Zhang, J., Yin, J.C., Wesley, C.S. (2013). From Drosophila development to adult: clues to Notch function in long-term memory.  Front. Cell. Neurosci. 7(): 222.

FBrf0223532

Review

Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in memory loss upon neurodegeneration. Our studies in the model organism Drosophila reveal that a non-canonical Notch-protein kinase C activity that plays critical roles in embryonic development also regulates cyclic-AMP response element binding protein during LTM formation in adults. Here we present a perspective on how the various known features of Notch function relate to LTM formation and how they might interface with elements of Wingless/Wnt signaling in this process.

PMC3836050 (PMC) (EuropePMC)