FlyBase Allele Report: Dmel\p53[GD4483]

General Information

Symbol

Dmel\p53^GD4483

Species

D. melanogaster

Name

FlyBase ID

FBal0210284

Feature type

allele

Associated gene

Dmel\p53

Associated Insertion(s)

Carried in Construct

P{GD4483}

Also Known As

UAS-dp53^RNAi, UAS-p53^RNAi, Dp53-i

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4483}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4483

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intestinal cancer

CEA with Apc^GD1333, Ras85D^V12.cUa.UAS

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS

(Quintero and Bangi, 2023)

model of cancer

CEA with Myc^UAS.cZa

(Diaz et al., 2024)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult fat body | nutrition conditional, with Scer\GAL4^ppl.PP

(Barrio et al., 2014)

lipid droplet | nutrition conditional, with Scer\GAL4^ppl.PP

(Barrio et al., 2014)

wing disc | third instar larval stage, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

Detailed Description

Statement

Reference

The expression of p53^GD4483 for 3 days during larval development under the combined control of Scer\GAL4^hh.PU and Gal80[ts] induces abundant apoptosis (Dcp1 immunostaining) in third instar larval wing discs.

(Murcia et al., 2019)

Expression of p53^GD4483 under the control of any of three fat body drivers (Scer\GAL4^ppl.PP, Scer\GAL4^cg.PU or Scer\GAL4^yolk) results in reduced survival rates upon adult nutrient deprivation when compared to controls. Expressing p53^GD4483 in muscles under the control of Scer\GAL4^Mef2.PR has no effect on survival rates upon fasting.

Fat-body specific expression of p53^GD4483 under the control of Scer\GAL4^ppl.PP causes an accelerated consumption of energy resources following fasting; triacylglycerides (TAGs) and glycogen are consumed at an accelerated rate compared to controls and the levels of total sugar are also reduced. Levels of circulating sugars are unaffected. The levels of TAGS, glycogen and sugars are largely similar in p53-depleted and control animals prior to starvation. The lipid droplets in fat body cells are smaller than in starved control flies. No significant change in lipid droplet size is observed in well-fed fat body cells expressing p53^GD4483.

(Barrio et al., 2014)

Expression of p53^GD4483 under the control of Scer\GAL4^ple.PF does not lead to a significant difference in survival or climbing capability as compared to controls under normal conditions; however, these flies exhibit increased resistance to paraquat toxicity, with a significant increase in survival and climbing performance when exposed to paraquat, as compared to control flies exposed to the same treatment.

(Ortega-Arellano et al., 2013)

Adults expressing p53^GD4483 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4483

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Scer\GAL4^hh.PU, p53^GD4483 has increased cell death | third instar larval stage phenotype, suppressible | partially by Ras85D^V12.UAS, Scer\GAL4^hh.PU

(Murcia et al., 2019)

NOT suppressed by

Statement

Reference

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

NOT Enhancer of

Statement

Reference

p53^GD4483, Scer\GAL4^ey.PH is a non-enhancer of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

p53^GD4483, Scer\GAL4^ey.PH is a non-enhancer of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/p53^GD4483 is a suppressor of increased cell death | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Scer\GAL4^elav.PU/p53^GD4483 is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^elav.PU, rl^GD4697

(Murcia et al., 2019)

Scer\GAL4^elav.PU/p53^GD4483 is a suppressor of visible | adult stage phenotype of Scer\GAL4^elav.PU, rl^GD4697

(Murcia et al., 2019)

p53^GD4483, Scer\GAL4^nub.PU is a suppressor | partially of visible | adult stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

p53^GD4483, Scer\GAL4^nub.PU is a suppressor | partially of abnormal size | adult stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

NOT Suppressor of

Statement

Reference

p53^GD4483/rl^GD4697, Scer\GAL4^hh.PU is a non-suppressor of decreased cell death | third instar larval stage | conditional phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU

(Murcia et al., 2019)

p53^GD4483, Scer\GAL4^nub.PU is a non-suppressor of increased cell death | third instar larval stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

Other

Statement

Reference

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Scer\GAL4^hh.PU, p53^GD4483 has wing disc | third instar larval stage phenotype, suppressible | partially by Ras85D^V12.UAS, Scer\GAL4^hh.PU

(Murcia et al., 2019)

NOT suppressed by

Statement

Reference

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, non-suppressible by Pten^RNAi.UAS.cUa, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

NOT Enhancer of

Statement

Reference

p53^GD4483, Scer\GAL4^ey.PH is a non-enhancer of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/p53^GD4483 is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Scer\GAL4^elav.PU/p53^GD4483 is a suppressor of eye phenotype of Scer\GAL4^elav.PU, rl^GD4697

(Murcia et al., 2019)

p53^GD4483, Scer\GAL4^nub.PU is a suppressor | partially of wing phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

NOT Suppressor of

Statement

Reference

p53^GD4483/rl^GD4697, Scer\GAL4^hh.PU is a non-suppressor of wing disc | third instar larval stage | conditional phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU

(Murcia et al., 2019)

p53^GD4483, Scer\GAL4^nub.PU is a non-suppressor of wing disc | third instar larval stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

Other

Statement

Reference

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enterocyte | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enterocyte | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The extensive cell death in the pouch region of wing discs in third instar larvae as well as the small and deformed wings in adults expressing His1:CG31617^NIG.31617R under the control of Scer\GAL4^nub.PU are not suppressed by co-expression of p53^GD4483.

(Bayona-Feliu et al., 2017)

Xenogenetic Interactions

Statement

Reference

The increase in the number of TUNEL-positive cells and the non-autonomous increase in BrdU incorporation seen in the wing discs in larvae expressing Rcom\RA^cs2.Scer\UAS under the control of Scer\GAL4^en-e16E at 30[o]C is largely suppressed by co-expression of p53^GD4483.

Co-expression of p53^GD4483 does not rescue the autonomous reduction in wing area caused by expression of Rcom\RA^cs2.Scer\UAS under the control of Scer\GAL4^en-e16E, but it does rescue the non-autonomous reduction in wing area caused by expression of Rcom\RA^cs2.Scer\UAS under the control of Scer\GAL4^en-e16E.

(Mesquita et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v10692

w¹¹¹⁸; P{GD4483}v10692

v38235

w¹¹¹⁸; P{GD4483}v38235