FlyBase Allele Report: Dmel\Arc1[E8]

General Information

Symbol

Dmel\Arc1^E8

Species

D. melanogaster

Name

FlyBase ID

FBal0344117

Feature type

allele

Associated gene

Dmel\Arc1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Ashley et al., 2018)

Mutagen

CRISPR/Cas9

(Ashley et al., 2018)

Progenitor genotype

Cytology

Description

Deletion within Arc1.

(Ashley et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:14,358,617..14,360,167 [-]

Comment:

Estimate of endpoints of CRISPR deletion within Arc1 from author.

(Thomson, 2019.1.16)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Keith et al., 2021)

abnormal developmental rate (with Arc1^esm113)

(Keith et al., 2021)

abnormal starvation stress response | adult stage

(Keith et al., 2021)

decreased body size | P-stage

(Keith et al., 2021)

increased cell number | adult stage

(Keith et al., 2021)

Phenotype Manifest In

embryonic/larval fat body | larval stage

(Keith et al., 2021)

lipid droplet | larval stage

(Keith et al., 2021)

wing cell | increased number

(Keith et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Arc1^E8 is partially rescued by Arc1^UAS.cMb/Scer\GAL4^arm.PS

(Keith et al., 2021)

Arc1^E8 is partially rescued by Arc1^UAS.cMb/Scer\GAL4^GMR96A08

(Keith et al., 2021)

Arc1^E8 is partially rescued by Arc1^UAS.cMb/Scer\GAL4^phtm.PO

(Keith et al., 2021)

Not rescued by

Arc1^E8 is not rescued by Scer\GAL4^drm.7.1/Arc1^UAS.cMb

(Keith et al., 2021)

Arc1^E8 is not rescued by Arc1^UAS.cMb/Scer\GAL4^r4

(Keith et al., 2021)

Arc1^E8 is not rescued by Arc1^UAS.cMb/Scer\GAL4^C57

(Keith et al., 2021)

Arc1^E8 is not rescued by Arc1^UAS.cMb/Scer\GAL4^Appl.G1a

(Keith et al., 2021)

Arc1^E8 is not rescued by Scer\GAL4^mex1.PU/Arc1^UAS.cMb

(Keith et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Arc1^E8

(Gordon et al., 2023, Keith et al., 2021)

darc1^E8

(Ashley et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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