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Citation
Nicola├», L.J., Ramaekers, A., Raemaekers, T., Drozdzecki, A., Mauss, A.S., Yan, J., Landgraf, M., Annaert, W., Hassan, B.A. (2010). Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 107(47): 20553--20558.
FlyBase ID
FBrf0212380
Publication Type
Research paper
Abstract

In recent years, Drosophila melanogaster has emerged as a powerful model for neuronal circuit development, pathology, and function. A major impediment to these studies has been the lack of a genetically encoded, specific, universal, and phenotypically neutral marker of the somatodendritic compartment. We have developed such a marker and show that it is effective and specific in all neuronal populations tested in the peripheral and central nervous system. The marker, which we name DenMark (Dendritic Marker), is a hybrid protein of the mouse protein ICAM5/Telencephalin and the red fluorescent protein mCherry. We show that DenMark is a powerful tool for revealing novel aspects of the neuroanatomy of developing dendrites, identifying previously unknown dendritic arbors, and elucidating neuronal connectivity.

PubMed ID
PubMed Central ID
PMC2996714 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Personal communication to FlyBase

P{UAS-DenMark} insertions.
Hassen, 2010.12.22, P{UAS-DenMark} insertions. [FBrf0212859]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference