FlyBase Allele Report: Hsap\SNCA[A53T.UAS]

General Information

Symbol

Hsap\SNCA^A53T.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0104767

Feature type

allele

Associated gene

Hsap\SNCA

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\SNCA.A53T}

Also Known As

UAS-A53T, UAS-αSyn^A53T, UAS-SNCA^A53T, UAS-A53T α-synuclein, UAS-αSynA53T, SNCA.A53T, UAS-h[A53T]αSyn, UAS-α-syn-A53T

Key Links

Transgenic product class

missense_variant

(Feany and Bender, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Feany and Bender, 2000)

Mutagen

in vitro construct

(Feany and Bender, 2000)

Progenitor genotype

Carried in construct

P{UAS-Hsap\SNCA.A53T}

Cytology

Description

UASt regulatory sequences drive expression of the mutated A53T form of Hsap\SNCA (which is linked to a familial Parkinson's disease in humans).

(Feany and Bender, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\SNCA

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Lewy body dementia

CEA

(Imomnazarov et al., 2024)

model of Parkinson's disease

CEA

(Dinter et al., 2016, Zhu et al., 2016, Jahromi et al., 2015, Jahromi et al., 2015, Varga et al., 2014, Hernández-Vargas et al., 2011, Botella et al., 2008, Cooper et al., 2006, Yang et al., 2003, Feany and Bender, 2000)

model of synucleinopathy

CEA

(Alexopoulou et al., 2016)

model of Parkinson's disease 1

CEA

(Xia et al., 2025, Dhanushkodi et al., 2023, Diaw et al., 2023, Ledahawsky et al., 2022, Girard et al., 2021, Agerschou et al., 2019, Yan et al., 2019, Abul Khair et al., 2018, Saridaki et al., 2018)

CEC

(Nitta et al., 2023, Szinyákovics et al., 2023, Golomidov et al., 2022, Cunningham et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of synucleinopathy

is ameliorated by Usp8^HMS01898

(Alexopoulou et al., 2016)

model of Parkinson's disease 1

is ameliorated by Sfxn1-3^EY01545

(Ledahawsky et al., 2022)

is exacerbated by anne^KK107621

(Dhanushkodi et al., 2023)

is ameliorated by Hsap\FYCO1^UAS.cSa

(Saridaki et al., 2018)

is ameliorated by st^UAS.Venus

(Cunningham et al., 2018)

is ameliorated by Zzzz\β-wrapin^UAS.AS69

(Agerschou et al., 2019)

is ameliorated by Arl8^Q75L.UAS

(Szinyákovics et al., 2023)

is ameliorated by Rab2^{Q65L.UASp.YFP}

(Szinyákovics et al., 2023)

is exacerbated by Gba1b^GD10253

(Abul Khair et al., 2018)

model of Parkinson's disease

is ameliorated by Mmus\Rab1a^UAS.cCa

(Cooper et al., 2006)

is ameliorated by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

is ameliorated by Rab7^UAS.GFP

(Dinter et al., 2016)

ameliorates Parkinson's disease

modeled by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

exacerbates Kufor-Rakeb syndrome

modeled by anne^KK107621

(Dhanushkodi et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 2 )

FlyBase curator comment: "Parkinson's disease 1" is associated with mutations in human SNCA.

(Cunningham et al., 2018)

The locomotor defects seen in larvae expressing Hsap\SNCA[A53T.Scer\UAS] in dopaminergic neurons are exacerbated by rotenone.

(Varga et al., 2014)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Feany and Bender, 2000)

SNCA:p.Ala53Thr

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

External database links

ClinVar: SNCA_14007

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

(Feany and Bender, 2000)

abnormal locomotor behavior, with Scer\GAL4^ple.PF

(Varga et al., 2014)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Jahromi et al., 2015)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Ddc.HL9

(Alexopoulou et al., 2016)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PLu

(Agerschou et al., 2019, Saridaki et al., 2018, Dinter et al., 2016)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Shaltiel-Karyo et al., 2012)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^ple.PF

