FlyBase Gene Report: Dmel\Drip

General Information

Symbol

Dmel\Drip

Species

D. melanogaster

Name

Drip

Annotation Symbol

CG9023

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015872

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Drip (Drip) encodes a protein that belongs to the MIP/aquaporin family involved in the transport of water across the cell membrane. In addition to its cellular roles, it has been implicated in regulating aspects of reproduction and aging. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

aquaporin

Key Links

Genomic Location

Cytogenetic map

47F11-47F11

Sequence location

2R:11,411,203..11,429,645 [-]

Recombination map

2-64

RefSeq locus

NT_033778 REGION:11411203..11429645

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables water channel activity

inferred from mutant phenotype

(Cabrero et al., 2020)

inferred from direct assay

(Kaufmann et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables channel activity

inferred from electronic annotation with InterPro:IPR000425

(InterPro Project Members, 2004-)

enables water channel activity

inferred from sequence or structural similarity with UniProtKB:P55088

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN007668488

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in multicellular organismal-level water homeostasis

inferred from expression pattern

(Kaufmann et al., 2005)

involved_in renal water homeostasis

inferred from expression pattern

(Kaufmann et al., 2005)

involved_in transmembrane transport

inferred from direct assay

(Kaufmann et al., 2005)

involved_in water transport

inferred from mutant phenotype

(Cabrero et al., 2020)

inferred from direct assay

(Kaufmann et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR000425

(InterPro Project Members, 2004-)

involved_in water transport

inferred from biological aspect of ancestor with PANTHER:PTN007668488

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Cabrero et al., 2020)

located_in basolateral plasma membrane

inferred from direct assay

(Cabrero et al., 2020)

located_in membrane

inferred from direct assay

(Kaufmann et al., 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in apical plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN004504946

(GO Reference Genome Project, 2011-)

is_active_in basolateral plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN004504946

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR000425

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002709492

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

AQUAPORINS

Protein Family (UniProt)

Belongs to the MIP/aquaporin (TC 1.A.8) family. (Q9V5Z7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

AQUAPORINS -: Aquaporins (AQPs) are integral membrane proteins with a central pore formed form two highly conserved hydrophobic regions, NPA boxes, which contain the signature Asp-Pro-Ala motif. They selectively allow the transfer of water across the membranes. (Adapted from PMID:22542572).

Protein Function (UniProtKB)

Forms a water-specific channel.

(UniProt, Q9V5Z7)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Drip for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V5Z7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Drip-RA

FBtr0088141

NM_165833

1745

245

Drip-RB

FBtr0088142

NM_078973

1444

245

Drip-RC

FBtr0331387

NM_001273961

1514

243

Drip-RD

FBtr0331388

NM_001273962

1288

242

Drip-RE

FBtr0331389

NM_001273963

1180

239

Drip-RF

FBtr0331390

NM_001273964

1529

278

Drip-RG

FBtr0339488

NM_001299387

1351

233

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Drip-PA

FBpp0087240

25.6

245

6.91

FBpp0087241

25.6

245

6.91

FBpp0303805

25.4

243

6.91

FBpp0303806

25.2

242

6.91

FBpp0303807

24.9

239

7.45

FBpp0303808

29.3

278

8.28

FBpp0308570

24.1

233

8.33

A0A0B4LG55

NP_001286316

AHN56114

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

245 aa isoforms: Drip-PA, Drip-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, Q9V5Z7)

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

(UniProt, Q9V5Z7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drip using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.14

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

organism | ubiquitous

(Kaufmann et al., 2005)

embryonic stage 8 -- 12

embryonic/larval gut

(Kaufmann et al., 2005)

embryonic stage 14

embryonic/larval gut | restricted

(Kaufmann et al., 2005)

embryonic/larval pharynx

(Kaufmann et al., 2005)

embryonic stage 17

posterior spiracle primordium

(Kaufmann et al., 2005)

adult stage

adult Malpighian tubule Type II cell

(Denholm et al., 2013)

Additional Descriptive Data

At embryonic stage 14, Drip expression demarcates the foregut-midgut border, where the proventriculus will form, and the midgut-hindgut border, where the Malpighian tubules will connect.

