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Zhang, J., Tanenhaus, A.K., Davis, J.C., Hanlon, B.M., Yin, J.C. (2015). Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.  Neurobiol. Learn. Mem. 118C(): 80--88.
FlyBase ID
FBrf0227547
Publication Type
Research paper
Abstract

CREB (cAMP response element-binding protein) is an evolutionarily conserved transcription factor, playing key roles in synaptic plasticity, intrinsic excitability and long-term memory (LTM) formation. The Drosophila homologue of mammalian CREB, dCREB2, is also important for LTM. However, the spatio-temporal nature of dCREB2 activity during memory consolidation is poorly understood. Using an in vivo reporter system, we examined dCREB2 activity continuously in specific brain regions during LTM processing. Two brain regions that have been shown to be important for Drosophila LTM are the ellipsoid body (EB) and the mushroom body (MB). We found that dCREB2 reporter activity is persistently elevated in EB R2/R4m neurons, but not neighboring R3/R4d neurons, following LTM-inducing training. In multiple subsets of MB neurons, dCREB2 reporter activity is suppressed immediately following LTM-specific training, and elevated during late windows. In addition, we observed heterogeneous responses across different subsets of neurons in MB αβ lobe during LTM processing. All of these changes suggest that dCREB2 functions in both the EB and MB for LTM formation, and that this activity contributes to the process of systems consolidation.

PubMed ID
PubMed Central ID
PMC4331215 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neurobiol. Learn. Mem.
    Title
    Neurobiology of Learning and Memory
    Publication Year
    1995-
    ISBN/ISSN
    1074-7427
    Data From Reference