(Cunningham et al., 2018)

abnormal locomotor rhythm | adult stage, with Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

abnormal locomotor rhythm | adult stage, with Scer\GAL4^elav-C155

(Jahromi et al., 2015)

abnormal neuroanatomy, with Scer\GAL4^Ddc.PL

(Yang et al., 2003, Auluck et al., 2002)

abnormal neuroanatomy, with Scer\GAL4^ple.PF

(Varga et al., 2014, Cooper et al., 2006)

abnormal neuroanatomy | adult stage

(Alexopoulou et al., 2016)

abnormal neuroanatomy | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

abnormal neuroanatomy | progressive, with Scer\GAL4^ple.PF

(Botella et al., 2008)

chemical sensitive, with Scer\GAL4^elav-C155

(Jahromi et al., 2015)

decreased cell number | adult stage, with Scer\GAL4^ple.PF

(Cunningham et al., 2018)

decreased cell number | adult stage | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

decreased cell number | nutrition conditional, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

decreased rate of flight behavior, with Scer\GAL4^da.PU

(Diaw et al., 2023)

short lived, with Scer\GAL4^da.PU

(Diaw et al., 2023)

short lived, with Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

short lived, with Scer\GAL4^elav-C155

(Jahromi et al., 2015)

short lived | nutrition conditional, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

visible | adult stage, with Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Phenotype Manifest In

dopamine neuron & adult brain, with Scer\GAL4^elav.PLu

(Feany and Bender, 2000)

dopaminergic neuron, with Scer\GAL4^Ddc.PL

(Yang et al., 2003, Auluck et al., 2002)

dopaminergic neuron, with Scer\GAL4^ple.PF

(Cooper et al., 2006)

dopaminergic neuron | progressive, with Scer\GAL4^ple.PF

(Botella et al., 2008)

dopaminergic PPL1 neuron, with Scer\GAL4^ple.PF

(Cunningham et al., 2018)

dopaminergic PPM1 neuron | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

dopaminergic PPM2 neuron | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

dorso-lateral dopaminergic neuron, with Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

eye | adult stage, with Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

eye photoreceptor cell | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

larval dopaminergic DL1 neuron, with Scer\GAL4^ple.PF

(Varga et al., 2014)

larval dopaminergic DL2 neuron, with Scer\GAL4^ple.PF

(Varga et al., 2014)

larval dopaminergic DM neuron, with Scer\GAL4^ple.PF

(Varga et al., 2014)

lipid droplet | adult stage | increased number, with Scer\GAL4^GMR.PU

(Girard et al., 2021)

lipid droplet | adult stage | increased number, with Scer\GAL4^ninaE.PT

(Girard et al., 2021)

ommatidium | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

photoreceptor neuron | adult stage, with Scer\GAL4^GMR.PU

(Girard et al., 2021)

photoreceptor neuron | adult stage, with Scer\GAL4^ninaE.PT

(Girard et al., 2021)

retina, with Scer\GAL4^GMR.PF

(Feany and Bender, 2000)

retina | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

Detailed Description

Statement

Reference

Expressing Hsap\SNCA^A53T.UAS under the control of Scer\GAL4^elav.PLu leads to a progressive decrease in adult climbing ability.

(Agerschou et al., 2019)

The expression of Hsap\SNCA^A53T.UAS under the control of Scer\GAL4^GMR.long leads to progressive retinal generation: while 1-day old adults show normal retinal morphology, 30-days old adults show severe defects, namely apparent loss of photoreceptor neurons along with vacuole formation.

(Yan et al., 2019)

Expressing Hsap\SNCA^A53T.UAS under the control of Scer\GAL4^ple.PF induces a progressive decrease in adult climbing capacity and results in 21-days old adults raised at 29[o]C exhibiting significantly fewer PPL1 neurons than age-matched controls; there is no obvious effect on lifespan.

(Cunningham et al., 2018)

Flies expressing Hsap\SNCA^A53T.UAS under the control of Scer\GAL4^elav.PLu show progressive climbing defects.

(Saridaki et al., 2018)

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype in the adult eye and expression under the Scer\GAL4^Ddc.HL9 driver results in an age-progressive decrease in climbing abilities of adult flies.

(Alexopoulou et al., 2016)

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav.PLu exhibit a progressive reduction of locomotion in climbing assays.

(Dinter et al., 2016)

Adult flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF fed with 1% glucose show a significantly lower survival rate and loss of dopaminergic neurons in the PPM1/2 cluster (other dopaminergic neuronal clusters - VUM, PAL, PPM3, PPL1 and PPL2 - are unaffected) but their locomotion (climbing ability) at 0-5 days post-eclosion is not impaired relative to wild-type.

(Zhu et al., 2016)

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in a significant reduction in lifespan as compared to controls. These flies exhibit a significantly lower sedation time in response to acute ethanol exposure, and also show a significant longer recovery time, as compared to controls.

