FlyBase Allele Report: Dmel\Dsor1[Su1]

General Information

Symbol

Dmel\Dsor1^Su1

Species

D. melanogaster

Name

FlyBase ID

FBal0039033

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Inoue and Glover, 1998, Sawamoto et al., 1996)

hypomorphic allele - genetic evidence

(Kurada and White, 1998)

Mutagen

ethyl methanesulfonate

(Tsuda et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: G192S.

(Lim et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:9,249,014..9,249,014 [+]

Nucleotide change:

G9249014A

Amino acid change:

G195S | Dsor1-PA; G192S | Dsor1-PB

Reported amino acid change:

G192S

Comment:

Reported as G192S in FBrf93573. Maps to G195S in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron. The annotated version is supported by full length cDNA LD41207 (GB:AY058692). The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

(Lim et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye

(Kurada and White, 1998)

ommatidium

(Lim et al., 1997)

photoreceptor cell R7

(Lim et al., 1997, Sawamoto et al., 1996)

pigment cell

(Kurada and White, 1998)

Detailed Description

Statement

Reference

Single mutant shows no mitotic figure mutant phenotype in larval brain neuroblast preparations.

(Inoue and Glover, 1998)

Shows supernumerary pigment cells in the developing eye, due to failure of apoptosis.

(Kurada and White, 1998)

The number of R7-like cells per ommatidium is slightly increased in homozygotes compared to wild-type flies.

(Lim et al., 1997)

2% of homozygous ommatidia exhibit supernumerary R7 cells.

(Sawamoto et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dsor1^Su1, Sos^JC2 has visible phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

NOT Enhancer of

Statement

Reference

Dsor1^Su1 is a non-enhancer of visible phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

Suppressor of

Statement

Reference

Dsor1^Su1 is a suppressor of visible phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of visible | dominant phenotype of N^55e11

(Nagaraj et al., 1999)

Dsor1^Su1 is a suppressor of lethal | germline clone phenotype of csw^Esev1A-eOP

(Tsuda et al., 1993)

Dsor1^Su1 is a suppressor of decreased occurrence of cell division | somatic clone | embryonic stage phenotype of Raf^raf-1

(Tsuda et al., 1993)

NOT Suppressor of

Statement

Reference

Dsor1^Su1 is a non-suppressor of visible phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

Other

Statement

Reference

Dsor1^Su1, Sos^JC2 has visible phenotype

(Taguchi et al., 2000)

Dsor1^Su1, tor^11D has some die during embryonic stage | dominant | maternal effect | maternal effect phenotype

(Lim et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dsor1^Su1, Sos^JC2 has wing vein | ectopic phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Dsor1^Su1, Sos^JC2 has wing phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, enhanceable by rl[+]/rl⁹

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype, enhanceable by rl[+]/rl⁹

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, enhanceable by rl[+]/rl^10a

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype, enhanceable by rl[+]/rl^10a

(Lim et al., 1999)

Suppressor of

Statement

Reference

Dsor1^Su1 is a suppressor of wing phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of crossvein phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of ommatidium phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of microchaeta phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of macrochaeta phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

Dsor1^Su1 is a suppressor of embryo | posterior phenotype of fs(1)M3¹⁹⁰¹

(Lim et al., 1999)

Dsor1^Su1 is a suppressor of wing margin phenotype of N^55e11

(Nagaraj et al., 1999)

Dsor1^Su1 is a suppressor of eye phenotype of asp¹

(Inoue and Glover, 1998)

Dsor1^Su1 is a suppressor of wing phenotype of asp¹

(Inoue and Glover, 1998)

Dsor1^Su1 is a suppressor of eye phenotype of asp^DD3

(Inoue and Glover, 1998)

Dsor1^Su1 is a suppressor of wing phenotype of asp^DD3

(Inoue and Glover, 1998)

Dsor1^Su1 is a suppressor of eye phenotype of hid^GMR.PG

(Kurada and White, 1998, Sawamoto et al., 1998)