(Kaufmann et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

Malpighian tubule Type II cell

(Tapadia and Gautam, 2011)

adult stage

adult Malpighian tubule stellate cell of main segment

• apical plasma membrane

(Cabrero et al., 2020)

protocerebrum | dorso-lateral | posterior

(Bergland et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Drip protein is localized to the apical plasma membrane of stellate cells, facing the lumen of the Malpighian tubule. Prip protein is localized opposite, on the basolateral plasma membrane, in contact with the outside of the Malpighian tubule (hemolymph).

(Cabrero et al., 2020)

Drip protein is seen in about 12 neurons located in the dorsolateral posterior compartments of the protocerebrum.

(Bergland et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Cabrero et al., 2020)

located_in basolateral plasma membrane

inferred from direct assay

(Cabrero et al., 2020)

located_in membrane

inferred from direct assay

(Kaufmann et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Drip in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Drip

View exonic expression by tissue for Dmel\Drip

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36236/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015872

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015872

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015872

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0015872

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Drip

Transgenic constructs containing regulatory region of Drip

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Drip^GD1936

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Drip^GD1936

viable

Drip^c05976

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Scer\GAL4^tin.CΔ4

Drip^GD1936

Sterility

Allele

fertile

Drip^c05976

Other Phenotypes

Allele

abnormal stress response | adult stage | female, with Scer\GAL4^VT040177

Drip^NIG.9023R

decreased fecundity | female, with Scer\GAL4^Crz.PC

Drip^KK107343

decreased fecundity | female, with Scer\GAL4^elav-C155

Drip^KK107343

decreased fecundity | female, with Scer\GAL4^αTub84B.PL

Drip^KK107343

Phenotype manifest in

Allele

adult Malpighian tubule, with Scer\GAL4^tsh-c724

Drip^NIG.9023R

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\AQP2

12 of 14

Yes

Hsap\AQP4

12 of 14

Yes

Hsap\AQP1

11 of 14

Yes

Hsap\AQP5

11 of 14

Yes

Hsap\MIP

9 of 14

Yes

Hsap\AQP6

7 of 14

Yes

Hsap\AQP8

7 of 14

Yes

5 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

Yes

Hsap\AQP11

1 of 14

Hsap\AQP12A

1 of 14

Hsap\AQP12B

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Aqp4

12 of 14

Yes

Rnor\Aqp1

11 of 14

Yes

Rnor\Aqp2

11 of 14

Yes

Rnor\Aqp5

10 of 14

Yes

Rnor\Mip

10 of 14

Yes

Rnor\Aqp6

8 of 14

Yes

Rnor\Aqp8

7 of 14

Yes

4 of 14

4 of 14

3 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (12)

Mmus\Aqp2

12 of 14

Yes

Mmus\Aqp4

12 of 14

Yes

Mmus\Aqp5

11 of 14

Yes

Mmus\Aqp1

10 of 14

Yes

Mmus\Mip

10 of 14

Yes

Mmus\Aqp6

8 of 14

Yes

Mmus\Aqp8

7 of 14

Yes

5 of 14

3 of 14

3 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\aqp4

10 of 13

Yes

Xtro\aqp5

8 of 13

Yes

Xtro\mip

8 of 13

Yes

Xtro\kitlg

7 of 13

Yes

Xtro\LOC100489792

7 of 13

Yes

Xtro\LOC101731904

7 of 13

Yes

Xtro\LOC100487834

6 of 13

Yes

Xtro\XB5993457

6 of 13

Xtro\aqp8

5 of 13

Yes

Xtro\LOC100497434

5 of 13

Yes

Xtro\rars1

5 of 13

Xtro\aqp1

4 of 13

Yes

Xtro\aqp2

3 of 13

Yes

Xtro\aqp3

3 of 13

Yes

Xtro\aqp9

3 of 13

Yes

Xtro\LOC100498424

3 of 13

Yes

Xtro\sema4b

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\kctd15

1 of 13

Xtro\LOC100491830

1 of 13

Yes

Xtro\LOC101733960

1 of 13

Yes

Danio rerio (Zebrafish) (19)

