FlyBase Gene Report: Dmel\BRWD3

General Information

Symbol

Dmel\BRWD3

Species

D. melanogaster

Name

BRWD3

Annotation Symbol

CG31132

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011785

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

BRWD3 (BRWD3) encodes a member of the Bromodomain and WD repeat_containing protein (BRWD) family. It regulates ecdysone and JAK-STAT signaling pathways and contributes to eye development, cell death and phagocytosis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

dBRWD3, l(3)05842, ramshackle, psg13

Key Links

Genomic Location

Cytogenetic map

95F12-95F13

Sequence location

3R:24,319,000..24,328,619 [+]

Recombination map

3-84

RefSeq locus

NT_033777 REGION:24319000..24328619

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in autophagic cell death

inferred from mutant phenotype

(Ihry and Bashirullah, 2014)

involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Ihry and Bashirullah, 2014)

involved_in positive regulation of receptor signaling pathway via JAK-STAT

inferred from genetic interaction with FLYBASE:upd1; FB:FBgn0004956

(Muller et al., 2005)

involved_in regulation of gene expression

inferred from mutant phenotype

(Chen et al., 2015)

involved_in regulation of photoreceptor cell differentiation

inferred from mutant phenotype

(Chen et al., 2015)

involved_in response to ecdysone

inferred from mutant phenotype

(Ihry and Bashirullah, 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000417686

(GO Reference Genome Project, 2011-)

involved_in regulation of cell shape

inferred from biological aspect of ancestor with PANTHER:PTN000417686

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000417686

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000417686

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -: Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\BRWD3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VC96)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Apparent introns not annotated: probable artifacts due to repetitive sequence.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

BRWD3-RA

FBtr0084604

NM_170139

7244

2232

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

BRWD3-PA

FBpp0083988

248.7

2232

6.58

Q9VC96

NP_732982

AAF56278

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\BRWD3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

BRWD3_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression

dissected tissue

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval salivary gland

Comment: from -12 hr APF

(Ihry and Bashirullah, 2014)

prepupal stage P1 -- P4

embryonic/larval salivary gland

Comment: peak at P4

(Ihry and Bashirullah, 2014)

Additional Descriptive Data

Expression increases after the prepupal (+10 hr APF) ecdysone pulse.

(Ihry and Bashirullah, 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\BRWD3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\BRWD3

View exonic expression by tissue for Dmel\BRWD3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42898/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011785

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011785

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011785

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31132

Flygut - An atlas of the Drosophila adult midgut

FBgn0011785

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of BRWD3

Transgenic constructs containing regulatory region of BRWD3

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)BSC638

(Ihry and Bashirullah, 2014)

Df(3R)crb87-4

(Muller, 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3R)crb87-5

(Muller, 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3R)ED6187

(Sapiro et al., 2013)

Df(3R)Exel6199

(Ihry and Bashirullah, 2014, Ryder, 2004.4.26)

Df(3R)Exel8178

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | somatic clone

BRWD3^s5349

lethal

BRWD3^psg13

lethal (with BRWD3^ram1)

BRWD3^s5349

lethal (with BRWD3^s5349)

BRWD3^ram1

lethal (with Df(3R)BSC638)

BRWD3^{CR00322-TG4.0}

lethal | pupal stage

BRWD3⁰⁶⁶⁵⁶

lethal | recessive

lethal | second instar larval stage

BRWD3^s5349

lethal | second instar larval stage (with Df(3R)crb87-5)

BRWD3^s5349

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

BRWD3^GD10174

lethal - all die before end of pupal stage | recessive

BRWD3^PX2

lethal - all die before end of second instar larval stage

BRWD3^ram1

partially lethal - majority die | first instar larval stage

BRWD3^s5349

partially lethal - majority die | first instar larval stage (with Df(3R)crb87-5)

BRWD3^s5349

partially lethal - majority die | third instar larval stage

BRWD3⁰⁶⁶⁵⁶

viable (with BRWD3⁰⁶⁶⁵⁶)

BRWD3^GS3279

viable (with BRWD3^GS3279)

