FlyBase Allele Report: Dmel\Scr[14]

General Information

Symbol

Dmel\Scr¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0015290

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Sivanantharajah and Percival-Smith, 2009)

hypomorphic allele - genetic evidence

(Pattatucci et al., 1991)

Mutagen

ethyl methanesulfonate

(Pattatucci et al., 1991)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)

Description

Amino acid replacement: S10L.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: C10T.

(Sivanantharajah and Percival-Smith, 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,842,152..6,842,152 [-]

Nucleotide change:

C6842152T

Reported nucleotide change:

C10T

Amino acid change:

Reported amino acid change:

S10L

Comment:

Presumed typographic error in reported nucleotide position (C10T) should be C29T. Positions were reported with respect to the A of the ATG start codon.

(Sivanantharajah and Percival-Smith, 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die

(Pattatucci et al., 1991)

viable (with Df(3R)WIN3)

(Sivanantharajah and Percival-Smith, 2009)

visible | dominant

(Sivanantharajah and Percival-Smith, 2009)

Phenotype Manifest In

labial segment

(Pattatucci et al., 1991)

pronotum

(Pattatucci et al., 1991)

prothoracic segment

(Pattatucci et al., 1991)

pseudotrachea (with Scr²)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr⁴)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr¹¹)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr¹³)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr^13A)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr¹⁶)

(Sivanantharajah and Percival-Smith, 2009)

pseudotrachea (with Scr¹⁷)

(Sivanantharajah and Percival-Smith, 2009)

sex comb

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr²)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr³)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr⁴)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr⁵)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr⁸)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹¹)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹³)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr^13A)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹⁵)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹⁶)

(Sivanantharajah and Percival-Smith, 2009)

sex comb (with Scr¹⁷)

(Sivanantharajah and Percival-Smith, 2009)

Detailed Description

Statement

Reference

Scr¹⁴/Scr^13A flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls.

The number of nuclei in the salivary glands of Scr¹⁴/Df(3R)WIN3 larvae is not significantly different from normal.

Heterozygous males have a reduction in the number of sex comb bristles on the prothoracic leg compared to wild-type males.

(Sivanantharajah and Percival-Smith, 2009)

Prothoracic to mesothoracic, pronotal to mesonotal and labial to maxillary transformations. Polyphasic semi-lethality.

(Pattatucci et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Matthews.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scr¹⁴

(Sivanantharajah and Percival-Smith, 2009)

Scr^km7

(Pattatucci et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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