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General Information
Symbol
Dmel\Utx1
Species
D. melanogaster
Name
FlyBase ID
FBal0264573
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dUTX1
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C10273390T

Amino acid change:

Q966term | Utx-PA; Q769term | Utx-PB; Q769term | Utx-PC; Q960term | Utx-PD; Q764term | Utx-PE

Reported amino acid change:

Q966term

Comment:

The position of the mutation was reported relative to isoform Utx-PA. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A premature termination codon in the JmjC domain.

Amino acid replacement: ?966term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Utx1 mutants are homozygous lethal.

The majority of Utx1/Df(2L)BSC143 animals that are derived from Utx1/+ females develop into adults that are morphologically indistinguishable from wild type, but die shortly after eclosion.

Homozygotes only rarely survive to adulthood.

Homozygous clones in the eye-antennal imaginal disc do not show an overproliferation phenotype.

The normal degradation of salivary glands is significantly delayed in Utx1 mutants - intact glands are still present in many animals at 24 h relative to puparium formation.

Utx1 homozygotes survive past the head eversion stage but die before eclosion.

Utx1 salivary glands show reduced caspase activity and reduced autophagy, compared to controls.

UtxΔ95/Utx1 animals can develop into adults, which show no detectable morphological defects.

UtxΔ95/Utx1 embryos show a markedly lower hatching rate compared to wild type. Treatment with 10 Gy of ionizing radiation reduces the hatching rate of UtxΔ95/Utx1 embryos to a greater extent than that of wild type. In contrast, the hatching rate of mutant embryos is not significantly different to wild type after UV radiation exposure.

The overall size of Utx1 mosaic eyes is normal; however, Utx1 mutant tissue represents a larger fraction of the eye. This overrepresentation phenotype is already apparent in mosaic eye-antennal imaginal discs.

While most homozygotes die during pupal stages, a small percentage (< 5%) develop as viable adults. Nevertheless, these homozygous escapers die immediately after eclosion.

The sex combs of Utx1/Utxf01321 males contain fewer teeth (6-8) than wild type (~10).

Homozygotes have rough eyes.

Utx1/Utxf01321 wings sometimes contain fluid-trapped blisters.

No significant change in apoptosis is observed for Utx1 mosaics during eye imaginal disc development.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Utx1 has eye | somatic clone phenotype, enhanceable by RbfΔ14/Rbf[+]

Suppressed by
Statement
Reference

Utx1 has eye | somatic clone phenotype, suppressible by E(z)[+]/E(z)731

Utx1 has eye | somatic clone phenotype, suppressible by Pc1/Pc[+]

Utx1 has eye | somatic clone phenotype, suppressible by N[+]/N264-39

Enhancer of
Statement
Reference

Utx[+]/Utx1 is an enhancer of eye phenotype of Scer\GAL4ey.200.Exel, TAF1BdsRNA.UAS

Utx[+]/Utx1 is an enhancer of eye phenotype of DlUAS.cDa, Scer\GAL4ey.PH, lolaGS88A8, psqGS88A8

Suppressor of
Statement
Reference

Utx[+]/Utx1 is a suppressor of wing margin phenotype of Ser1

Other
Additional Comments
Genetic Interactions
Statement
Reference

The frequency of eye tissue to antenna-like malformed structures transformation in adult flies expressing TAF1BdsRNA.Scer\UAS under the control of Scer\GAL4ey.200.Exel is increased by combination with a single copy of Utx1.

Scer\GAL4Sgs3.PD-mediated expression of EcRdsRNA.Scer\UAS.cCa in a Utx1 background significantly reduces the proportion of animals surviving to head eversion, compared to Utx1 animals alone.

Heterozygosity for E(z)731 or Pc1 or N264-39 suppresses the over-representation phenotype of Utx1 mosaics.

The wing notching phenotype of Ser1 or Df(1)N-8heterozygotes is dominantly suppressed by Utx1.

Scer\GAL4ey.PH-mediated expression of DlScer\UAS.cDa, psqGS88A8 and lolaGS88A8 causes mild overgrowth of the eye (the 'eyeful' phenotype) at 18[o]C. This phenotype is enhanced by heterozygosity for Utx1 : approximately 80% of flies show enlarged ventral halves of the eyes, while the remaining 20% have ventrally located outgrowths and ectopic eye tissue.

MARCM clones of DlScer\UAS.cUa in Utx1 mosaic eyes result in massive overgrowth of the adult eye and head. The overgrowth is so strong that only a few mosaic flies are recovered as adults; most die at pupal stages.

MARCM clones of Ras85DV12.S35.Scer\UAS in Utx1 mosaic eyes result in mild overgrowth of the adult eye.

Heterozygosity for RbfΔ14 strongly enhances the over-representation phenotype of Utx1 mosaic eyes: all mosaic eyes are now composed of almost 100% Utx1 tissue.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Scer\GAL4Sgs3.PD-mediated expression of UtxScer\UAS.cHa partially rescues the delayed salivary gland degradation of the Utx1 mutant.

Scer\GAL4Sgs3.PD-mediated expression of UtxScer\UAS.JmjC fails to rescue the delayed salivary gland degradation of the Utx1 mutant.

Expression of UtxScer\UAS.cHa reverts the over-representation phenotype seen in mosaic Utx1 eye-antennal discs.

Expression of UtxScer\UAS.JmjC fails to revert the over-representation phenotype seen in mosaic Utx1 eye-antennal discs.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)