BRWD3⁰⁶⁶⁵⁶

Other Phenotypes

Allele

abnormal neuroanatomy, with Scer\GAL4^ppk.PU

BRWD3^GD10174

abnormal neuroanatomy | somatic clone

BRWD3^s5349

some die during pupal stage, with Scer\GAL4^pnr-MD237

BRWD3^GD10174

some die during second instar larval stage

BRWD3^ram1

visible, with Scer\GAL4^ey-OK107

BRWD3^GD10174

visible | somatic clone

Phenotype manifest in

Allele

actin filament

BRWD3^s5349

arista, with Scer\GAL4^dpp.PU

BRWD3^GD10174

cone cell | somatic clone

BRWD3^s5349

embryonic/larval midgut | third instar larval stage

BRWD3^psg13

embryonic/larval salivary gland | prepupal stage

BRWD3^psg13

eye, with Scer\GAL4^ey-OK107

BRWD3^GD10174

eye | somatic clone

eye disc & actin cytoskeleton | somatic clone

BRWD3^PX2

eye disc & nucleus | somatic clone

BRWD3^PX2

larval multidendritic class IV neuron, with Scer\GAL4^ppk.PU

BRWD3^GD10174

nucleus

BRWD3^s5349

photoreceptor | somatic clone

BRWD3^s5349

rhabdomere & eye disc & pupa

BRWD3^PX3

wing vein | ectopic

BRWD3^Δ10

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\BRWD3

12 of 14

Yes

Hsap\PHIP

12 of 14

Yes

Hsap\BRWD1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Brwd3

11 of 14

Yes

Rnor\Phip

11 of 14

Yes

Rnor\Brwd1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Brwd3

12 of 14

Yes

Mmus\Phip

12 of 14

Yes

Mmus\Brwd1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\brwd1

9 of 13

Yes

Xtro\brwd3

9 of 13

Yes

Xtro\atp23

5 of 13

Xtro\phip

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\wdr48

1 of 13

Danio rerio (Zebrafish) (10)

Drer\phip

12 of 14

Yes

Drer\brwd3

11 of 14

Yes

Drer\brwd1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\bet-1

1 of 14

Yes

Cele\bet-2

1 of 14

Yes

Cele\chaf-2

1 of 14

Yes

Cele\dyci-1

1 of 14

Yes

Cele\elpc-2

1 of 14

Yes

Cele\F13C5.2

1 of 14

Yes

Cele\hira-1

1 of 14

Yes

Cele\lex-1

1 of 14

Yes

Cele\nmtn-1

1 of 14

Yes

Cele\pbrm-1

1 of 14

Yes

Cele\taf-1

1 of 14

Yes

Cele\W07E6.2

1 of 14

Yes

Cele\wdr-12

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP002030

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\AT2G47410

10 of 13

Yes

Atha\AT5G49430

10 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\BDF1

1 of 13

Yes

Scer\BDF2

1 of 13

Yes

Scer\CAC2

1 of 13

Yes

Scer\ELP2

1 of 13

Yes

Scer\HIR1

1 of 13

Yes

Scer\LAF1

1 of 13

Yes

Scer\RSA4

1 of 13

Yes

Scer\RSC4

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\bdf1

1 of 12

Yes

Spom\elp2

1 of 12

Yes

Spom\rsc4

1 of 12

Yes

Spom\SPAC631.02

1 of 12

Yes

Spom\SPCC18.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:BRWD3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (24)

bon

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

intellectual disability, BRWD-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

BRWD3; bromodomain and WD repeat domain containing 3

model of non-syndromic X-linked intellectual disability 93

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BRWD3; bromodomain and WD repeat domain containing 3

12 of 14

300553

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 93; XLID93

non-syndromic X-linked intellectual disability 93

PHIP; PHIP subunit of CUL4-Ring ligase complex

12 of 14

612870

CHUNG-JANSEN SYNDROME; CHUJANS

BRWD1; bromodomain and WD repeat domain containing 1

10 of 14

617824

CILIARY DYSKINESIA, PRIMARY, 51; CILD51

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

BRWD3 - CkIIα

experimental knowledge based

(Guruharsha et al., 2011)

BRWD3 - CkIIβ

experimental knowledge based

(Guruharsha et al., 2011)

BRWD3 - Hira

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2015)

BRWD3 - His3

pull down, molecular weight estimation by staining

(Morgan et al., 2017)

BRWD3 - cry

enzymatic study, anti tag western blot, pull down, two hybrid

(Ozturk et al., 2013)

BRWD3 - jet

pull down, anti tag western blot

(Ozturk et al., 2013)

BRWD3 - pic

experimental knowledge based

(Guruharsha et al., 2011)

BRWD3 - yem

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

BRWD3

suppressible

Hira

(Chen et al., 2015)

BRWD3

suppressible

His3.3B

(Chen et al., 2015)

BRWD3

suppressible

XNP

(Chen et al., 2015)

BRWD3

suppressible

yem

(Chen et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

BRWD3

(D'Costa et al., 2006)

hop

suppressible

BRWD3

(Muller et al., 2005)

upd1

suppressible

BRWD3

(Muller et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67826

DroID - A comprehensive database of gene and protein interactions.

