FlyBase Allele Report: Dmel\Stat92E[KK100519]

General Information

Symbol

Dmel\Stat92E^KK100519

Species

D. melanogaster

Name

FlyBase ID

FBal0230802

Feature type

allele

Associated gene

Dmel\Stat92E

Associated Insertion(s)

Carried in Construct

P{KK100519}

Also Known As

UAS-STAT92E-RNAi, UAS-STAT^RNAi, UAS-STAT92E-IR, UAS::Stat^RNAi, UAS-stat92E^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100519}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100519

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by l(2)gl^GD4047

(Tamori et al., 2016)

ameliorates hematologic cancer

modeled by hop^{UAS.ORF.Tag:HA}

(Terriente-Félix et al., 2017)

ameliorates acute myeloid leukemia

modeled by Mmus\Tet2^{R1261C.UAS.Tag:FLAG}

(Ismail et al., 2023)

ameliorates carcinoma

modeled by l(2)gl^GD4047

(Chatterjee et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4²²¹

(Mahata et al., 2025)

abnormal size | adult stage, with Scer\GAL4^sd.PU

(Recasens-Alvarez et al., 2017)

abnormal wound healing | larval stage, with Scer\GAL4²²¹

(Mahata et al., 2025)

visible | adult stage, with Scer\GAL4^sd.PU

(Recasens-Alvarez et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Stat92E^KK100519 under the control of Scer\GAL4^ptc.PU non-autonomously induces ectopic wing structures in third instar larval wing discs, a compared to controls. Expression under the control of Scer\GAL4^sd.PU leads to vestigial or absent wings and to the reciprocal formation of ectopic mesonotum structures, as compared to controls.

(Recasens-Alvarez et al., 2017)

The expression of Stat92E^KK100519 under the control of Scer\GAL4^ey.PH does not have an obvious effect on the adult eye size compared to controls.

(Clemente-Ruiz et al., 2016)

The clonal expression of Stat92E^KK100519 under the control of Scer\GAL4^Act5C.PI does not lead to any obvious third instar larval wing disc phenotype, as compared to controls.

(Tamori et al., 2016)

Expression of Stat92E^KK100519 under the control of Scer\GAL4^Bx-MS1096 has no effect on male wing size or patterning.

Expression of Stat92E^KK100519 under the control of Scer\GAL4^Bx-MS1096 has no effect on female wing size or patterning.

(Schertel et al., 2015)

Expression of Stat92E^KK100519 RNAi under the control Scer\GAL4^Hml.Δ driver does not rescue the lowered survival of adult flies on lard-supplemented diet compared to controls.

(Woodcock et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Stat92E^KK100519, Scer\GAL4^{Tet-MI05009-GAL4} is an enhancer of increased cell number | larval stage phenotype of Mmus\Tet2^UAS.Tag:FLAG, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Stat92E^KK100519, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^KK100519, Scer\GAL4^ey.PH is an enhancer of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^KK100519, Scer\GAL4^ey.PH is an enhancer of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Suppressor of

Statement

Reference

Stat92E^KK100519, Scer\GAL4^{Tet-MI05009-GAL4} is a suppressor | partially of increased cell number | larval stage phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Scer\GAL4^Act5C.PI/Stat92E^KK100519 is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, l(2)gl^GD4047

(Tamori et al., 2016)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, Stat92E^KK100519 has wing pouch | ectopic | third instar larval stage phenotype, non-suppressible by wg^HMS00844/Scer\GAL4^ptc.PU

(Recasens-Alvarez et al., 2017)

Enhancer of

Statement

Reference

Stat92E^KK100519, Scer\GAL4^{Tet-MI05009-GAL4} is an enhancer of embryonic/larval hemocyte | larval stage | increased number phenotype of Mmus\Tet2^UAS.Tag:FLAG, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Stat92E^KK100519, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Suppressor of

Statement

Reference

Stat92E^KK100519, Scer\GAL4^{Tet-MI05009-GAL4} is a suppressor | partially of embryonic/larval hemocyte | increased number | larval stage phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Scer\GAL4^Act5C.PI/Stat92E^KK100519 is a suppressor of wing disc | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, l(2)gl^GD4047

(Tamori et al., 2016)

Scer\GAL4^Act5C.PI/Stat92E^KK100519 is a suppressor of wing hinge primordium | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, l(2)gl^GD4047

(Tamori et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic wing structures in third instar larval wing discs induced by the expression of Stat92E^KK100519 under the control of Scer\GAL4^ptc.PU is not suppressed by the co-expression of wg^HMS00844.

(Recasens-Alvarez et al., 2017)

The co-expression of Stat92E^KK100519 suppresses the wing disc hinge overgrowths induced by the clonal expression of l(2)gl^GD4047 under the control of Scer\GAL4^Act5C.PI (together with Dicer-2, for efficient RNAi).

(Tamori et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106980

P{KK100519}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Stat92E^KK100519

Stat92E^RNAi

(Bhaskar et al., 2022)

Stat^RNAi

(Wang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

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