(Jahromi et al., 2015)

Flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav-C155 show defects in climbing ability. This phenotype is partially suppressed when the flies are fed the natural antioxidant decalepis hamiltonii (Dh). Climbing ability and early death are also seen when the flies are fed paraquat, and these phenotypes are both partly suppressed by Dh.

Locomotor rhythm and level of physical activity are disrupted in flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav-C155. This is partially suppressed when the flies are fed the natural antioxidant decalepis hamiltonii (Dh). Climbing ability and early death are also seen when the flies are fed paraquat, and these phenotypes are both partly suppressed by Dh.

(Jahromi et al., 2015)

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF does not result in a loss of dopaminergic neurons in 55-day old flies.

(Navarro et al., 2014)

Third instar larvae expressing Hsap\SNCA^{A53T.Scer\UAS} in dopaminergic neurons under the control of Scer\GAL4^ple.PF have significantly slower locomotion compared to wild type. This phenotype is exacerbated upon exposure to rotenone.

The brains of third instar larvae expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF have a decreased number of dopaminergic neurons in each of the three clusters (dorsomedial, dorsolateral 1 and dorsolateral 2). The phenotype is age-dependent; the number of DA neurons in first instar larvae is similar to wild type. A similar phenotype is seen when larvae expressing Hsap\SNCA^{A53T.Scer\UAS} are exposed to rotenone, but brain and body size are similar to wild type.

Third instar larvae expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF do not show any difference in olfaction compared to wild type.

(Varga et al., 2014)

Flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav-C155 show reduced climbing ability compared to age-matched controls from 9 days of age onwards. The severity of the defect increases with age. The severity of the defect is significantly reduced if the flies are raised on medium containing 0.75 mg/mL cinnamon extract precipitation.

(Shaltiel-Karyo et al., 2012)

Flies expressing Hsap\SNCA^{A53T.Scer\UAS} in dopaminergic neurons under the control of Scer\GAL4^ple.PF exhibit age-dependent neurodegeneration. No neuron loss is seen at days 15 or 25, but increased neurodegeneration compared to controls is seen at 40 days. No loss of dopaminergic neurons is seen in age-matched wild type flies.

No neurodegeneration is observed when Hsap\SNCA^{A53T.Scer\UAS} is expressed either in the photoreceptors under the control of Scer\GAL4^ninaE.PD, or in the small ventrolateral neurons (sLNvs) under the control of Scer\GAL4^P2.4.Pdf.

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF enhances the hypoxia-induced dopaminergic neuron degeneration seen in control flies.

(Botella et al., 2008)

Expression of Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF results in loss of dopaminergic neurons in aged brains.

(Cooper et al., 2006)

20 day old flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^Ddc.PL have a 50% reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain.

(Yang et al., 2003)

20 day old flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^Ddc.PL show marked loss of neurons in the dorsomedial dopaminergic clusters. Neuron loss is more variable in the dorsolateral-1 dopaminergic clusters, ranging from no loss of neurons to as much as 50% of neurons being lost.

(Auluck et al., 2002)

Flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav.PLu show a marked, age-dependent loss of dorsomedial dopaminergic neurons. Hsap\SNCA inclusions in the brain (detected by immunostaining) are seen in aged flies (the inclusions are first seen at 20-30 days of age). Most neuronal cytoplasmic inclusions are single, round and regular, although a few are more irregular. Neuritic Hsap\SNCA inclusions are also present in the brain and consist of both thread- and grain-like inclusions. Locomotor behaviour is grossly preserved in young flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav.PLu. These flies initially climb as well as wild-type flies, but over time they show a premature loss of climbing ability compared to control flies. Flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^GMR.PF show retinal degeneration that is detectable by 10 days, and marked at 30 days after eclosion.

(Feany and Bender, 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has abnormal locomotor rhythm | adult stage phenotype, suppressible by anne^KK107621, Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible | partially by Rab2^{Q65L.UASp.YFP}, Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by Rab2^{Q65L.UASp.YFP}, Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by Arl8^Q75L.UAS, Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

Hsap\SNCA^A53T.UAS, Scer\GAL4^elav.PLu has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Zzzz\β-wrapin^UAS.AS69, Scer\GAL4^elav.PLu

(Agerschou et al., 2019)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ple.PF has decreased cell number | adult stage phenotype, suppressible by st^UAS.Venus, Scer\GAL4^ple.PF

(Cunningham et al., 2018)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ple.PF has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by st^UAS.Venus, Scer\GAL4^ple.PF