Drer\aqp4

12 of 14

Yes

Drer\aqp1a.1

10 of 14

Yes

Drer\aqp1a.2

9 of 14

Yes

Drer\mipa

9 of 14

Yes

Drer\aqp8a.1

7 of 14

Yes

Drer\aqp8a.2

7 of 14

Yes

Drer\aqp8b

7 of 14

Yes

Drer\mipb

7 of 14

Yes

Drer\LOC101885864

6 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

1 of 14

Yes

Drer\aqp11

1 of 14

Drer\aqp12

1 of 14

Drer\LOC110438841

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\aqp-4

11 of 14

Yes

Cele\aqp-5

10 of 14

Yes

Cele\aqp-6

10 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\aqp-9

1 of 14

Cele\aqp-10

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AQP_ANOGA

12 of 12

Yes

6 of 12

4 of 12

3 of 12

3 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (38)

Atha\DELTA-TIP

11 of 13

Yes

Atha\TIP1;3

11 of 13

Yes

Atha\TIP2;2

11 of 13

Yes

Atha\TIP2;3

11 of 13

Yes

Atha\BETA-TIP

10 of 13

Yes

Atha\GAMMA-TIP

10 of 13

Yes

Atha\TIP2

10 of 13

Yes

Atha\TIP3;1

10 of 13

Yes

Atha\TIP4;1

10 of 13

Yes

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

Yes

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

Yes

Atha\AT2G29870

4 of 13

Yes

Atha\NIP5;1

4 of 13

Atha\NIP7;1

4 of 13

Yes

Atha\NIP6;1

3 of 13

Atha\SIP1;2

2 of 13

Yes

Atha\SIP1A

2 of 13

Yes

Atha\SIP2;1

2 of 13

Yes

Atha\AT2G16835

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\AQY1

9 of 13

Yes

Scer\YLL053C

7 of 13

Yes

Scer\AQY3

3 of 13

Scer\FPS1

3 of 13

Scer\AQY2

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC977.17

4 of 12

Yes

Spom\SPAC186.04c

1 of 12

Yes

Escherichia coli (enterobacterium) (2)

Ecol\aqpZ

8 of 11

Yes

Ecol\glpF

4 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Drip. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

11 of 13

9 of 13

9 of 13

9 of 13

9 of 13

bib

6 of 13

AQP

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

AQP2; aquaporin 2

model of nephrogenic diabetes insipidus type 2

IEA

(FlyBase, 2019-)

AQP5; aquaporin 5

model of Bothnian type palmoplantar keratoderma

IEA

(FlyBase, 2019-)

MIP; major intrinsic protein of lens fiber

model of cataract 15 multiple types

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AQP2; aquaporin 2

12 of 14

107777

DIABETES INSIPIDUS, NEPHROGENIC, 2, AUTOSOMAL; NDI2

nephrogenic diabetes insipidus type 2

AQP4; aquaporin 4

12 of 14

600308

MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 4, REMITTING; MLC4

AQP1; aquaporin 1 (Colton blood group)

11 of 14

107776

BLOOD GROUP, COLTON SYSTEM; CO

AQP5; aquaporin 5

11 of 14

600442

PALMOPLANTAR KERATODERMA, BOTHNIAN TYPE; PPKB

Bothnian type palmoplantar keratoderma

MIP; major intrinsic protein of lens fiber

9 of 14

154050

CATARACT 15, MULTIPLE TYPES; CTRCT15

cataract 15 multiple types

7 of 14

7 of 14

5 of 14

AQP3; aquaporin 3 (Gill blood group)

4 of 14

600170

GIL BLOOD GROUP

4 of 14

3 of 14

GLYCEROL QUANTITATIVE TRAIT LOCUS; GLYCQTL

Hsap\LOC100509620

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, Q9V5Z7 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62024

DroID - A comprehensive database of gene and protein interactions.

