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Citation
Zhang, C., Hong, Z., Ma, W., Ma, D., Qian, Y., Xie, W., Tie, F., Fang, M. (2013). Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage.  PLoS ONE 8(11): e78652.
FlyBase ID
FBrf0223434
Publication Type
Research paper
Abstract

UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter upon exposure to ionizing radiation (IR) in a p53-dependent manner. UTX interacts physically with p53, and both UTX and p53 are recruited to the ku80 promoter following IR exposure in an interdependent manner. In contrast, the loss of utx has little impact on the expression of ku70, mre11, hid and reaper, suggesting the specific regulation of ku80 expression by UTX. Thus, our findings further elucidate the molecular function of UTX.

PubMed ID
PubMed Central ID
PMC3827076 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Alleles (3)
    Genes (7)
    Physical Interactions (2)
    Cell Lines (1)
    Insertions (1)