FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1B17-1
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General Information
Symbol
Dmel\Dscam1B17-1
Species
D. melanogaster
Name
FlyBase ID
FBal0213020
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
Also Known As
DscamB17-1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Wang et al., 2004)
Progenitor genotype
Dscam105518
(Wang et al., 2004)
Cytology
Description

Imprecise excision of the insertion in Dscam05518, resulting in a deletion of sequences in the Dscam exon 4 cluster.

(Wang et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Down syndrome
      CEA with Dscam121
      (Huang et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1, Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      abnormal locomotor behavior | adult stage (with Dscam121), with Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1, Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      abnormal neuroanatomy | adult stage (with Dscam121), with Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      abnormal neuroanatomy | larval stage (with Dscam121)

      (Huang et al., 2011)

      abnormal neuroanatomy | somatic clone

      (Wang et al., 2004)

      lethal | recessive

      (Wang et al., 2004)

      lethal - all die before end of larval stage (with Dscam118)

      (Wang et al., 2004)

      lethal - all die before end of P-stage (with Dscam121)

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1, Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      short lived (with Dscam121), with Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      some die during larval stage (with Dscam118)

      (Wang et al., 2004)

      visible (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      visible (with Dscam121), with Dscam1B1.4.2-6.18-9.22-17.1, Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      visible (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      visible (with Dscam121), with Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      visible (with Dscam121), with Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      visible (with Dscam121), with Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most Dscam121/Dscam1B17-1 mutants die at early larval stages, with the remainder dying before eclosion, and dendritic arborization neurons exhibit self-avoidance defects.

      Surviving adults of Dscam121/Dscam1B17-1 mutants expressing Dscam1B1.4.2-6.18-9.22-17.1, Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1, Dscam1C2.4.2-6.14-9.24-17.2, both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, are largely immobile, have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

      (Huang et al., 2011)

      Single cell clones of mushroom body α/β neurons that are homozygous for DscamB17-1 show axon branching defects, such as the generation of additional branches.

      (Wang et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT/Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT/Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT/Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT/Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT/Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT/Hsap\DSCAMDscam1.WT

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT/Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1Dscam1.WT/Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAMDscam1.WT/Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)
      NOT suppressed by
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of both Hsap\DSCAML1Dscam1.WT and Hsap\DSCAMDscam1.WT, or both Hsap\DSCAMDscam1.WT and Dscam1B1.4.2-6.18-9.22-17.1, or both Hsap\DSCAMDscam1.WT and Dscam1C1.4.2-6.14-9.24-17.1, or both Hsap\DSCAML1Dscam1.WT and Dscam1B1.4.2-6.18-9.22-17.1, or both Hsap\DSCAML1Dscam1.WT and Dscam1C1.4.2-6.14-9.24-17.1, partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

      Expression of Hsap\DSCAML1Dscam1.WT or Hsap\DSCAMDscam1.WT largely rescues the dendritic arborization neuron self-avoidance defects, and partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging. The majority of these adults are immobile and have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

      Expression of Hsap\DSCAMT.Dscam1.T:Avic\GFP or Hsap\DSCAML1T.Dscam1.T:Avic\GFP fails to rescue the larval lethality of Dscam121/Dscam1B17-1 mutants.

      Expression of both Hsap\DSCAMDscam1.WT and Dscam1B2.4.2-6.18-9.22-17.2, or both Hsap\DSCAMDscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, or both Hsap\DSCAML1Dscam1.WT and Dscam1B2.4.2-6.18-9.22-17.2, or both Hsap\DSCAML1Dscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, substantially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with a majority of mutants developing to late pupal stages.

      (Huang et al., 2011)
      Complementation and Rescue Data
      Partially rescued by

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1B2.4.2-6.18-9.22-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1B2.4.2-6.18-9.22-17.2/Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1C2.4.2-6.14-9.24-17.2/Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1A1.4.3-6.36-9.25-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1A2.4.3-6.36-9.25-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1C1.4.2-6.14-9.24-17.1/Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1B2.4.2-6.18-9.22-17.2/Dscam1B1.4.2-6.18-9.22-17.1

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1B2.4.2-6.18-9.22-17.2/Dscam1C2.4.2-6.14-9.24-17.2

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is partially rescued by Dscam1C2.4.2-6.14-9.24-17.2/Dscam1C1.4.2-6.14-9.24-17.1

      (Huang et al., 2011)

      Dscam118/Dscam1B17-1 is partially rescued by Dscam14.3-6.36-9.25-17.2

      (Wang et al., 2004)
      Not rescued by

      Dscam121/Dscam1B17-1 is not rescued by Dscam1C1T.4.2-6.14-9.24-17.1.GFP

      (Huang et al., 2011)

      Dscam121/Dscam1B17-1 is not rescued by Dscam1C2T.4.2-6.14-9.24-17.2.GFP

      (Huang et al., 2011)

      Dscam118/Dscam1B17-1 is not rescued by Dscam14.3-6.36-9.25-17.1

      (Wang et al., 2004)
      Comments

      Expression of Dscam1A1.4.3-6.36-9.25-17.1, Dscam1A2.4.3-6.36-9.25-17.2, Dscam1B1.4.2-6.18-9.22-17.1, Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C2.4.2-6.14-9.24-17.2, partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

      Expression of Dscam1C1.4.2-6.14-9.24-17.1 partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging; and largely rescues the dendritic arborization neuron self-avoidance defects of Dscam121/Dscam1B17-1 mutants.

      Expression of both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, or both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1C1.4.2-6.14-9.24-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, almost completely rescues the lethality of Dscam121/Dscam1B17-1 mutants, with most mutants developing to pupal stage.

      Expression of Dscam1C2.4.2-6.14-9.24-17.2 partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging, but fails to rescue the dendritic arborization neuron self-avoidance defects of Dscam121/Dscam1B17-1 mutants.

      Expression of Dscam1C1T.4.2-6.14-9.24-17.1.T:Avic\GFP or Dscam1C2T.4.2-6.14-9.24-17.2.T:Avic\GFP fails to rescue the larval lethality of Dscam121/Dscam1B17-1 mutants.

      (Huang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      B17-1
      (Wang et al., 2004)
      Dscam1B17-1
      DscamB17-1
      (Han et al., 2012, Huang et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)