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FB2026_01
,
released March 12, 2026
P6
Please see the JBrowse view of Dmel\Fbp2 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Gene model reviewed during 5.56
0.975 (sequence analysis)
0.9 (northern blot)
256 (aa); 29 (kD predicted)
29 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fbp2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
As deduced by in vitro translation experiments, Fbp2 is expressed at 18-30 hr after the second larval molt. Transcript levels remained high at the prepupal stage. The transcript levels did not increase in response to ecdysone.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Fbp2 in JBrowse2-35
2-30.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
The Dpse\Fbp2 gene has been cloned and sequenced, and compared with the Fbp2 gene of D.melanogaster.
Reduced Fbp2 RNA levels in br mutants can be restored to wild type by transgenes bearing the Z1, Z2, Z3 or Z4 isoforms of BRC products.
Ecdysteroid-regulated gene.
The steroid hormone 20-hydroxyecdysone can regulate RNA levels of a single gene both positively and negatively depending on hormone concentration. br can modify the direction of the gene's response to a hormone signal.
Fbp2 has been cloned and sequenced.
Gene detected in the larval fat body of D.melanogaster. Function of the protein product uncertain (Deutch, Laval, Lepesant, Maschat, Pourrain and Rat, 1989).
