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General Information
Symbol
Dmel\brnpr-6
Species
D. melanogaster
Name
FlyBase ID
FBal0013160
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
npr6, l(1)t435, npr16, l(1)t435, ecslt435
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

brrbp-1/brnpr-6 and produce very few offspring. brrbp-2/brnpr-6 females live for two days before dying having laid no eggs. Their ovaries are not completely developed, and the few late stage oocytes that were formed had no appendages. The br2Bc-2/brnpr-6 heteroallelic combination is lethal. The offspring die as pupae. The br5/brnpr-6 heteroallelic combination is third larval instar lethal. The br6/brnpr-6 heteroallelic combination produces no females. The br1/brnpr-6 mothers produce eggs that have reduced dorsal appendages.

Female progeny brnpr-6/br1 survive until adulthood and produce eggs with reduced dorsal appendages.

Homozygotes die as late third instar larvae.

Lethality acts in the late third instar.

Surviving brnpr-6/T(1;2)dorvar7 females may have wing abnormalities.

Df(1)P154/brnpr-6 larvae survive 2-3 days longer than brnpr-6 homozygotes. The early ecdysone puff at region 2B3-2B5 is active and does not regress until larval death.

Late third instar larvae die at puff stage 1.

Males lacking the puff at 2B5 (Df(1)S39/Dp(1;Y)Sz280) or brnpr-6 homozygotes are very similar in development. Growth and development of larvae is delayed, body size is small and larvae live two or three days longer than wild type but die as larvae. Homozygous and hemizygous larvae die without exhibiting any sign of ecdysone-inducible puff formation; culture of salivary glands in 20-OH ecdysone produces partial development of some early, but none of late ecdysone-inducible puffs and extraneous puff appears at 75CD.

brrbp-2/brnpr-6 and brrbp-5/brnpr-6 combination is lethal, rare adult escapers show a reduction of the bristle number on the palpus. Heterozygotes with Df(1)br25 have reduced viability and br wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

br1/brnpr-6 flies show reduced viability. The br5/brnpr-6 heteroallelic combination is lethal; The lethal period is during the 3rd instar larva. br6/+ x brnpr-6/+ crosses lead to transheterozygous males but no females being produced. Offspring die as pupae. brrbp-1/+ x brnpr-6/+ crosses lead to very few transheterozygous males but no females being produced. Offspring die as pupae. brrbp-2/brnpr-6 show reduced viability. The br2Bc-2/brnpr-6 heteroallelic combination is lethal. The offspring die as pupae. The br2Bc-1/brnpr-6 heteroallelic combination is lethal. The offspring die as 2nd to 3rd instar larvae.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

No 20-OH ecdysone puffs are seen in third instar larvae.

Sgs3 RNA and Gebf-I protein are absent in brnpr-6 mutant larvae.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (33)