FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Fer2MB09480
Open Close
General Information
Symbol
Dmel\Fer2MB09480
Species
D. melanogaster
Name
FlyBase ID
FBal0219528
Feature type
allele
Associated gene
Dmel\Fer2
Associated Insertion(s)
Mi{ET1}Fer2MB09480
Carried in Construct
Also Known As
Fer22
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Bou Dib et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}Fer2MB09480
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Parkinson's disease
        CEA
        (Tas et al., 2018)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Parkinson's disease 8
        modeled by LrrkI1915T.UAS
        (Miozzo et al., 2022)
        modeled by LrrkUAS.cIa
        (Miozzo et al., 2022)
        model of  Parkinson's disease
        is ameliorated by foxoUAS.cFa
        (Tas et al., 2018)
        is exacerbated by Fer2RNAi.UAS.5
        (Tas et al., 2018)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Fer2MB09480 homozygous adults show a decrease in the number of PAM neurons.

        (Miozzo et al., 2022)

        Fer2MB09480 homozygous adults show significant decreases in lifespan and in locomotor capacity (in a startle-induced climbing assay) and a significant and progressive decrease in the number of autophagosomes (i.e. Atg-8-positive puncta) in the PAM neuron region in the adult brain, as compared to heterozygous and wild-type controls.

        (Tas et al., 2018)

        The number of PAM dopaminergic neurons is slightly reduced in Fer2MB09480 mutant flies on eclosion, and neuron loss continues progressively at least up to 28 days.

        The majority of visible mitochondria in the cell bodies of remaining PAM neurons in Fer2MB09480 mutant flies are in enlarged aggregations and do not form tubular networks as in th control flies.

        Reactive oxygen levels (ROS) are significantly elevated throughout the brain in 5-day old Fer2MB09480 mutant flies compared with age-matched controls. ROS levels are elevated in PAM dopaminergic neurons. Feeding flies a non-lethal dose of hydrogen peroxide significantly decreases the number of PAM dopaminergic neurons in Fer2MB09480 homozygotes, but not in heterozygotes. Other dopaminergic neuron clusters are unaffected in both homozygotes and heterozygotes.

        (Bou Dib et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Suppressed by
        Enhancer of
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The expression of foxoUAS.cFa under the control of Scer\GAL4GMR58E02 partially suppresses the progressive decrease in the number of adult PAM neurons and the decreased adult locomotion capacity observed in Fer2MB09480 homozygotes, while further reducing their decreased lifespan.

        (Tas et al., 2018)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Fer2MB09480 is rescued by Fer2UAS.Tag:FLAG/Scer\GAL4Fer2.2359

        (Bou Dib et al., 2014)
        Partially rescued by

        Fer2MB09480 is partially rescued by Fer2UAS.Tag:FLAG/Scer\GAL4GMR58E02

        (Bou Dib et al., 2014)
        Comments

        Expression of Fer2Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Fer2.2359 fully rescues the climbing defects seen in Fer2MB09480 mutant flies. The PAM dopaminergic loss is also rescued.

        Expression of Fer2Scer\UAS.T:Zzzz\FLAG in PAM neurons under the control of either Scer\GAL4GMR58E02 partially rescues the PAM neuron loss in Fer2MB09480 mutant flies. The climbing defects are also partially rescued.

        (Bou Dib et al., 2014)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Fer22
        (Miozzo et al., 2022, Tas et al., 2018, Bou Dib et al., 2014)
        Fer2MB09480
        (Bou Dib et al., 2014, Bellen, 2008.12.12)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)