(Cunningham et al., 2018)

Hsap\SNCA^A53T.UAS, Scer\GAL4^elav.PLu has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Hsap\FYCO1^UAS.cSa, Scer\GAL4^elav.PLu

(Saridaki et al., 2018)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.HL9 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by Usp8^HMS01898, Scer\GAL4^Ddc.HL9

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^elav.PLu has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Rab7^UAS.GFP, Scer\GAL4^elav.PLu

(Dinter et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ple.PF has abnormal neuroanatomy phenotype, suppressible by Mmus\Rab1a^UAS.cCa, Scer\GAL4^ple.PF

(Cooper et al., 2006)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has abnormal neuroanatomy phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

NOT suppressed by

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has short lived phenotype, non-suppressible by Arl8^Q75L.UAS, Scer\GAL4^Ddc.PL

(Szinyákovics et al., 2023)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by CG2224^KK101867, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Usp14^GLC01823, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Usp47^HMC02352, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Other

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has decreased cell number | adult stage phenotype

(Dhanushkodi et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^ninaE.PT has photoreceptor neuron | adult stage phenotype, suppressible by bmm^UAS.cGa, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ninaE.PT has lipid droplet | increased number | adult stage phenotype, suppressible by bmm^UAS.cGa, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has photoreceptor neuron | adult stage phenotype, suppressible by CG7900^KK106606, Scer\GAL4^GMR.PU

(Girard et al., 2021)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has lipid droplet | increased number | adult stage phenotype, suppressible by CG7900^KK106606, Scer\GAL4^GMR.PU

(Girard et al., 2021)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long has ommatidium | progressive phenotype, suppressible | partially by Ire1^GD3071, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long has retina | progressive phenotype, suppressible | partially by Ire1^GD3071, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long has ommatidium | progressive phenotype, suppressible | partially by Ire1^HMS03003, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long has retina | progressive phenotype, suppressible | partially by Ire1^HMS03003, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ple.PF has dopaminergic PPL1 neuron phenotype, suppressible by st^UAS.Venus, Scer\GAL4^ple.PF

(Cunningham et al., 2018)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.HL9 has dopaminergic PPM2 neuron | adult stage phenotype, suppressible | partially by Usp8^HMS01898/Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.HL9 has dopaminergic PPM1 neuron | adult stage phenotype, suppressible | partially by Usp8^HMS01898/Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^ple.PF has dopaminergic neuron phenotype, suppressible by Mmus\Rab1a^UAS.cCa, Scer\GAL4^ple.PF

(Cooper et al., 2006)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

NOT suppressed by

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-suppressible by CG2224^KK101867, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-suppressible by Usp14^GLC01823, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-suppressible by Usp47^HMC02352, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Other

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has adult dopaminergic neuron | decreased number phenotype

(Dhanushkodi et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype characteristic for adult flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^GMR.PU is restored by co-expression of Usp8^HMS01898 RNAi but not by expression of any of the following: CG2224^KK101867, Usp14^GLC01823 or Usp47^HMC02352.

The age-progressive decrease in climbing abilities of adult flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^Ddc.HL9 as well as the loss of neurons in the PPM1/2 cluster is partially or fully (respectively) rescued by co-expression of Usp8^HMS01898 RNAi. The climbing assay performance is not improved by co-expression of either CG3781^KK108083 or CG2224^KK101867.

(Alexopoulou et al., 2016)

Expression of Rab7^{Scer\UAS.T:Avic\GFP} does not alter lifespan or lead to a significant difference in the the locomotion activity of flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav.PLu at 5 days old, however, at 15 and 25 days old results in significantly improved locomotion, delaying the onset of locomotion defects seen in flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^elav.PLu.

(Dinter et al., 2016)

The loss of dopaminergic neurons that is seen in the brains of flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^ple.PF is suppressed by co-expression of Mmus\Rab1^Scer\UAS.cCa.

(Cooper et al., 2006)

The reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain seen in 20 day old flies expressing Hsap\SNCA^{A53T.Scer\UAS} under the control of Scer\GAL4^Ddc.PL is suppressed by coexpression of Hsap\PARK2^Scer\UAS.cYa.

(Yang et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8148

w^*; P{UAS-Hsap\SNCA.A53T}CG7900^15.3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hsap\SNCA^{A53T.Scer\UAS}

Hsap\SNCA^A53T.UAS

Syn^A53T

(Alexopoulou et al., 2016)

αSyn^A53T

(Yan et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (36)

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