FlyBase Allele Report: Dmel\egr[KK103432]

General Information

Symbol

Dmel\egr^KK103432

Species

D. melanogaster

Name

FlyBase ID

FBal0232323

Feature type

allele

Associated gene

Dmel\egr

Associated Insertion(s)

Carried in Construct

P{KK103432}

Also Known As

egr-IR

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK103432}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK103432

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

modeled by dlg1^GD4689

(Parisi et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | larval stage, with Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

Phenotype Manifest In

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^Hml.Δ/egr^KK103432 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Scer\GAL4^sd-SG29.1/egr^KK103432 is an enhancer of neoplasia | larval stage phenotype of Scer\GAL4^sd-SG29.1, dlg1^GD4689

(Parisi et al., 2014)

NOT Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

egr^KK103432, Scer\GAL4^bbg-C96 is a suppressor of visible | adult stage phenotype of Mnat9^KK109382, Scer\GAL4^bbg-C96

(Mok and Choi, 2021)

egr^KK103432, Scer\GAL4^elav-C155 is a suppressor of increased cell death | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^elav-C155

(Wu et al., 2017)

egr^KK103432, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^elav-C155

(Wu et al., 2017)

egr^KK103432, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^elav-C155

(Wu et al., 2017)

Scer\GAL4^en.PU/egr^KK103432 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^en.PU/egr^KK103432 is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

NOT Suppressor of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-suppressor of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is a non-suppressor of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

egr^KK103432, Scer\GAL4^Antp-10 is a non-suppressor of increased cell number | third instar larval stage phenotype of ND-75^GD6309, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Hml.Δ/egr^KK103432 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Scer\GAL4^sd-SG29.1/egr^KK103432 is an enhancer of wing disc phenotype of Scer\GAL4^sd-SG29.1, dlg1^GD4689

(Parisi et al., 2014)

NOT Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

egr^KK103432, Scer\GAL4^bbg-C96 is a suppressor of wing phenotype of Mnat9^KK109382, Scer\GAL4^bbg-C96

(Mok and Choi, 2021)

egr^KK103432, Scer\GAL4^elav-C155 is a suppressor of adult brain phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^elav-C155

(Wu et al., 2017)

Scer\GAL4^en.PU/egr^KK103432 is a suppressor | partially of wing disc posterior compartment | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^en.PU/egr^KK103432 is a non-suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^en.PU/egr^KK103432 is a non-suppressor of hemocyte | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-suppressor of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is a non-suppressor of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

egr^KK103432, Scer\GAL4^Antp-10 is a non-suppressor of lamellocyte | third instar larval stage phenotype of ND-75^GD6309, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (together with Dicer-2, for efficient RNAi) leads to a significant increase in apoptosis in the posterior compartment of the third instar larval wing disc, which is suppressed by co-expressing egr^KK103432.

Expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (together with Dicer-2, for efficient RNAi) results in increased numbers of hemocytes on the surface of third instar larval wing discs, as compared to controls, which are not suppressed by co-expressing egr^KK103432.

(Liu et al., 2015)

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is virtually abrogated by the expression of egr^KK103432, alone or in combination with Ras85D^V12.UAS, under the control of Scer\GAL4^Hml.Δ or by the co-expression of Tl^UASp.Venus and egr^KK103432 under the control of Scer\GAL4^Cg.PA.

(Parisi et al., 2014)

Expression of egr^KK103432 does not suppress the increase in circulating lamellocytes seen when ND75^GD6309 is expressed under the control of Scer\GAL4^Antp-10.

(Sinenko et al., 2011)

Xenogenetic Interactions

Statement

Reference

Co-expression of egr^KK103432 partially suppresses the increased cell death in the brain, the climbing defects, and the shortened lifespan seen in Ecc15-infected flies expressing Hsap\APP^{Aβ42.Scer\UAS.cBa} under the control of Scer\GAL4^elav-C155.

(Wu et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108814

P{KK103432}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

egr^KK103432

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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