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Gene Dmel\Orc6

General Information
Symbol	Dmel\Orc6	Species	D. melanogaster
Name	Origin recognition complex subunit 6	Annotation symbol	CG1584
Feature type	protein_coding_gene	FlyBase ID	FBgn0023180
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	ORC, DmORC6
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46B4-46B4	Sequence location	2R:5,732,964..5,733,964 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Origin recognition complex subunit 6 is referred to in FlyBase by the symbol Dmel\Orc6 (CG1584, FBgn0023180). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: positive regulation of GTPase activity; DNA-dependent DNA replication initiation; mitosis; DNA replication; M phase of mitotic cell cycle. 14 alleles are reported. The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; trichogen cell; imaginal disc; embryonic/larval brain; embryonic/larval optic lobe. It has one annotated transcript and one annotated polypeptide. Protein features are: Origin recognition complex, subunit 6; Origin recognition complex, subunit 6, metazoa/plant. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627090_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Orc6. Gene sequence location is 2R:5732964..5733964.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN28169 HFA07497
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46B4-46B4   Limits computationally determined from genome sequence between P{lacW}l(2)k05420k05420 and P{lacW}l(2)k07803k07803&P{lacW}l(2)k08816k08816
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46B6-46B8   (determined by in situ hybridisation)   (Chesnokov et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Orc6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Orc6-RA FBtr0088482  NM_057971   945   257
Additional Transcript Data & Comments
Reported size (kB)	1.2, 1.1 (northern blot) (Chesnokov et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Orc6-PA   FBpp0087566   29.2   257   9.13     NP_477319   AAF58890
Additional Polypeptide Data & Comments
Reported size (kDa)	257 (aa); 30 (kD observed) (Chesnokov et al., 1999)
Comments	Orc6 protein was isolated from purified ORC (origin recognition complex) from 0-12hr embryos. The six-subunit ORC can be reconstituted with recombinant proteins into a complex that restores DNA replication in ORC-depleted Drosophila or Xenopus extracts. (Chesnokov et al., 1999)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Origin recognition complex, subunit 6 (IPR008721) Origin recognition complex, subunit 6, metazoa/plant (IPR020529)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950133   AE013599 AAF58890   AC007413   AF139064 AAD39474   AW942901   AY071443 AAL49065   BI172654   BI216828   BI367066   CO276674   CO295161   CO340905   CZ480400   EC064159   EC220508
UniProtKB/Swiss-Prot	Q9Y1B2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Chesnokov et al., 1999) embryonic stage & larval stage     (Chesnokov et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023180    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023180 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023180 expression level Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  (1362) embryo 04-06hr  (2100) embryo 06-08hr  (1896) embryo 08-10hr  (1534) embryo 10-12hr  (870) embryo 12-14hr  (416) embryo 14-16hr  (376) embryo 16-18hr  (289) embryo 18-20hr  (156) embryo 20-22hr  (202) embryo 22-24hr  (235) larva L1  (295) larva L2  (363) larva L3 12hr old  (176) larva L3 puffstage 1-2  (364) larva L3 puffstage 3-6  (294) larva L3 puffstage 7-9  (340) white prepupae new  (310) white prepupae 12hr  (445) white prepupae 24hr  (234) pupae 2d postWPP  (146) pupae 3d postWPP    52 pupae 4d postWPP  (126) adult male 01day    83 adult male 05day    87 adult male 30day  (112) adult female 01day  (706) adult female 05day  (1822) adult female 30day  (1706) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr    1362 embryo 04-06hr  (2100) embryo 06-08hr  (1896) embryo 08-10hr  (1534) embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day  (1822) adult female 30day  (1706) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023180 expression level Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  (1362) embryo 04-06hr  (2100) embryo 06-08hr  (1896) embryo 08-10hr  (1534) embryo 10-12hr  (870) embryo 12-14hr  (416) embryo 14-16hr  (376) embryo 16-18hr  (289) embryo 18-20hr  (156) embryo 20-22hr  (202) embryo 22-24hr  (235) larva L1  (295) larva L2  (363) larva L3 12hr old  (176) larva L3 puffstage 1-2  (364) larva L3 puffstage 3-6  (294) larva L3 puffstage 7-9  (340) white prepupae new  (310) white prepupae 12hr  (445) white prepupae 24hr  (234) pupae 2d postWPP  (146) pupae 3d postWPP    52 pupae 4d postWPP  126 adult male 01day    83 adult male 05day    87 adult male 30day  112 adult female 01day  (706) adult female 05day  (1822) adult female 30day  (1706) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr    1362 embryo 04-06hr  2100 embryo 06-08hr  1896 embryo 08-10hr  1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day  1822 adult female 30day  1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    1362 embryo 04-06hr    2100 embryo 06-08hr    1896 embryo 08-10hr    1534 embryo 10-12hr    870 embryo 12-14hr    416 embryo 14-16hr    376 embryo 16-18hr    289 embryo 18-20hr    156 embryo 20-22hr    202 embryo 22-24hr    235 larva L1    295 larva L2    363 larva L3 12hr old    176 larva L3 puffstage 1-2    364 larva L3 puffstage 3-6    294 larva L3 puffstage 7-9    340 white prepupae new    310 white prepupae 12hr    445 white prepupae 24hr    234 pupae 2d postWPP    146 pupae 3d postWPP    52 pupae 4d postWPP    126 adult male 01day    83 adult male 05day    87 adult male 30day    112 adult female 01day    706 adult female 05day    1822 adult female 30day    1706 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023180    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023180 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023180 expression level Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023180 expression level Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    120.125 Larval Midgut no informative data Larval Hindgut    26.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    33.6 Larval Trachea    45.775 Larval Carcass    28.55 Adult Head no informative data Adult Eye    7.65 Adult Brain    25.6 Adult Thoracic-Abdominal Ganglion    30.4 Adult Crop no informative data Adult Midgut    26.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    274.8 Adult Testis    3.7 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    7.65   NA  Brain    25.6   120.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    30.4   NA  Crop    no informative data   no informative data  Midgut    26.3   26.2  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   33.6  Salivary Gland    no informative data   NA  Heart    no informative data   45.775  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    274.8   NA  Testis    3.7   NA  Male Accessory Gland    6   28.55  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023180 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1584-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Orc6 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Orc6GD4479 lethal | third instar larval stage Orc635 viable, with Scer\GAL4pnr-MD237 Orc6GD4479 Other Phenotypes Allele increased cell death Orc6163.T:Avic\GFP Orc6dsRNA.cCa mitotic cell cycle defective Orc635 mitotic cell cycle defective (with Orc635) Orc6W228A.K229A.T:Avic\GFP Orc6ΔC.220.T:Avic\GFP mitotic cell cycle defective (with Orc6W228A.K229A.T:Avic\GFP) Orc635 mitotic cell cycle defective (with Orc6ΔC.220.T:Avic\GFP) Orc635 neuroanatomy defective | embryonic stage Orc635 neuroanatomy defective | larval stage Orc635 visible, with Scer\GAL4pnr-MD237 Orc6GD4479 Phenotype manifest in Allele embryonic/larval brain (with Orc635) Orc6ΔC.220.T:Avic\GFP Orc6W228A.K229A.T:Avic\GFP embryonic/larval brain (with Orc6W228A.K229A.T:Avic\GFP) Orc635 embryonic/larval brain (with Orc6ΔC.220.T:Avic\GFP) Orc635 embryonic/larval brain | larval stage, with Scer\GAL41407 Orc6GD4479 embryonic/larval optic lobe Orc635 imaginal disc Orc635 presumptive embryonic salivary gland Orc635 trichogen cell, with Scer\GAL4pnr-MD237 Orc6GD4479
