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General Information
Symbol
Dmel\grhs2140
Species
D. melanogaster
Name
FlyBase ID
FBal0009305
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the first intron of grh.

Insertion components
P{lacW}grhs2140
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the retina have symmetric ommatidia. In mosaic ommatidia adopting the wrong chiral form, the cell in the R4 position is always mutant, whereas the cell in the R3 position is equally likely to be mutant or wild type.

Early stage 16 grhs2140/Df(2R)Pcl7B embryos have more convoluted and elongated dorsal trunks (DTs) than wild-type embryos. This phenotype subsequently becomes more exaggerated, and by the end of stage 16 is also seen in additional branches of the tracheal system, including the lateral trunk, transverse connectives and ganglionic branches. Terminal branching is normal in these embryos, but at the end of embryogenesis the terminal branches become convoluted and often make loops.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

grhs2140/grh[+] is an enhancer of visible phenotype of DgdsRNA.UAS, Scer\GAL4Tub.PU

Suppressor of
Statement
Reference

grhs2140/grh[+] is a suppressor of visible phenotype of DysdsRNA.C.UAS, Scer\GAL4Tub.PU

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

One copy of grhs2140 strongly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU but produces extra wing vein material.

One copy of grhs2140 strongly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU but produces extra wing vein material.

One copy of grhs2140 in a DysE6/+ background results in posterior crossvein defects.

One copy of grhs2140 enhances the posterior crossvein phenotype seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

The bnl00857/+ tracheal branch outgrowth defects are partially suppressed by grhs2140/grhs2140; 78% of the tracheal ganglionic branches reach the central nervous system in the double mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

M. Scott.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)