FlyBase Allele Report: Dmel\wg[KK108857]

General Information

Symbol

Dmel\wg^KK108857

Species

D. melanogaster

Name

FlyBase ID

FBal0235873

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

P{KK108857}

Also Known As

wg RNAi, UAS-Wg-RNAi, Wg-i

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108857}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108857

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinitis pigmentosa 4

modeled by ninaE^P37H.UAS

(Park et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

decreased size | adult stage, with Scer\GAL4^nub-AC-62

(Ewen-Campen et al., 2020)

visible | adult stage, with Scer\GAL4^nub-AC-62

(Ewen-Campen et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

larval ostial pore | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

synapse | adult stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

wing, with Scer\GAL4^nub-AC-62

(Ewen-Campen et al., 2020)

wing margin | absent, with Scer\GAL4^nub-AC-62

(Ewen-Campen et al., 2020)

Detailed Description

Statement

Reference

Expressing wg^KK108857 under the control of Scer\GAL4^Toll-6-D42 leads to third instar larval neuromuscular junctions showing significantly fewer synapses, as compared to controls.

(Portela et al., 2019)

Expression of wg^KK108857 under the Scer\GAL4^svp.PT driver in embryos results in ostia cell shape being rounder than wild-type.

(Trujillo et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

wg^KK108857/Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, p53^UAS.cUa

(Park et al., 2023)

Suppressor of

Statement

Reference

wg^KK108857/Scer\GAL4^unspecified is a suppressor | partially of visible | adult stage phenotype of ninaE^P37H.GMR

(Park et al., 2023)

wg^KK108857/Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | larval stage phenotype of Scer\GAL4^GMR.PU, ninaE^P37H.UAS

(Park et al., 2023)

wg^KK108857, Scer\GAL4^unspecified is a suppressor of visible | adult stage phenotype of Ire1^GD3071, Scer\GAL4^unspecified, ninaE^P37H.GMR

(Park et al., 2023)

wg^KK108857, Scer\GAL4^e22c is a suppressor of increased size | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^e22c

(Romão et al., 2021)

wg^KK108857, Scer\GAL4^ptc-559.1 is a suppressor | partially of hyperplasia phenotype of N^UAS.icd, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

NOT Suppressor of

Statement

Reference

wg^KK108857/Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, p53^UAS.cUa

(Park et al., 2023)

wg^KK108857, Scer\GAL4^ap-md544 is a non-suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

wg^KK108857, Scer\GAL4^repo is a non-suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

wg^KK108857, Scer\GAL4^repo is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Scer\GAL4^Su(H).GBE/wg^KK108857 is a non-suppressor of neoplasia phenotype of Sox21a⁶

(Zhai et al., 2015)

Other

Statement

Reference

Scer\GAL4^nub-AC-62, Wnt4^JF03378, wg^KK108857 has visible | adult stage phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt4^JF03378, wg^KK108857 has decreased size | adult stage phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt6^GD11490, wg^KK108857 has visible | adult stage phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt6^GD11490, wg^KK108857 has decreased size | adult stage phenotype

(Ewen-Campen et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

wg^KK108857/Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PU, p53^UAS.cUa

(Park et al., 2023)

Suppressor of

Statement

Reference

wg^KK108857/Scer\GAL4^unspecified is a suppressor | partially of eye phenotype of ninaE^G69D

(Park et al., 2023)

wg^KK108857/Scer\GAL4^unspecified is a suppressor | partially of ommatidium | adult stage phenotype of ninaE^G69D

(Park et al., 2023)

wg^KK108857/Scer\GAL4^unspecified is a suppressor | partially of eye phenotype of ninaE^P37H.GMR

(Park et al., 2023)

wg^KK108857/Scer\GAL4^GMR.PU is a suppressor | partially of eye disc | larval stage phenotype of Scer\GAL4^GMR.PU, ninaE^P37H.UAS

(Park et al., 2023)

wg^KK108857, Scer\GAL4^unspecified is a suppressor of eye phenotype of Ire1^GD3071, Scer\GAL4^unspecified, ninaE^P37H.GMR

(Park et al., 2023)

wg^KK108857, Scer\GAL4^e22c is a suppressor of wing disc | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^e22c

(Romão et al., 2021)

NOT Suppressor of

Statement

Reference

wg^KK108857/Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, p53^UAS.cUa

(Park et al., 2023)

wg^KK108857, Scer\GAL4^repo is a non-suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

wg^KK108857, Scer\GAL4^repo is a non-suppressor of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

wg^KK108857, Scer\GAL4^repo is a non-suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Scer\GAL4^Su(H).GBE/wg^KK108857 is a non-suppressor of adult anterior midgut epithelium phenotype of Sox21a⁶

(Zhai et al., 2015)

Other

Statement

Reference

Scer\GAL4^nub-AC-62, Wnt4^JF03378, wg^KK108857 has wing phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt4^JF03378, wg^KK108857 has wing margin | absent phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt6^GD11490, wg^KK108857 has wing phenotype

(Ewen-Campen et al., 2020)

Scer\GAL4^nub-AC-62, Wnt6^GD11490, wg^KK108857 has wing margin | absent phenotype

(Ewen-Campen et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of wg^KK108857 in enteroblasts under the control of Scer\GAL4^Su(H).GBE does not reduce tumor formation in the anterior midgut of Sox21a⁶ mutant flies.

(Zhai et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104579

P{KK108857}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wg^KK108857

wg^dsRNA

(Luo et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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