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Orc6 Class Mutagen Stocks Known lesion Orc635 Delta2-3 0 Yes Orc6e02618 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Orc6 Class Mutagen Stocks Known lesion Orc6GD4479 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Orc6KK108169 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Orc6+t3.3 in vitro construct - genomic fragment 0 Yes Orc6163.T:Avic\GFP in vitro construct 0 Yes Orc6200.T:Avic\GFP in vitro construct 0 Yes Orc6224.T:Avic\GFP in vitro construct 0 Yes Orc6dsRNA.cCa in vitro construct - RNAi 0 Yes Orc6MtnA.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Orc6T:Avic\GFP in vitro construct - coding region fusion 0 Yes Orc6W228A.K229A.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Orc6ΔC.200.T:Avic\GFP in vitro construct - deletion in vitro construct - coding region fusion 0 Yes Orc6ΔC.220.T:Avic\GFP in vitro construct - deletion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Orc635 (Balasov et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4479} NA P{KK108169} NA characterization construct P{CG1667-Orc6-genomic3.3} NA P{GFP-Orc6.1-200} NA P{GFP-Orc6.1-220} NA P{Orc6.WK228AA.GFP} NA P{UAS-GFP-Orc6} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Orc6e02618 NA insertion of mobile activating element P{EPgy2}EY04071 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA-dependent DNA replication initiation inferred from direct assay (Chesnokov et al., 1999) DNA replication inferred from direct assay (Balasov et al., 2009) mitosis inferred from mutant phenotype (Balasov et al., 2009) M phase of mitotic cell cycle inferred from mutant phenotype (Balasov et al., 2009) positive regulation of GTPase activity inferred from direct assay (Huijbregts et al., 2009)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex inferred from direct assay (Chesnokov et al., 1999) origin recognition complex inferred from direct assay (Balasov et al., 2009) colocalizes_with plasma membrane inferred from direct assay (Huijbregts et al., 2009) colocalizes_with septin complex inferred from direct assay (Huijbregts et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR008721 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
chromatin silencing non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) DNA-dependent DNA replication non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) DNA-dependent DNA replication initiation inferred from sequence or structural similarity with EMBL:AF139659 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex inferred from sequence or structural similarity with EMBL:AF139659 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Orc6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61846 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023180 DroID - A comprehensive database of gene and protein interactions. • FBgn0023180 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36017
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13143 Dere\GG25256 Dgri\GH21326 Dmoj\GI20744 Dper\GL10239 Dpse\GA24134 Dsec\GM24395 Dsim\GD10047 Dvir\GJ20481 Dwil\GK20964 Dyak\GE22006
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010253-PA Aedes aegypti (mosquito) AGAP011246-PA Anopheles gambiae (mosquito) At1g26840.1 Arabidopsis thaliana (wall cress) 228799 Branchiostoma floridae (lancelet) 237824 Branchiostoma floridae (lancelet) BGIBMGA004270-PA Bombyx mori (silk worm) ENSBTAP00000002438 Bos taurus (bovine) ENSCAFP00000005487 Canis familiaris (dog) CPIJ005016 Culex pipens (mosquito) ENSCPOP00000003412 Cavia porcellus (guinea pig) 210715 Capitella spl (polychaete worm) 304828 Daphnia pulex (daphnia) ENSDARP00000005160 Danio rerio (zebra fish) ENSECAP00000005244 Equus caballus (horse) ENSGALP00000006918 Gallus gallus (chicken) 125158 Hypsipyla robusta (cedar shoot borer) ENSP00000219097 Homo sapiens (human) ENSMODP00000030108 Monodelphis domestica (gray opossum) ENSMMUP00000015661 Macaca mulatta (rhesus monkey) ENSMUSP00000034132 Mus musculus (house mouse) ENSOANP00000005806 Ornithorynchus anatinus (platypus) LOC_Os07g43540.1 Oryza sativa (asian rice) PHUM009367-PA Pediculus humanus (human body louse) 134045 Physcomitrella patens (moss) ENSPPYP00000008716 Pongo pygmaeus (orangutan) 234484 Populus trichocarpa (black cottonwood) ENSPTRP00000013796 Pan troglodytes (chimpanzee) ENSRNOP00000035958 Rattus norvegicus (norway rat) 4749914 Sorghum bicolor (sorghum) XP_793313.1 Strongylocentrotus purpuratus (purple sea urchin) 60140 Trichoplax adhaerens (metazoa) XP_973201.1 Tribolium castaneum (red flour beetle) ENSXETP00000008444 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239239 FBgn0232496 FBgn0222956 FBgn0207621 FBgn0181822 FBgn0179258 FBgn0175456 JGI_V11_337598 JGI_V11_304828 FBgn0245533 FBgn0147849 FBgn0143479 FBgn0130739 FBgn0128788 FBgn0117378 FBgn0090176 CPIJ005016 BGIBMGA004270 AGAP011246 AAEL010253 PHUM411870 GLEAN_09250
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v101728 P{KK108169}VIE-260B v10677 w1118; P{GD4479}v10677/CyO