Dsor1^Su1 is a suppressor of eye phenotype of rpr^GMR.PW

(Kurada and White, 1998)

Dsor1^Su1 is a suppressor of eye disc phenotype of hid^GMR.PG

(Sawamoto et al., 1998)

Dsor1^Su1 is a suppressor of phenotype of Raf¹

(Lim et al., 1997, Tsuda et al., 1993)

Dsor1^Su1 is a suppressor of phenotype of sev⁶

(Lim et al., 1997)

Dsor1^Su1 is a suppressor of phenotype of tor⁴

(Lim et al., 1997)

Dsor1^Su1 is a suppressor of embryonic/first instar larval cuticle phenotype of Egfr^f7

(Lim et al., 1997)

Dsor1^Su1 is a suppressor of head phenotype of Egfr^f7

(Lim et al., 1997)

Dsor1^Su1 is a suppressor of phenotype of aos^hs.PSa

(Sawamoto et al., 1996)

Other

Statement

Reference

Dsor1^Su1, Sos^JC2 has wing phenotype

(Taguchi et al., 2000)

Dsor1^Su1, Sos^JC2 has wing vein | ectopic phenotype

(Taguchi et al., 2000)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype

(Lim et al., 1999)

Dsor1^Su1, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su1, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Dsor1^Su1/Y ; Sos^JC2/+ flies have extra wing veins. This phenotype is enhanced by one copy of cln^SF3-2.

(Taguchi et al., 2000)

Strongly suppresses the lace^k05305/lace² phenotype.

(Adachi-Yamada et al., 1999)

Embryos derived from homozygous fs(1)M3¹⁹⁰¹ females fail to develop structures posterior to the seventh abdominal segment as well as anterior-most structures, including the head skeleton. The posterior defect is significantly suppressed if the female is also carrying one copy of Dsor1^Su1; an eighth abdominal segment is formed. This suppression is significantly reduced if the females are also carrying one copy of rl⁹, rl^10a or Df(2R)rl10b. Enhances the tor^11D phenotype; considerable numbers of embryos laid by females heterozygous for Dsor1^Su1 and tor^11D fail to hatch at 28^oC.

(Lim et al., 1999)

Suppresses the wing margin defect of N^55e11/+ flies.

(Nagaraj et al., 1999)

Suppresses the morphological defects and sterility of asp¹/asp^DD3 mutants. Survival of embryos is increased, fewer have no nuclei. The asp¹; Dsor1^Su1 double mutant shows reduction in the frequency of aneuploid and polyploid figures compared to asp¹ single mutants.

(Inoue and Glover, 1998)

Suppresses the eye reduction phenotype caused by rpr^GMR.PW. Suppresses the eye reduction phenotype caused by W^GMR.PG.

(Kurada and White, 1998)

Suppresses the reduced-eye and increased cell death phenotypes of W^GMR.PG.

(Sawamoto et al., 1998)

Completely suppresses the eye phenotype of phl¹ hemizygotes. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su1 have 2.62 +/- 0.83 R7-like cells per ommatidium. Partly suppresses the sev⁶ phenotype; flies hemizygous for sev⁶ and Dsor1^Su1 have an R7 photoreceptor cell in 28.7% of ommatidia. Partly suppresses the maternal tor⁴ phenotype; 80.3% of embryos derived from tor⁴ Dsor1^Su1 females have an A8 segment. Does not significantly alter the Egfr^E3 eye phenotype. Partly suppresses the Egfr^f7 phenotype.

(Lim et al., 1997)

Dsor1^Su1; argos¹⁵² flies exhibit extra R7-like cells in 25% of ommatidia. Suppression of P{hs-argos.S} rough eye phenotype is dose-dependent.

(Sawamoto et al., 1996)

Suppression of eclosion defects and rough eye phenotype of phl¹, increase the proliferation rate of phl^raf-1 and rescue defects associated with other phl mutations (alleles unspecified).

(Tsuda et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: phl¹.

(Tsuda et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dsor1^Su1

Dsor^Su1

(Kurada and White, 1998)

Name Synonyms

Secondary FlyBase IDs

References (16)

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