FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sesBG0386
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General Information
Symbol
Dmel\sesBG0386
Species
D. melanogaster
Name
FlyBase ID
FBal0151495
Feature type
allele
Associated gene
Dmel\sesB
Associated Insertion(s)
P{lacW}Ant2G0386
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.12.2)
Progenitor genotype
Associated Insertion(s)
P{lacW}Ant2G0386
Cytology
Description

Insertion within the sesB coding region.

(Rikhy et al., 2003)

The P{lacW} insertion maps within both Ant2 and sesB (transcription units with non-overlapping ORFs which share untranslated sequences).

(FlyBase, 1996-)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mosaic animals in which the eye tissue is homozygous for sesBG0386 show do not show eye formation. 2% of the expected number of sesBG0386/sesBorg flies survive to adulthood.

      (Rikhy et al., 2003)

      FlyBase curator comment: the P{lacW} insertion results in homozygous lethality, but since the insertion is within both the Ant2 and sesB transcription units, it is unclear whether the lethality is due to an effect on Ant2 or sesB (or both).

      (Peter et al., 2002, Schäfer et al., 1999.12.2)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sesBorg

      (Rikhy et al., 2003)
      Rescued by

      sesBG0386 is rescued by sesB+t10.3

      (Rikhy et al., 2003)

      sesBorg/sesBG0386 is rescued by sesB+t10.3

      (Rikhy et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: an additional separable lethal mutation (the lethality of the original "P2251" line is not rescued by sesB+t10.3, but a recombinant, "P(3)org", has been obtained that can survive in the presence of one copy of sesB+t10.3 but otherwise has identical phenotypes to the original "P2251" line).

      (Rikhy et al., 2003)
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.12.2)

      Precise excision of the P-element reverts the mutant phenotype.

      (Rikhy et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      P(3)org
      (Rikhy et al., 2003)
      P2251
      (Rikhy et al., 2003)
      l(1)G0386
      (Peter et al., 2002)
      l(1)G0386G0386
      sesBG0386
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0103737
      References (4)