FBgn0011785

MIST (protein-protein) - An integrated Molecular Interaction Database

42898

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VC96

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-84

Cytogenetic map

95F12-95F13

Sequence location

3R:24,319,000..24,328,619 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95F12-95F13

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95F11-95F12

(determined by in situ hybridisation)

(Spradling et al., 1999)

95F11-95F12

95F14--15

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-84

(FlyBase, 2016)

3-79.8

(Sapiro et al., 2013)

3-83.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

35560

w^*; BRWD3^PX1/TM3, Ser¹

35824

w^*; P{neoFRT}82B P{lacW}BRWD3^s5349/TM2

77079

y¹ sc^* v¹ sev²¹; P{TKO.GS00870}attP40

78178

y¹ sc^* v¹ sev²¹; P{TOE.GS01336}attP40

33421

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00304}attP2

Kyoto

113677

w^*; P{GawB}BRWD3^NP5316 / TM6, P{UAS-lacZ.UW23-1}UW23-1

105029

y^* w^*; P{GawB}BRWD3^NP5467 / TM6, P{UAS-lacZ.UW23-1}UW23-1

200601

y¹ w^67c23; P{GSV1}BRWD3^GS3279/TM3, Sb¹ Ser¹

NIG-Fly

HMS00304

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00304}attP2

VDRC

v110808

P{KK101405}VIE-260B

v40209

w¹¹¹⁸; P{GD10174}v40209

v318233

PBac{fTRG00871.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD40380

Other clones

DPiM_LD40380

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011785

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011785

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG6400 CG18670

(Muller, 2005, FlyBase, 1996-)

Source for merge of: CG31132 anon-WO0118547.520 anon-WO0118547.620

(FlyBase, 1996-)

Additional comments

Annotations CG18670, CG6400 merged as CG31132 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG6400 CG18670 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Source for merge of CG31132 anon-WO0118547.520 anon-WO0118547.620 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: BRWD3 CG31132

(Muller, 2005, Muller et al., 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

Brwd3

(Mbodj et al., 2013, Ozturk et al., 2013)

CG18670

(Mount, 2001.8.14)

CG31132

(Hosono et al., 2015, Meadows, 2014.12.12, Ibrahim et al., 2013, Ozturk et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Stroschein-Stevenson et al., 2006, Muller, 2005, Muller et al., 2005, Davies et al., 2001, FlyBase, 1996-)

CG6400

(Li et al., 2007, Stathopoulos et al., 2002)

anon-WO0118547.520

anon-WO0118547.620

brwd3

(Abdalla et al., 2022, Ihry and Bashirullah, 2014)

dBRWD3

(Morgan et al., 2017, Shih et al., 2016, Chen et al., 2015, Valanne, 2014, Muller, 2005, Muller et al., 2005, Muller et al., 2005)

l(3)05842

(D'Costa et al., 2006, Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)s5349

psg13

(Ihry and Bashirullah, 2014, Sapiro et al., 2013)

ram

(D'Costa et al., 2006)

Name Synonyms

BRWD3

(Cammarato et al., 2011)

Ramshackle

(Damulewicz and Mazzotta, 2020)

lethal (3) 05842

ramshackle

(Michael et al., 2017, Ozturk et al., 2013, D'Costa et al., 2006)

Secondary FlyBase IDs

FBgn0011039
FBgn0039181
FBgn0040598
FBgn0051132
FBgn0061821
FBgn0061922

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42898

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VC96

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VC96

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42898/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011785

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011785

FlyMine - An integrated database for Drosophila genomics

FBgn0011785

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31132

MARRVEL_MODEL - MARRVEL (model organism gene)

42898

Linkouts

BioGRID - A database of protein and genetic interactions.

67826

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011785

DroID - A comprehensive database of gene and protein interactions.

FBgn0011785

DRSC - Results frm RNAi screens

FBgn0011785

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

BRWD3_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011785

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011785

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31132

Flygut - An atlas of the Drosophila adult midgut

FBgn0011785

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011785

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004357

MIST (protein-protein) - An integrated Molecular Interaction Database

42898

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VC96

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

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