FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dop1R1PL00420
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General Information
Symbol
Dmel\Dop1R1PL00420
Species
D. melanogaster
Name
FlyBase ID
FBal0160601
Feature type
allele
Associated gene
Dmel\Dop1R1
Associated Insertion(s)
PBac{GAL4D,EYFP}Dop1R1PL00420
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bang et al., 2011)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
PBac{GAL4D,EYFP}Dop1R1PL00420
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{GAL4D,EYFP}
Encoded product / tool
GAL4(II-9)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sensitivity to ethanol-induced sedation is not affected in Dop1R1PL00420 mutant adults.

      (Petruccelli et al., 2016)

      Homozygotes show abnormal temperature-preference behaviour; their avoidance index against low temperatures is less than 50% of wild type.

      DopRPL00420/Df(3R)red-P52 flies show abnormal temperature-preference behaviour; their avoidance index against low temperatures is only 23% of wild type.

      (Bang et al., 2011)

      Homozygous DopRPL00420 mutants show reduced ethanol-induced hyperactivity. Without ethanol stimulation, activity is unaffected in DopRPL00420 homozygotes.

      (Kong et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Dop1R1PL00420 is a suppressor | partially of chemical resistant | adult stage phenotype of DopEcRGAL4

      (Petruccelli et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased resistance to ethanol-induced sedation characteristic for DopEcRGAL4 homozygous adults is not suppressed by combination with DATfmn.

      (Petruccelli et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dop1R1PL00420 is rescued by Scer\GAL4c309/Dop1R1UAS.cBa

      (Bang et al., 2011)

      Dop1R1PL00420 is rescued by Scer\GAL4Mef2.247/Dop1R1UAS.cBa

      (Bang et al., 2011)

      Dop1R1PL00420 is rescued by Scer\GAL4c739/Dop1R1UAS.cBa

      (Bang et al., 2011)
      Not rescued by

      Dop1R1PL00420 is not rescued by Scer\GAL41471/Dop1R1UAS.cBa

      (Bang et al., 2011)

      Dop1R1PL00420 is not rescued by Scer\GAL4smid-C161/Dop1R1UAS.cBa

      (Bang et al., 2011)

      Dop1R1PL00420 is not rescued by Scer\GAL4OK348/Dop1R1UAS.cBa

      (Bang et al., 2011)
      Comments

      Expression of DopRScer\UAS.cBa under the control of either Scer\GAL4c309, Scer\GAL4c739 or Scer\GAL4Mef2.247 restores normal temperature-preference behaviour in homozygous DopRPL00420 flies.

      Expression of DopRScer\UAS.cBa under the control of either Scer\GAL41471, Scer\GAL4OK348 or Scer\GAL4smid-C161 does not rescue normal temperature-preference behaviour in homozygous DopRPL00420 flies.

      (Bang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dop1R1PL00420
      DopRPL00420
      (Petruccelli et al., 2016)
      PL00420
      (Zhang et al., 2016)
      dumb3
      (Bang et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)