FlyBase Allele Report: Dmel\Ras85D[V12.cZa.UASp]

General Information

Symbol

Dmel\Ras85D^V12.cZa.UASp

Species

D. melanogaster

Name

FlyBase ID

FBal0405030

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{UASp-Ras85D.V12.Z}

Key Links

Transgenic product class

missense_variant

(Zhang et al., 2024)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Zhang et al., 2024)

Mutagen

in vitro construct

(Zhang et al., 2024)

Progenitor genotype

Carried in construct

P{UASp-Ras85D.V12.Z}

Cytology

Description

UASp regulatory sequences drive expression of mutant (V12) Ras85D.

(Zhang et al., 2024)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile, with Scer\GAL4^VP16.bam

(Zhang et al., 2024)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

increased occurrence of cell division | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

increased size | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Phenotype Manifest In

egg chamber | increased number, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

female germline stem cell, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

germarium, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

nurse cell, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

spectrosome | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has increased size | oogenesis phenotype, enhanceable by bam[+]/bam^Δ86

(Zhang et al., 2024)

Suppressed by

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has increased size | oogenesis phenotype, suppressible by Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has increased size | oogenesis phenotype, suppressible by rl^HMS00173, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Other

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has increased occurrence of cell division | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has abnormal cell number | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has decreased cell size | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has increased size | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bgcn^MI06696/bgcn¹ has increased size | oogenesis phenotype

(Zhang et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has spectrosome | oogenesis phenotype, enhanceable by bam[+]/bam^Δ86

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has germarium phenotype, enhanceable by bam[+]/bam^Δ86

(Zhang et al., 2024)

Suppressed by

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has germarium phenotype, suppressible by Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has germarium phenotype, suppressible by rl^HMS00173, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has spectrosome | oogenesis phenotype, suppressible | partially by Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has spectrosome | oogenesis phenotype, suppressible | partially by rl^HMS00173, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has egg chamber | increased number phenotype, suppressible | partially by Cdk1[+]/Cdk1^B47

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has egg chamber | increased number phenotype, suppressible | partially by CycA^C8LR1/CycA[+]

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has egg chamber | increased number phenotype, suppressible | partially by Dronc^HMS00758, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR} has egg chamber | increased number phenotype, suppressible | partially by Dredd^HMS00063, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Other

Statement

Reference

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^UASp.GFP has egg chamber | increased number phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has ovary phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has female germline cell phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bgcn^MI06696/bgcn¹ has ovary phenotype

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ras85D^V12.cZa.UASp is rescued by Scer\GAL4^{VP16.nanos.UTR}/Ras85D^{TH201501177.S}

(Zhang et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ras85D^V12.cZa.UASp

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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