Reference Report

Reference
Citation	Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D.M., Bettencourt-Dias, M. (2007). Revisiting the role of the mother centriole in centriole biogenesis. Science 316(5827): 1046--1050. (Export to RIS)
FlyBase ID	FBrf0201309
Publication Type	Research paper
PubMed ID	17463247
PubMed Abstract	Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formation in unfertilized eggs. Both processes required the activity of DSAS-6 and DSAS-4, two molecules required for canonical duplication. Thus, centriole biogenesis is a template-free self-assembly process triggered and regulated by molecules that ordinarily associate with the existing centriole. The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly.
DOI	10.1126/science.1142950
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (5)
	SAK^{Act5C.T:Hsap\MYC} SAK^{Scer\UAS.P\T.cRMa} Sas-4^{Ubi.T:Avic\GFP} sas-6^{Ubi.T:Avic\GFP} Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}
Constructs (4)
	P{matα4-GAL-VP16} P{UASp-SAK.RM} P{Ubi-GFP-sas-6} P{Ubi-Sas-4-GFP}
Genes (14)
	cnn Cp190 cp309 mus209 SAK Sas-4 sas-6 Scer\GAL4 T:Avic\GFP αTub67C αTub84B αTub84D γTub23C γTub37C
Natural transposons (1)
	P-element