Genomic Clones ( 2 )
	BACR01L01 BACR30G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE52740
Other clones	DPiM_RE52740
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE15189 RE24110
Other clones	452 79046 EK121813 EK208761 EP11542
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023180 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36017
Antibody Information
	polyclonal (Chesnokov et al., 1999, Huijbregts et al., 2009, Balasov et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Orc6 mutants are defective in DNA replication and arrest in both G1 and mitosis. Orc6 mutants are unable to establish a true metaphase and fail to progress past this point. (Balasov et al., 2009)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057971 RefSeq (Proteins) • NP_477319 DDBJ / EMBL / GenBank • AA950133 AAD39474 AAF58890 AAL49065 AC007413 AF139064 AW942901 AY071443 BI367066 CZ480400 Entrez Gene - A searchable database of RefSeq genes. • 36017 UniProtKB/Swiss-Prot • Q9Y1B2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Origin recognition complex, subunit 6 (IPR008721) Origin recognition complex, subunit 6, metazoa/plant (IPR020529)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61846 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023180 DroID - A comprehensive database of gene and protein interactions. • FBgn0023180 DRSC - Results from RNAi screens. • FBgn0023180 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023180 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1584-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023180 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36017 InParanoid A subset of ortholog calls from InParanoid. • AAEL010253-PA Aedes aegypti (mosquito) AGAP011246-PA Anopheles gambiae (mosquito) At1g26840.1 Arabidopsis thaliana (wall cress) 228799 Branchiostoma floridae (lancelet) 237824 Branchiostoma floridae (lancelet) BGIBMGA004270-PA Bombyx mori (silk worm) ENSBTAP00000002438 Bos taurus (bovine) ENSCAFP00000005487 Canis familiaris (dog) CPIJ005016 Culex pipens (mosquito) ENSCPOP00000003412 Cavia porcellus (guinea pig) 210715 Capitella spl (polychaete worm) 304828 Daphnia pulex (daphnia) ENSDARP00000005160 Danio rerio (zebra fish) ENSECAP00000005244 Equus caballus (horse) ENSGALP00000006918 Gallus gallus (chicken) 125158 Hypsipyla robusta (cedar shoot borer) ENSP00000219097 Homo sapiens (human) ENSMODP00000030108 Monodelphis domestica (gray opossum) ENSMMUP00000015661 Macaca mulatta (rhesus monkey) ENSMUSP00000034132 Mus musculus (house mouse) ENSOANP00000005806 Ornithorynchus anatinus (platypus) LOC_Os07g43540.1 Oryza sativa (asian rice) PHUM009367-PA Pediculus humanus (human body louse) 134045 Physcomitrella patens (moss) ENSPPYP00000008716 Pongo pygmaeus (orangutan) 234484 Populus trichocarpa (black cottonwood) ENSPTRP00000013796 Pan troglodytes (chimpanzee) ENSRNOP00000035958 Rattus norvegicus (norway rat) 4749914 Sorghum bicolor (sorghum) XP_793313.1 Strongylocentrotus purpuratus (purple sea urchin) 60140 Trichoplax adhaerens (metazoa) XP_973201.1 Tribolium castaneum (red flour beetle) ENSXETP00000008444 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36017 modMine - Data generated by the modENCODE project. • FBgn0023180 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239239 FBgn0232496 FBgn0222956 FBgn0207621 FBgn0181822 FBgn0179258 FBgn0175456 JGI_V11_337598 JGI_V11_304828 FBgn0245533 FBgn0147849 FBgn0143479 FBgn0130739 FBgn0128788 FBgn0117378 FBgn0090176 CPIJ005016 BGIBMGA004270 AGAP011246 AAEL010253 PHUM411870 GLEAN_09250
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG1584 (Keleman et al., 2009.8.5) DmORC 6 (Shareef et al., 2001) DmORC6 (Chesnokov et al., 1999, Huang et al., 1998, Pak et al., 1997) ORC (Bielinsky et al., 2001, Wakimoto, 1998, Huang and Kellum, 1997) ORC6 (Chesnokov et al., 2002, Chesnokov, 1999.3.30, Wallrath, 1998, Kohzaki and Murakami, 2005, Badugu et al., 2005, Li et al., 2002, Shareef et al., 2003) Orc6 (Cayirlioglu et al., 2003, Balasov et al., 2007, Huijbregts et al., 2009, Ayroles et al., 2009, Balasov et al., 2009, Neumüller et al., 2011) orc6 (Balasov et al., 2009) rDmORC (Remus et al., 2004)
Name Synonym	Origin recognition complex subunit 6 (Pak et al., 1997, Cho et al., 2005)
Secondary FlyBase IDs
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 3 ) Review  ( 6 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...