FlyBase Allele Report: Dmel\hry[1]

General Information

Symbol

Dmel\hry¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005318

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

gypsy{}hry¹

Carried in Construct

Also Known As

h¹, hairy¹

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tearle and Nusslein-Volhard, 1987)

loss of function allele

(Long et al., 1996)

Mutagen

spontaneous

(Hooper et al., 1989, Ingham et al., 1985)

Progenitor genotype

Associated Insertion(s)

gypsy{}hry¹

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Description

Insert stated as cause: undefined Insertion upstream of the h promoter.

(Abu-Issa and Cavicchi, 1996)

Insertion of a 7kb gypsy element about 5kb upstream of the h promoter.

(Hooper et al., 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Zeng et al., 2000, Abu-Issa and Cavicchi, 1996, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

visible (with hry²⁶)

(Abed et al., 2011)

visible | recessive

(Rushlow et al., 1989)

visible | recessive | somatic clone

(Zeng et al., 2000)

Phenotype Manifest In

adult abdominal segment 4

(Ingham et al., 1985)

adult thorax & microchaeta | ectopic | somatic clone

(Zeng et al., 2000)

chemosensory ventral triple row bristle

(Dominguez and Campuzano, 1993)

dorsal row of triple row of wing sensilla

(Dominguez and Campuzano, 1993)

glial cell | ectopic

(Giangrande, 1995)

haltere & macrochaeta

(Ingham et al., 1985)

head capsule & macrochaeta

(Ingham et al., 1985)

larval abdominal segment 4

(Ingham et al., 1985)

macrochaeta | ectopic

(Rushlow et al., 1989, Ingham et al., 1985)

medial row of triple row of wing sensilla

(Dominguez and Campuzano, 1993)

mesothoracic tergum & macrochaeta | ectopic | conditional cs

(Gibert et al., 2005)

microchaeta & mesothoracic tergum | supernumerary

(Renaud and Simpson, 2002)

microchaeta | ectopic & scutellum

(Villa-Cuesta et al., 2003)

neuron

(Sturtevant and Bier, 1995)

neuron | ectopic

(Giangrande, 1995)

scutellum & macrochaeta

(Ingham et al., 1985)

wing

(Abu-Issa and Cavicchi, 1996, Giangrande, 1995)

wing & neuron & glial cell

(Giangrande, 1995)

wing cell (with hry²⁶)

(Abed et al., 2011)

wing hair

(Dominguez and Campuzano, 1993)

wing hair & wing vein L2

(Dominguez and Campuzano, 1993)

wing margin bristle

(Dominguez and Campuzano, 1993)

wing sensillum | ectopic

(Abu-Issa and Cavicchi, 1996)

wing sensillum | ectopic (with hry²⁶)

(Abed et al., 2011)

wing vein

(Giangrande, 1995)

wing vein & wing sensillum | ectopic | somatic clone

(Zeng et al., 2000)

wing vein | ectopic

(Giangrande, 1995)

wing vein L2 (with hry²⁶)

(Abed et al., 2011)

wing vein L2 & macrochaeta & adult

(Rushlow et al., 1989)

Detailed Description

Statement

Reference

Numerous ectopic bristles are present on h¹/h²⁶ wings, both in intervein regions (79% penetrance) and on the L2 wing vein (100% penetrance).

(Abed et al., 2011)

h¹ flies raised at 18^oC occasionally have ectopic bristles anterior to the anterior dorso-central bristle, while flies raised at 25^oC do not show this phenotype.

(Gibert et al., 2005)

h¹ animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.

(Renaud and Simpson, 2002)

Homozygous clones give rise to ectopic wing vein bristles and thoracic microchaetae.

(Zeng et al., 2000)

Flies have ectopic bristles on the wing surface.

(Abu-Issa and Cavicchi, 1996)

Ectopic glia accompany ectopic nerves in the pupal wing, which occur mostly along the longitudinal wing veins. Ectopic glial cells are present even on those ectopic veins that have reversed polarity.

(Giangrande, 1995)

Extra neuron mutant.

(Sturtevant and Bier, 1995)

Extra sense organs formed on wing surface. Campaniform sensillae preferentially form on the proximal end of the L3 vein, bristles form nearer the tip, and sense organs of intermediate size form in between the bristles and campaniform sensillae. Scanning electron microscope measurements of distribution of sense organs along the wing axis suggests that h is active in metamorphosis and has a pattern of expression that is dependent upon the position in the proximal-distal axis.

(Thompson and Preston, 1992)

Semilethal when heterozygous with strong h alleles.

(Hooper et al., 1989)

Homozygotes display ectopic bristles on the L2 wing vein.

(Rushlow et al., 1989)

70% of homozygotes survive to adulthood. Homozygous adults have extra bristles. Homozygotes have minor defects in segmentation, that are apparent both in the larva and the adult; a few segments are wholly or partially deleted. The fourth abdominal segment is most frequently affected, although other segments in the head, thorax or abdomen may also be affected. The frequency and severity of the segmentation phenotype is increased in trans with other lethal h alleles. h¹/h⁴¹ flies have ectopic bristles on the scutellum, halteres and head capsule.

