FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\ZNF746UAS.cDa
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General Information
Symbol
Hsap\ZNF746UAS.cDa
Species
H. sapiens
Name
UAS construct a of Dawson
FlyBase ID
FBal0357243
Feature type
allele
Associated gene
Hsap\ZNF746
Associated Insertion(s)
Carried in Construct
P{UAS-hZNF746.D}
Key Links
Transgenic product class
cDNA
(Dawson, 2019.12.17)
wild_type
(Dawson, 2019.12.17)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dawson, 2019.12.17)
wild_type
(Dawson, 2019.12.17)
Mutagen
in vitro construct
(Dawson, 2019.12.17)
Progenitor genotype
Carried in construct
P{UAS-hZNF746.D}
Cytology
Description

UASt regulates expression of a Hsap\ZNF746 cDNA.

(Dawson, 2019.12.17)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ZNF746
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Hsap\ZNF746UAS.cDa under the control of Scer\GAL4Act5C.PI show a progressive decline in climbing activity, and a progressive decrease in DA neuron number (PPL1, PPL2, PPM1/2 and PPM3 clusters). Similarly, expression under the control of Scer\GAL4ple.PF leads to a progressive decline in climbing activity, and a progressive decrease in DA neuron number (PPL1, PPL2, PPM1/2 and PPM3 clusters); DA neurons also show decreased abundance of mitochondria.

      (Pirooznia et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      Hsap\ZNF746UAS.cDa, Scer\GAL4Act5C.PI has increased mortality during development phenotype, suppressible | partially by Hsap\PRKNWT.UAS, Scer\GAL4Act5C.PI

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4Act5C.PI has increased mortality during development phenotype, suppressible | partially by parkUAS.cGa, Scer\GAL4Act5C.PI

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by parkUAS.cGa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has decreased cell number | adult stage | progressive phenotype, suppressible by srlUAS.cRa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Pink1UAS.cCa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by srlUAS.cRa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Pink1UAS.cCa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by srlUAS.cRa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by parkUAS.cGa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)

      Hsap\ZNF746UAS.cDa, Scer\GAL4ple.PF has decreased cell number | adult stage phenotype, suppressible by Pink1UAS.cCa, Scer\GAL4ple.PF

      (Pirooznia et al., 2020)
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\ZNF746UAS.cDa
      Name Synonyms
      UAS construct a of Dawson
      Secondary FlyBase IDs
        References (3)