FBgn0015872

MIST (protein-protein) - An integrated Molecular Interaction Database

36236

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-64

Cytogenetic map

47F11-47F11

Sequence location

2R:11,411,203..11,429,645 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47F11-47F11

Limits computationally determined from genome sequence between P{lacW}Tapδ^k17005&P{lacW}k05103 and P{lacW}l(2)k13403^k13403&P{lacW}Egm^k14708

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

47F-47F

(Dow, 1995.10.17)

48A-48A

(Drees et al., 1987)

Experimentally Determined Recombination Data

Location

2-64

(FlyBase, 2016)

2-64.4

(Comeron et al., 2012)

(Dow, 1995.10.17, Drees et al., 1987)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17740

w¹¹¹⁸; PBac{PB}Drip^c05976

23425

w¹¹¹⁸; Mi{ET1}Drip^MB02194

59529

y¹ w^*; Mi{MIC}Drip^MI14532

96270

y¹ w^*; P{TKO-UAS.GS05919}attP40/CyO

34117

y¹ w^*; Mi{MIC}Drip^MI00887/SM6a

66782

y¹ w^*; Mi{Trojan-GAL4.0}Drip^{MI00887-TG4.0}/SM6a

91905

y¹ sc^* v¹ sev²¹; P{TKO.GS05471}attP40

44661

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02945}attP2

NIG-Fly

9023R-2

P{NIG.9023R}2

HMC02945

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02945}attP2

VDRC

v106911

P{KK107343}VIE-260B

v51936

w¹¹¹⁸; P{GD1936}v51936/TM3

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (71)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE60324

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015872

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015872

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Cabrero et al., 2020)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Transcription unit defined during molecular analysis of the en-inv gene region.

(Drees et al., 1987)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG9023

(Cabrero et al., 2014, Ibrahim et al., 2013, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Grieder et al., 2007, Klebes et al., 2005)

DRIP

(Rani et al., 2020, Ghimire et al., 2019, Tapadia and Gautam, 2011, Gautam and Tapadia, 2010, Kaufmann et al., 2005, Kaufmann et al., 2004, Wang et al., 2004)

Drip

(Rabah et al., 2025, Soltani et al., 2025, Agard et al., 2024, Avila et al., 2024, Liu et al., 2024, Hultmark and Andó, 2022, Sobrido-Cameán et al., 2022, Cattenoz et al., 2021, Dhawan et al., 2021, Dow et al., 2021, Jonusaite and Rodan, 2021, Pang et al., 2021, Reynolds et al., 2021, Cabrero et al., 2020, Cho et al., 2020, Choubey et al., 2020, Cohen et al., 2020, Flatt, 2020, Schiffman et al., 2020, Ghimire et al., 2019, Ruan et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Finn et al., 2015, Cabrero et al., 2014, Chintapalli et al., 2013, Denholm et al., 2013, Bergland et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Tsubouchi et al., 2012, Leiserson and Keshishian, 2011, Foley et al., 2010, Kwon et al., 2009, Grieder et al., 2007)

(Drees et al., 1987)

anon-48Aa

drip

(Saini et al., 2023, Saini et al., 2020, Paik et al., 2012, Schirling et al., 2010, Apel et al., 2008, Dow, 1995.10.17)

Name Synonyms

Drip

Drosophila Integral Protein

(Apel et al., 2008)

Drosophila integral protein

(Tsubouchi et al., 2012)

aquaporin

(Ni et al., 2006, Sinclair et al., 1998)

transcript group I

(Drees et al., 1987)

Secondary FlyBase IDs

FBgn0015156

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 65 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36236

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V5Z7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V5Z7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V5Z7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36236/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015872

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015872

FlyMine - An integrated database for Drosophila genomics

FBgn0015872

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9023

MARRVEL_MODEL - MARRVEL (model organism gene)

36236

Linkouts

BioGRID - A database of protein and genetic interactions.

62024

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015872

DroID - A comprehensive database of gene and protein interactions.

FBgn0015872

DRSC - Results frm RNAi screens

FBgn0015872

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015872

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015872

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0015872

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015872

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011257

MIST (protein-protein) - An integrated Molecular Interaction Database

36236

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

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