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General Information
Symbol
Dmel\DlUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0152597
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dl, UAS-Delta, UAS-Dl30
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Dl.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of DlScer\UAS.cUa under the control of Scer\GAL4dpp.PU results in shrunken and completely deformed adult wings at 25[o]C but this phenotype is masked at 18[o]C and the wings appear normal.

Expression of DlScer\UAS.cUa under the control of Scer\GAL4ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) results in significantly decreased adult lifespan and loss of dopaminergic neurons from the PPL1, PPM1/2 and PPM3 clusters in the adult brain. Expression under the control of Scer\GAL4elav.PU in combination with Scer\GAL80ple.PK (and tub-Gal80[ts] to limit the time of expression to adulthood) does not significantly affect adult survival.

Expression of DlScer\UAS.cUa under the control of Scer\GAL4kirre.PU does not affect myoblast fusion in embryos.

Expression of DlScer\UAS.cUa under the control of either Scer\GAL4C855a or Scer\GAL4c768 results in an expansion of neuroepithelial cells in the outer proliferation center of late-third larval instar optic lobes. Fewer medulla neuroblasts than normal are seen in the mutant brains.

MARCM clones of DlScer\UAS.cUa result in mild overgrowth of the adult eye.

Flies expressing DlScer\UAS.cUa under the control of Scer\GAL4GMR.PF have a rough eye phenotype.

Expression of DlScer\UAS.cUa under the control of Scer\GAL4sv.PJ results in multiple rows of pigment cells surrounding each ommatidial cluster in the pupal eye disc (in contrast to wild type where each ommatidium is surrounded by a single hexagonal array of pigment cells).

Expression of DlScer\UAS.cUa under the control of Scer\GAL4kni.L2 results in modest truncation of wing vein L2 in females and almost complete absence of vein L2 in males.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference

DlUAS.cUa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has visible phenotype, non-suppressible by trbdDelta/trbd[+]

Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

DlUAS.cUa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, non-suppressible by trbdDelta/trbd[+]

Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Flies expressing DlScer\UAS.cUa under the control of Scer\GAL4dpp.PU and kept at 18[o]C do not display any overt wing phenotype but show notching of the wing margin upon co-expression of either Neurl4EY12221 or HERC2G17171.

The loss of dopaminergic neurons from the PPL1, PPM1/2 and PPM3 clusters in the adult brain characteristic for flies expressing DlScer\UAS.cUa under the control of Scer\GAL4ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) can be prevented by co-expression of any of the following: neurScer\UAS.cUa, LrrkGD11670, Neurl4GD11930 or HERC2VDRC.cUa.

MARCM clones of DlScer\UAS.cUa in Utx1 mosaic eyes result in massive overgrowth of the adult eye and head. The overgrowth is so strong that only a few mosaic flies are recovered as adults; most die at pupal stages.

Co-expression of RbfScer\UAS.cDa suppresses the strong overgrowth phenotype seen when DlScer\UAS.cUa is overexpressed in Utx1 mosaic eyes.

trbdDelta/+ does not suppress the rough eye phenotype caused by expression of DlScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference

Flies expressing DlScer\UAS.cUa under the control of Scer\GAL4dpp.PU and kept at 18[o]C do not display any overt wing phenotype but show notching phenotype upon co-expression of either Hsap\LRRK2Scer\UAS.cVa or Hsap\LRRK2RG.Scer\UAS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
DlScer\UAS.cUa
DlUAS.cUa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Unknown
Secondary FlyBase IDs
    References (19)