, White-Cooper, 2012, Shieh and Bonini, 2011, Peterson et al., 2007, Arama et al., 2006, Arama et al., 2006, Mendes et al., 2006, Arama and Steller, 2005, Kornbluth and White, 2005, Arama and Steller, 2004, Huh et al., 2004, Baehrecke, 2003)

cyt.c

(Rodriguez et al., 1999)

cyt.c-d

(Kanda et al., 2011)

cytc-d

(Nazer et al., 2018, Mendez et al., 2016)

cytochrome c

(Walker and Benzer, 2004)

dc3

(Chan et al., 2007, Means et al., 2006, Wong et al., 2005, Dorstyn et al., 2004)

ms(2)04445

pDMc02

(Swanson et al., 1985)

Name Synonyms

Cytochrome C

(White, 1999)

Cytochrome c

(Li et al., 2021, Shaik et al., 2012, Shepherd and Dailey, 2009, Caggese et al., 2006, Tripoli et al., 2005, Danial and Korsmeyer, 2004)

Cytochrome c distal

(Wasbrough et al., 2010)

blanks

(Rathke et al., 2007, Nevers et al., 2006)

cytochrome C

(Means et al., 2006, Igaki and Miura, 2004)

cytochrome c distal

(Shieh and Bonini, 2011)

cytochrome c-d

(Kanda et al., 2011)

cytochrome-c-d

(Peterson et al., 2007)

Secondary FlyBase IDs

FBgn0000408
FBgn0011213

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34995

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P04657

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P04657

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PD22

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P04657

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086907

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34995/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086907

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086907

FlyMine - An integrated database for Drosophila genomics

FBgn0086907

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG13263

MARRVEL_MODEL - MARRVEL (model organism gene)

34995

Linkouts

BioGRID - A database of protein and genetic interactions.

61002

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086907

DroID - A comprehensive database of gene and protein interactions.

FBgn0086907

DRSC - Results frm RNAi screens

FBgn0086907

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086907

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13263

Flygut - An atlas of the Drosophila adult midgut

FBgn0086907

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005841

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

34995

MIST (protein-protein) - An integrated Molecular Interaction Database

34995

References (141)

The following external sites may use different assemblies or annotations than FlyBase.

4.85

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