FlyBase Allele Report: Dmel\pelo[GD11173]

General Information

Symbol

Dmel\pelo^GD11173

Species

D. melanogaster

Name

FlyBase ID

FBal0210318

Feature type

allele

Associated gene

Dmel\pelo

Associated Insertion(s)

Carried in Construct

P{GD11173}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11173}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11173

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

elongation stage spermatid, with Scer\GAL4^{VP16.nanos.UTR}

(Li et al., 2019)

spermatocyte, with Scer\GAL4^{VP16.nanos.UTR}

(Yang et al., 2015)

sperm individualization complex, with Scer\GAL4^{VP16.nanos.UTR}

(Li et al., 2019)

Detailed Description

Statement

Reference

Expressing pelo^GD11173 under the control of Scer\GAL4^VP16.nos.UTR induces spermatogenesis defects, as shown by defects in the organization of individualization complexes and a significant decrease in the number of relatively normal-sized individualization complexes, as compared to controls.

(Li et al., 2019)

Expression of pelo^GD11173 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} leads to formation of abnormal Ste protein crystals in spermatocytes.

(Yang et al., 2015)

Adults expressing pelo^GD11173 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing pelo^GD11173 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development