yemalpha, yem-alpha, yem-α, yemα, yemanuclein α
Please see the JBrowse view of Dmel\yem for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Stop-codon suppression (UGA) postulated; FBrf0216884; protein extension supported (FBrf0223513).
Gene model reviewed during 5.44
Gene model reviewed during 5.47
4.5 (northern blot)
None of the polypeptides share 100% sequence identity.
The N-terminus is blocked.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yem using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
During oogenesis, yemα transcript is first detected in germarium region 2, in the presumptive oocyte. Before stage 8, expression is detected in the posterior pole of the oocyte, while expression is detected in the anterior pole at stages S8-S10A. From stage S10B on, expression is uniform in the oocyte.
The 4.5 kb yemα transcript is maternal. It is abundant in the ovary and in pre-gastrulation embryos.
The 4.5 kb yemα transcript localizes to the periphery of the oocyte nucleus at stage S7 of oogenesis. By stage S8, when the nucleus starts migrating dorsally, transcripts are localized anteriorly. The anterior localization is maintained until at least stage S10A of oogenesis. At stage S10B, localization becomes uniform. The transcripts are localized uniformly in the preblastoderm embryo. Transcript levels are lower in the syncytial blastoderm embryo, barely detectable during gastrulation, and not detected after gastrulation.
JBrowse - Visual display of RNA-Seq signals
View Dmel\yem in JBrowse



3-97
3-94.8
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
yemα is essential for the assembly of His3.3-containing nucleosomes in the male pronucleus at fertilisation.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
The structure and role of the yema gene cluster has been determined by a study of the organization of the yema transcription units and an extensive survey of their temporal and spatial expression patterns. Results demonstrate that yema transcripts are mainly expressed in tissues that contain actively dividing and differentiating cells, suggesting that the yema gene cluster contains genes whose expression is related to cell proliferation and/or cell differentiation.
The "yema" gene cluster has been identified, and the spatial and temporal expression of the transcripts encoded by it have been characterised.
One of a cluster of maternal effect genes active in oogenesis that have been isolated through their messenger RNAs and located by molecular methods at the distal end of 3R.
Source for merge of: yemα CG14513
Source for identity of: yem yemα
The gene is called "yemanuclein-alpha" because it is the first gene of the yema cluster to be analyzed and it encodes an oocyte specific nuclear protein; "Yema" means "mother" in kabyle (the discoverer's mother tongue).