FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lrev6-3
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General Information
Symbol
Dmel\Lrev6-3
Species
D. melanogaster
Name
FlyBase ID
FBal0144763
Feature type
allele
Associated gene
Dmel\L
Associated Insertion(s)
roo{}L-2
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Son and Choi, 2020, Chern and Choi, 2002)
Mutagen
gamma ray
(Chern and Choi, 2002)
Progenitor genotype
L2
(Son and Choi, 2020)
Associated Insertion(s)
roo{}L-2
Cytology
Description

18bp in-frame deletion; removes six amino acid residues (MQLHLA) within the 10th zinc-finger motif (this is within a putative Mad protein-binding motif).

(Son and Choi, 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:14,463,294..14,463,311 [+]
Comment:

18bp in-frame deletion; removes six amino acid residues (MQLHLA) within the 10th zinc-finger motif of L.

(Son and Choi, 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      40-80% of heterozygotes have weak eye phenotypes, such as small dents in the anterior part of the eye.

      (Son and Choi, 2020)

      Lrev6-3 mutant eye clones exhibit a domain specific phenotype. Loss-of-function Lrev6-3 clones in the ventral eye result in the selective loss of eye fate. However, in the dorsal eye these clones have no effect on the eye fate.

      (Singh et al., 2011)

      Lfee/Lrev6-3 trans-heterozygotes have smaller eyes than Lfee alone.

      (Wang and Huang, 2009)

      Lrev6-3 clones in they eye disc show TUNEL-positive cells in the ventral eye (indicating cell death), while cells in the dorsal half of the eye are not affected.

      (Singh et al., 2006)

      Heterozygotes have normal eyes. Homozygous clones in the eye result in elimination of the ventral eye, but have no effect in the dorsal eye.

      (Singh et al., 2005)

      Homozygous clones in the dorsal part of the eye do not affect ommatidial development. Homozygous clones in the ventral part of the eye inhibit ommatidial development. Homozygous clones generated during the first larval instar can completely eliminate eye fate in the eye-antennal disc, whereas antennal development in the same disc is unaffected.

      (Singh and Choi, 2003)

      Homozygous embryos fail to complete germ band retraction and show no cuticle formation. Homozygous clones in the ventral part of eye disc, induced during the first larval instar, result in a large reduction of the ventral part of the eye disc in the third larval instar, with the surrounding heterozygous tissue and wild-type clonal tissue generally disappearing together with the homozygous clonal tissue. This results in adult eyes in which most of the ventral region of the eye is replaced by the cuticle. Homozygous clones of considerable size in the dorsal part of the eye disc, induced during the first larval instar, do not cause any obvious reduction in size of the dorsal part of the eye disc, and photoreceptor differentiation and polarity appears unaffected by these clones. Homozygous clones induced in ventral or dorsal regions of the eye disc during the late second and the third larval instars do not result in any obvious eye defects.

      (Chern and Choi, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Statement
      Reference

      L[+]/Lrev6-3 is a suppressor of visible | somatic clone phenotype of pnrVX6

      (Singh et al., 2005)
      Other
      Statement
      Reference

      Df(2R)ED2354, Lrev6-3 has viable phenotype

      (Pallares-Cartes et al., 2012)

      Lrev6-3, sgg[+]/sgg1 has visible | dominant phenotype

      (Singh et al., 2005)

      L[+]/Lrev6-3, sgg1 has visible phenotype

      (Singh et al., 2005)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Lrev6-3 has phenotype, non-enhanceable by phyl[+]/phyl2366

      (Son and Choi, 2020)

      Lrev6-3 has phenotype, non-enhanceable by phyl[+]/phyl2245

      (Son and Choi, 2020)
      Suppressed by
      Statement
      Reference

      Lrev6-3 has eye | somatic clone phenotype, suppressible by hth[+]/hthMeis1-P2

      (Singh et al., 2011)

      Lrev6-3 has eye disc | somatic clone phenotype, suppressible by hth[+]/hthMeis1-P2

      (Singh et al., 2011)

      Lrev6-3 has eye | somatic clone phenotype, suppressible by hth[+]/hth100-1

      (Singh et al., 2011)

      Lrev6-3 has eye disc | somatic clone phenotype, suppressible by hth[+]/hth100-1

      (Singh et al., 2011)

      Lrev6-3 has eye disc | ventral | somatic clone phenotype, suppressible by Scer\GAL4ey.PH/sggS9A.UAS

      (Singh et al., 2006)

      Lrev6-3 has eye disc | ventral | somatic clone phenotype, suppressible by panΔN.UAS/Scer\GAL4ey.PH

      (Singh et al., 2006)

      Lrev6-3 has eye | ventral | somatic clone phenotype, suppressible by pnr[+]/pnrVX6

      (Singh et al., 2005)
      NOT suppressed by
      Statement
      Reference

      Lrev6-3 has phenotype, non-suppressible by phyl[+]/phyl2366

      (Son and Choi, 2020)

      Lrev6-3 has phenotype, non-suppressible by phyl[+]/phyl2245

      (Son and Choi, 2020)
      Suppressor of
      Statement
      Reference

      L[+]/Lrev6-3 is a suppressor of eye | dorsal | somatic clone phenotype of pnrVX6

      (Singh et al., 2005)
      Other
      Statement
      Reference

      Lrev6-3, sgg[+]/sgg1 has eye | ventral phenotype

      (Singh et al., 2005)

      Lrev6-3, sgg1 has eye | ventral phenotype

      (Singh et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Lrev6-3 heterozygous eye clones in a hth100-1 or hthMeis1-P2 heterozygous background results in no ventral eye loss and a wild-type eye phenotype.

      (Singh et al., 2011)

      Expression of either sggS9A.Scer\UAS or panΔN.Scer\UAS, under the control of Scer\GAL4ey.PH, in Lrev6-3 clones suppresses the loss of ventral cells in the eye disc.

      (Singh et al., 2006)

      sgg1/+ ; Lrev6-3/+ flies show loss of the ventral eye. The dorsal eye enlargements caused by homozygous pnrVX6 clones are no longer seen in the flies are also carrying Lrev6-3/+.

      (Singh et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Lunspecified

      (Chern and Choi, 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Lrev6-3
      (Son and Choi, 2020, Pallares-Cartes et al., 2012, Singh et al., 2011, Wang and Huang, 2009, Singh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)