FlyBase Allele Report: Dmel\Dark[k11502]

Ark^k11502/Df(2R)BSC49 and Ark^k11502/Ark^P803-Δ15 third instar larvae show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.

Homozygous third instar larvae develop multiple black spots along the gut and sometimes in the salivary glands.

(Minakhina and Steward, 2006)

48% of Ark^k11502 mutant flies exhibit extra macrochaetae on the scutellum. Ark^k11502 mutants have one extra SOP cell in the scutellum region of the third instar wing disc. Analysis of the scutellum region of the pupal notum (24-30 h after pupal formation (APF)) shows that there is an extra neuron and thecogen present, which are derived from the extra SOP cell.

(Kanuka et al., 2005)

Unlike wild-type embyros UV irradition of Ark^k11502 homozygous pre-gastrula embryos at 50 mJ/cm² does not induce cell death.

(Zhou and Steller, 2003)

Mutants show only slight cell death defects in the embryo and barely detectable defects in adults.

(Rodriguez et al., 2002)

The outer morphology of homozygous larvae and flies appears normal, except for adult dorsal bristles; extra bristles are often seen on the scutellum. Abnormal ommatidia with one extra photoreceptor cell are often seen. The morphology of the pigment cell layer is disorganised compared to the regular pattern seen in wild-type flies. A significant decrease in apoptotic cells is seen in stage 11-12 homozygous embryos compared to wild type. The brain hemispheres of third instar larvae are larger than normal and contain a markedly decreased number of apoptotic cells.

(Kanuka et al., 1999)

Homozygous stage 12/1 embryos contain fewer apoptotic cells in the head region that wild-type embryos. The phenotype is highly penetrant but some variation is seen. Embryos often show defects in head involution and the brain appears larger than normal. Suppresses the eye phenotype caused by Dcp-1^GMR.PS or Dcp-1^N.GMR. A strong synergism in cell ablation is seen when Dcp-1^GMR.PS and rpr^GMR.PW are coexpressed in the eye. This phenotype is not modified by Ark^k11502.

(Zhou et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dark^k11502 is a suppressor of visible phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Dark^k11502 is a suppressor of visible phenotype of rpr^GMR.PW

(Kanuka et al., 1999)

NOT Suppressor of

Statement

Reference

Dark^k11502 is a non-suppressor of visible phenotype of hid^GMR.PG

(Kanuka et al., 1999)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dark^k11502 is a suppressor of eye phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Dark^k11502 is a suppressor of eye phenotype of rpr^GMR.PW

(Kanuka et al., 1999)

Dark^k11502 is a suppressor of eye phenotype of Dcp-1^GMR.PS

(Zhou et al., 1999)

Dark^k11502 is a suppressor of eye phenotype of Dcp-1^N.GMR

(Zhou et al., 1999)

NOT Suppressor of

Statement

Reference

Dark^k11502 is a non-suppressor of eye phenotype of hid^GMR.PG

(Kanuka et al., 1999, Zhou et al., 1999)

Dark^k11502 is a non-suppressor of eye phenotype of grim^GMR.PC

(Zhou et al., 1999)

Dark^k11502 is a non-suppressor of eye phenotype of rpr^GMR.PW

(Zhou et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The hatch rate of homozygous Ark^k11502 embryos is not reduced if the embryos are injected with th dsRNA (produced by annealing th^cIa and th^a.cIa RNA).

(Igaki et al., 2002)

The eye phenotype caused by expression of rpr^GMR.PW is significantly suppressed by Ark^k11502. The eye phenotype caused by expression of W^GMR.PG is not affected by Ark^k11502.

(Kanuka et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

11041

y¹ w^67c23; P{lacW}Dark^k11502/CyO

23285

y¹ w^*; P{lacW}Dark^k11502 Dark⁸²/CyO, y⁺

Kyoto

111308

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Dark^k11502 /CyO y⁺

Notes on Origin

Discoverer

Separable from: l(2)k11502^k11502.

(Kanuka et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Ark^k11502

(Waldron et al., 2015, Minakhina et al., 2007, Minakhina and Steward, 2006)

Dark^k11502

(Ciesielski et al., 2022)

P1041

(Rodriguez et al., 2002)

dArk^k11502

(Moskalev, 2003)

dapaf1^K1

dark^K11502

(Wang and Baker, 2015)

dark^P1041

(Kanuka et al., 2005, Rodriguez et al., 2002)

dark^k1

(Obata et al., 2014)

dpf^K1

(Ciesielski et al., 2022, Igaki et al., 2002, Kanuka et al., 1999)

hac-1^ac49

(Zhou and Steller, 2003)

l(2)k11502

(Zhou and Steller, 2003, Rodriguez et al., 2002, Quinn et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (17)

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