(Ingham et al., 1985)

viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hry¹/hry²⁶ has visible phenotype, suppressible | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

Enhancer of

Statement

Reference

hry¹/h[+] is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Other

Statement

Reference

hry¹, nkd⁴ has visible | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd³ has visible | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd^unspecified has lethal phenotype

(Zeng et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

hry¹ has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by pad¹

(Gibert et al., 2005)

Suppressed by

Statement

Reference

hry¹/hry²⁶ has wing cell phenotype, suppressible by dgrn[+]/dgrn^DK

(Abed et al., 2011)

hry¹/hry²⁶ has wing sensillum | ectopic phenotype, suppressible | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

hry¹ has microchaeta | ectopic & scutellum phenotype, suppressible by amos^Tft

(Villa-Cuesta et al., 2003)

hry¹ has phenotype, suppressible by ac¹

(Sturtevant, 1970)

hry¹ has phenotype, suppressible by ac²

(Sturtevant, 1970)

hry¹ has phenotype, suppressible by ac³

(Sturtevant, 1970)

Enhancer of

Statement

Reference

hry¹/h[+] is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

hry¹/hry¹ is an enhancer of ventral denticle belt | embryonic stage | absent phenotype of nkd²

(Gammons et al., 2020)

hry¹ is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of pad¹

(Gibert et al., 2005)

Other

Statement

Reference

hry¹, nkd³/nkd² has ventral denticle belt | embryonic stage phenotype

(Gammons et al., 2020)

hry¹, nkd³ has ventral denticle belt | embryonic stage | absent phenotype

(Gammons et al., 2020)

hry¹, nkd³/nkd¹³ has ventral denticle belt | embryonic stage phenotype

(Gammons et al., 2020)

hry¹, nkd³ has ommatidium | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd⁴ has wing margin bristle | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd³ has eye | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd³ has wing margin bristle | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd⁴ has ommatidium | somatic clone phenotype

(Zeng et al., 2000)

hry¹, nkd⁴ has eye | somatic clone phenotype

(Zeng et al., 2000)

hry¹, rho^ve-1 has wing phenotype

(Biehs et al., 1998)

hry¹, rho^ve-1 has wing sensillum | ectopic phenotype

(Biehs et al., 1998)

Df(1)sc10-1, ac^T52.2, hry¹ has wing vein L5 phenotype

(van Doren et al., 1994)

Df(1)ase-1, hry¹ has wing hair & wing vein L2 phenotype

(Dominguez and Campuzano, 1993)

Additional Comments

Genetic Interactions

Statement

Reference

h¹ nkd³ double homozygous, h¹/h¹ nkd³/nkd¹³ double mutant or h¹/h¹ nkd²/nkd³ double mutant embryos exhibit defective denticle belts.

(Gammons et al., 2020)

dgrn^DK/+ suppresses the formation of ectopic wing bristles seen in h¹/h²⁶ flies, predominantly within the intervein regions.

(Abed et al., 2011)

pad¹ h¹ double mutants raised at 25^oC display ectopic bristles at positions on the notum where no ectopic bristles are found in either single mutant. These new positions include dorso-central bristles closer to the thoracic midline and additional bristles between the anterior and posterior scutellars. Ectopic bristles on the double mutant are mostly located in the posterior half of the notum, while ectopic bristles tend to be found in the anterior half in pad¹ single mutants.

(Gibert et al., 2005)

The ectopic microchaetae seen on the scutellum in h¹ flies are suppressed by amos^Tft.

(Villa-Cuesta et al., 2003)

h¹/h^- is viable, whereas nkd^unspecified h¹/h^- is lethal. nkd³ h¹ or nkd⁴ h¹ clones give rise to a rough eye phenotype and loss of wing margin bristles.

(Zeng et al., 2000)

h¹ rho^ve-1 / h¹ rho^ve-1 flies have ectopic bristles running between longitudinal veins.

(Biehs et al., 1998)

Introduction of ac^T52.2 construct into an ac^- sc^- h^- background causes ectopic bristles to appear along wing vein L5.

(van Doren et al., 1994)

Df(1)ase-1; h¹ double mutants have four-fold fewer bristles in the L2 vein than h¹ mutants alone. Although h¹ has no effect on the anterior wing margin bristles itself, the recurved bristles of Df(1)ase-1; h¹ double mutants are more wild type than those of Df(1)ase-1, though the mutant phenotype of the stout mechanosensory bristles is more extreme.

(Dominguez and Campuzano, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hry¹ is rescued by hry^hs.P1

(Rushlow et al., 1989)

Partially rescued by

hry¹ is partially rescued by hry^tRa

(Rushlow et al., 1989)

hry¹ is partially rescued by hry^cosh

(Rushlow et al., 1989)

Comments

When in combination with h^hs.P1 the ectopic bristle phenotype is completely suppressed. The temperature sensitive period for the bristle phenotype is 6-11 hours post-pupariation. Segmentation phenotype can be rescued by h^cosh and h^tRa, but the extra bristle phenotype cannot.

(Rushlow et al., 1989)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type