FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\mTorE161K
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General Information
Symbol
Dmel\mTorE161K
Species
D. melanogaster
Name
FlyBase ID
FBal0189881
Feature type
allele
Associated gene
Dmel\mTor
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zhang et al., 2006)
Mutagen
ethyl methanesulfonate
(Zhang et al., 2006)
Progenitor genotype
Cytology
Description

Mutation is within the HEAT-repeat domain of the Tor protein.

(Zhang et al., 2006)

Amino acid replacement: E161K.

(Zhang et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:13,005,464..13,005,464 [+]
Nucleotide change:

G13005464A

Amino acid change:

E161K | mTor-PA; E161K | mTor-PB

Reported amino acid change:

E161K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhang et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      5-15% of TorE161K mutants are able to survive to adulthood. These escapers are about half the size of wild type and are developmentally delayed by 2 days at 25oC. Escaper flies are 10:1 female:male and both genders are sterile. Ovaries dissected from TorE161K females display arrested development and increased cell death at a previtellogenic stage. Testes are abnormal and have a grossly enlarged apical tip.

      (Zhang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Suppressor of
      Statement
      Reference

      mTorE161K/mTor[+] is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of GluRIIASP16/Df(2L)cl-h4

      (Penney et al., 2012)

      mTorE161K/Tor[+] is a suppressor | partially of lethal | larval stage phenotype of gig193/gig109

      (Zhang et al., 2006)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ~30% of TorE161K/+; gig109/gig193 flies survive to adulthood, while no gig109/gig193 survive to the pupal stage.

      (Zhang et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that is lethal in trans to the TorΔP deletion.

      (Zhang et al., 2006)
      Comments
      Comments

      The TorE161K chromosome carries a second lethal mutation.

      (Zhang et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TorE161K
      (Penney et al., 2012)
      mTorE161K
      Name Synonyms
      Secondary FlyBase IDs
        References (2)