brrbp-1/brnpr-6 and produce very few offspring. brrbp-2/brnpr-6 females live for two days before dying having laid no eggs. Their ovaries are not completely developed, and the few late stage oocytes that were formed had no appendages. The br2Bc-2/brnpr-6 heteroallelic combination is lethal. The offspring die as pupae. The br5/brnpr-6 heteroallelic combination is third larval instar lethal. The br6/brnpr-6 heteroallelic combination produces no females. The br1/brnpr-6 mothers produce eggs that have reduced dorsal appendages.
Female progeny brnpr-6/br1 survive until adulthood and produce eggs with reduced dorsal appendages.
Homozygotes die as late third instar larvae.
Lethality acts in the late third instar.
Df(1)P154/brnpr-6 larvae survive 2-3 days longer than brnpr-6 homozygotes. The early ecdysone puff at region 2B3-2B5 is active and does not regress until larval death.
Late third instar larvae die at puff stage 1.
Males lacking the puff at 2B5 (Df(1)S39/Dp(1;Y)Sz280) or brnpr-6 homozygotes are very similar in development. Growth and development of larvae is delayed, body size is small and larvae live two or three days longer than wild type but die as larvae. Homozygous and hemizygous larvae die without exhibiting any sign of ecdysone-inducible puff formation; culture of salivary glands in 20-OH ecdysone produces partial development of some early, but none of late ecdysone-inducible puffs and extraneous puff appears at 75CD.
brrbp-2/brnpr-6 and brrbp-5/brnpr-6 combination is lethal, rare adult escapers show a reduction of the bristle number on the palpus. Heterozygotes with Df(1)br25 have reduced viability and br wings.