FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ptenunspecified
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General Information
Symbol
Dmel\Ptenunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0122010
Feature type
allele
Associated gene
Dmel\Pten
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Although individual cell polarization is similar in wild-type and Ptenunspecified mutant pupal wing cells, the global tissue planar cell polarity relative to the proximal-distal axis is significantly affected in the mutant.

        (Bardet et al., 2013)

        Animals containing mutant eye discs generated using the eyFLP-cell lethal system eclose, and have reduced eyes.

        (Menut et al., 2007)

        Wing disc cells are larger than normal in mutants.

        (Tang et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Ptenunspecified has lethal | recessive | larval stage phenotype, suppressible by Akt04226/Akt3

        (Stocker et al., 2002)

        Ptenunspecified has lethal | recessive | larval stage phenotype, suppressible by Akt1/Akt3

        (Stocker et al., 2002)

        Ptenunspecified has lethal | recessive | larval stage phenotype, suppressible by Akt3/Akt3

        (Stocker et al., 2002)
        NOT suppressed by
        Statement
        Reference

        Ptenunspecified has lethal | recessive | larval stage phenotype, non-suppressible by Akt1

        (Stocker et al., 2002)

        Ptenunspecified has lethal | recessive | larval stage phenotype, non-suppressible by Akt04226

        (Stocker et al., 2002)
        NOT Enhancer of
        Statement
        Reference

        Ptenunspecified/Pten[+] is a non-enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        Ptenunspecified/Pten[+] is a non-suppressor of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Other
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Ptenunspecified/Pten[+] is a non-enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        Ptenunspecified/Pten[+] is a non-suppressor of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Ptenunspecified flies rescued by the combination Akt11/Akt13 are wild-type in size. Ptenunspecified ; Akt11/Akt13 flies have essentially normal ommatidia and rhabdomeres in the eye and the wings show normal venation.

        (Stocker et al., 2002)

        Wing disc cells doubly mutant for lilli and Pten enlarge to the same extent as Pten single mutant cells. Ommatidia of this genotype are disorganised.

        (Tang et al., 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Ptenunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (6)