FlyBase Allele Report: Dmel\Rab6[08323]

General Information

Symbol

Dmel\Rab6⁰⁸³²³

Species

D. melanogaster

Name

FlyBase ID

FBal0008138

Feature type

allele

Associated gene

Dmel\Rab6

Associated Insertion(s)

P{PZ}Rab6⁰⁸³²³

Carried in Construct

Also Known As

l(2)08323

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Rab6⁰⁸³²³

Cytology

Description

P{PZ} insertion 30bp upstream of the start codon.

(Purcell and Artavanis-Tsakonas, 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:12,108,824..12,108,833 [-]

(Abrell et al., 2000, Purcell and Artavanis-Tsakonas, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of larval stage | recessive

(Purcell and Artavanis-Tsakonas, 1999)

some die during larval stage | recessive

(Purcell and Artavanis-Tsakonas, 1999)

visible | cell non-autonomous | recessive | somatic clone

(Purcell and Artavanis-Tsakonas, 1999)

Phenotype Manifest In

adult head & microchaeta | somatic clone | cell non-autonomous

(Purcell and Artavanis-Tsakonas, 1999)

adult thorax & microchaeta | somatic clone | cell non-autonomous

(Purcell and Artavanis-Tsakonas, 1999)

macrochaeta | cell non-autonomous | somatic clone

(Purcell and Artavanis-Tsakonas, 1999)

Detailed Description

Statement

Reference

Homozygous progeny from females containing homozygous germline clones develop past embryogenesis. Homozygous clones do not produce defects in eye, wing or leg development. Homozygous clones show defects in the macrochaetae, and the microchaetae on the head and thorax are also affected. The defects seen include defects in distal tip growth or prominent defects in the circumferential ridges normally produced by cytoplasmic protrusions between actin bundles. The phenotype is non-autonomous; portions of the homozygous clones contain mutant bristles while phenotypically wild-type bristles are also seen in the clones.

(Purcell and Artavanis-Tsakonas, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rab6⁰⁸³²³ is an enhancer of visible | dominant phenotype of Kr^If-1

(Abrell et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rab6⁰⁸³²³ is an enhancer of eye phenotype of Kr^If-1

(Abrell et al., 2000)

Rab6⁰⁸³²³ is an enhancer of ommatidium phenotype of Kr^If-1

(Abrell et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Rab6^D10A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D11A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D13E

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D14E

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D17E

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D1B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D23A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D27A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D28B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D2B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D2D

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D30D

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D31B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D35A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D3A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D40C

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D4A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D5A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D6B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D7C

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D9A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D9D

(Purcell and Artavanis-Tsakonas, 1999)

Fails to complement

Rab6^D12C

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D15A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D17B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D1A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D22A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D23D

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D24A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D28E

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D29D

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D37A

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D39B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D40B

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D5C

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D6E

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^D9C

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^eAM4

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^eAS1

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^eER1

(Purcell and Artavanis-Tsakonas, 1999)

Rab6^k13606

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12352

cn¹ P{PZ}Rab6⁰⁸³²³/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: bun⁰⁰²⁵⁵. Complements: Aats-thr^k04203. Complements: aret⁰¹²⁸⁴.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

P2352

(Purcell and Artavanis-Tsakonas, 1999)

Rab6⁰⁸³²³

l(2)08232

(Purcell and Artavanis-Tsakonas, 1999)

l(2)08323

(Abrell et al., 2000, Purcell and Artavanis-Tsakonas, 1999, Spradling et al., 1999)

l(2)08323⁰⁸³²³

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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