FB2025_05 , released December 11, 2025
Allele: Dmel\AktΔPH.UAS.Tag:Myr(Unk)
Open Close
General Information
Symbol
Dmel\AktΔPH.UAS.Tag:Myr(Unk)
Species
D. melanogaster
Name
FlyBase ID
FBal0345170
Feature type
allele
Associated gene
Dmel\Akt
Associated Insertion(s)
Carried in Construct
P{UAS-myr-Akt.ΔPH}
Also Known As
UAS-myr-Akt, UAS-myrAKT
Key Links
Transgenic product class
inframe_deletion
(Zheng and Popodi, 2019.1.16)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zheng and Popodi, 2019.1.16)
Mutagen
in vitro construct
(Zheng and Popodi, 2019.1.16)
Progenitor genotype
Carried in construct
P{UAS-myr-Akt.ΔPH}
Cytology
Description

UAS regulatory sequences drive expression of an N-terminally deleted form of Akt1; the first 341 bp of the coding sequence of Akt1-RA are missing, resulting in a deletion of 75% of the PH domain in the encoded protein. The coding sequence is tagged with a myristoylation signal.

(Zheng and Popodi, 2019.1.16)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Akt
Tagged with
Tag:Myr(Unk)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  carcinoma
      CEA
      (Bhattacharya et al., 2024)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AktΔPH.UAS.Tag:Myr(Unk) under the control of Scer\GAL4en-e16E leads to an increase in cell death in posterior compartment of third instar larval wing discs.

      (Sun et al., 2020)

      Expression of Akt1ΔPH.UAS.Tag:Myr(Unk) under the control of Scer\GAL4Tub.PU in midgut MARCM clones leads to a significant decrease in cell number but an increase in cell size when compared to control adults.

      (Mattila et al., 2018)

      Expression of Akt1ΔPH.UAS.Tag:Myr(Unk) under the control of Scer\GAL4nSyb.PS does not lead to any synaptic overgrowth at neuromuscular junction (assessed by number of boutons and NMJ length) nor any significant changes in crawling velocity in third instar larvae.

      (West et al., 2018)

      Expression of Akt1ΔPH.UAS.Tag:Myr(Unk) under the control of Scer\GAL4tim.UAS, dramatically increases sensitivity to oxidative stress. These flies die within 2 days of being challenged with 1mM paraquat. When treated with 0.05-0.1mM paraquat they survive up to 6 days, with the majority showing arrhythmic locomotor behavior.

      Expression of Akt1ΔPH.UAS.Tag:Myr(Unk) in the fat body, under the control of Scer\GAL4Lk6-DJ634, increases sensitivity of behavioral rhythms to paraquat.

      (Zheng et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Akt1ΔPH.UAS.Tag:Myr(Unk)
      AktΔPH.UAS.Tag:Myr(Unk)
      Name Synonyms
      Secondary FlyBase IDs
        References (19)