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FB2026_01
,
released March 12, 2026
guf, gut feeling, AZ, gutfeeling
modifies the activity of Ornithine decarboxylase - regulates the nuclear entry and overall levels of Sex-lethal in early germ cells.
Please see the JBrowse view of Dmel\Oda for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.39
Translational frameshifting postulated (FBrf0100578 and GB:AF038597): +1 frameshift reflected in aa sequence of predicted polypeptides.
Gene model reviewed during 5.56
+1 frameshift corresponds to genomic location 2R(r6):12,168,046.
1.8 (northern blot)
2.1 (northern blot)
None of the polypeptides share 100% sequence identity.
254 (aa); 28 (kD predicted)
186 (aa); 21 (kD predicted)
Interacts with ODC1 and thereby sterically blocks ODC homodimerization.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Oda using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
guf transcripts are detected in embryonic RNA.
guf transcripts are detected throughout development on northern blots. Low levels of uniformly distributed guf RNA are detected in precellularized embryos by in situ hybridization. During gastrulation and germ band extension, transcripts are most prominent in the mesoderm and invaginating posterior midgut. In stage 11, expression is observed in fat body precursors, Malpighian tubule rudiments, and the foregut. At late stage 12, guf is expressed all over the embryo at low levels including the subectodermal layer that contains most of the PNS cells. Transcripts are first detected in developing body wall muscles in stage 14. Expression in the body wall muscles, fat body, and midgut is maintained throughout the rest of embryonic development.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Oda in JBrowse2-66
2-67.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Oda encodes an antizyme that is apparently regulated by translational frameshifting.
The mutant phenotypes of the "l(2)k09540" and "l(2)k11803" lines were previously attributed to an effect on the Oda gene (FBrf0089808), however, evidence in FBrf0149027 shows that the mutant phenotype of these lines (and other P-element insertion lines located within an intron of Oda) is actually due to an effect on SmD3 (a gene nested in an intron of Oda) and not on Oda.
The complementation group represented by "l(2)k11803", "l(2)k09540" and "l(2)k09512" is named "gutfeeling" because all the P{lacW} insertion mutants confer strong Ecol\lacZ expression in the gut and affect sensory organ development. FlyBase curator comment: the mutant phenotype of "l(2)k11803", "l(2)k09540" and "l(2)k09512" is attributed to an effect on the Oda gene in FBrf0089808 and the Oda gene is shown to be expressed in the gut in FBrf0089808. However, FBrf0149027 shows that the mutant phenotype of "l(2)k11803", "l(2)k09540" and "l(2)k09512" is actually due to an effect on SmD3 (a gene nested in an intron of Oda) and not on Oda.
