FB2025_05 , released December 11, 2025
Gene: Dmel\Orct
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General Information
Symbol
Dmel\Orct
Species
D. melanogaster
Name
Organic cation transporter
Annotation Symbol
CG6331
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019952
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Probably transports organic cations. (UniProt, Q9VCA2)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
95F8-95F8
Sequence location
Recombination map
3-84
RefSeq locus
NT_033777 REGION:24276260..24278792
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables transmembrane transporter activity
inferred from electronic annotation with InterPro:IPR005828, InterPro:IPR020846
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in apoptotic process
traceable author statement
(Taylor et al., 1997)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR005828
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
non-traceable author statement
(Taylor et al., 1997)
inferred from electronic annotation with InterPro:IPR005828
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (Q9VCA2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS -
Solute carrier family 22 (SLC22) members are organic cation, organic anion and organic zwiterrion/cations transporters. (Adapted from FBrf0179202 and PMID:23506881).
Protein Function (UniProtKB)
Probably transports organic cations.
(UniProt, Q9VCA2)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Orct for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VCA2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Possible gene duplication of CG13610

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Orct-RA
FBtr0084599
NM_079755
2533
548
Orct-RB
FBtr0334870
NM_001275979
2154
548
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Orct-PA
FBpp0083983
61.0
548
5.56
Q9VCA2
NP_524479
AAF56271
Orct-PB
FBpp0306893
61.0
548
5.56
Q9VCA2
NP_001262908
AGB96288
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

548 aa isoforms: Orct-PA, Orct-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

548, 370 (aa)

(Taylor et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orct using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 12
midline primordium
(Kearney et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
(Taylor et al., 1997)
Additional Descriptive Data

Orct transcripts are detected in embryos, third instar larvae, and adults on northern blots with the highest levels in larvae. Other stages were not tested.

(Taylor et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Orct in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Orct
Transgenic constructs containing regulatory region of Orct
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (33)
Hsap\SLC22A13
10 of 14
Yes
Yes
Hsap\SLC22A4
8 of 14
No
No
1  
Hsap\SLC22A5
8 of 14
No
No
Hsap\SLC22A2
7 of 14
No
No
3  
Hsap\SLC22A3
7 of 14
No
No
Hsap\SLC22A6
7 of 14
No
Yes
Hsap\SLC22A1
6 of 14
No
No
7  
Hsap\SLC22A7
6 of 14
No
No
Hsap\SLC22A8
6 of 14
No
Yes
Hsap\SLC22A11
6 of 14
No
No
Hsap\SLC22A12
6 of 14
No
No
Hsap\SLC22A14
6 of 14
No
Yes
Hsap\SLC22A16
6 of 14
No
No
1  
Hsap\SLC22A9
5 of 14
No
Yes
Hsap\SLC22A10
5 of 14
No
Yes
Hsap\SLC22A15
5 of 14
No
Yes
Hsap\SLC22A20P
5 of 14
No
No
Hsap\SLC22A24
5 of 14
No
No
Hsap\SLC22A25
5 of 14
No
Yes
Hsap\SLC22A23
4 of 14
No
Yes
Hsap\SLC22A17
3 of 14
No
Yes
Hsap\SLC22A31
3 of 14
No
Yes
Hsap\SVOPL
2 of 14
No
No
Hsap\SLC2A1
1 of 14
No
No
Hsap\SLC2A3
1 of 14
No
No
2  
Hsap\SLC2A9
1 of 14
No
No
Hsap\SLC2A11
1 of 14
No
No
Hsap\SLC2A12
1 of 14
No
No
Hsap\SLC2A14
1 of 14
No
No
Hsap\SV2A
1 of 14
No
No
Hsap\SV2B
1 of 14
No
No
Hsap\SV2C
1 of 14
No
No
Hsap\SVOP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (27)
Rnor\Slc22a1
10 of 14
Yes
Yes
Rnor\Slc22a2
10 of 14
Yes
Yes
Rnor\Slc22a3
10 of 14
Yes
Yes
Rnor\Slc22a5
8 of 14
No
No
Rnor\LOC685081
7 of 14
No
Yes
Rnor\Slc22a6
7 of 14
No
Yes
Rnor\Slc22a13
7 of 14
No
Yes
Rnor\Slc22a22
7 of 14
No
Yes
Rnor\Slc22a4
6 of 14
No
No
Rnor\Slc22a7
6 of 14
No
No
Rnor\Slc22a8
6 of 14
No
Yes
Rnor\Slc22a12
6 of 14
No
No
Rnor\Slc22a15
6 of 14
No
Yes
Rnor\Slc22a14
5 of 14
No
Yes
Rnor\Slc22a20
5 of 14
No
Yes
Rnor\Slc22a25
5 of 14
No
Yes
Rnor\UST4r
5 of 14
No
Yes
Rnor\Ust5r
5 of 14
No
Yes
Rnor\Slc22a23
4 of 14
No
Yes
Rnor\Slc22a17
3 of 14
No
Yes
Rnor\Svopl
2 of 14
No
No
Rnor\LOC303140
1 of 14
No
Yes
Rnor\Slc22a16
1 of 14
No
Yes
Rnor\Sv2a
1 of 14
No
No
Rnor\Sv2b
1 of 14
No
No
Rnor\Sv2c
1 of 14
No
No
Rnor\Svop
1 of 14
No
No
Mus musculus (laboratory mouse) (30)
Mmus\Slc22a21
11 of 14
Yes
Yes
Mmus\Slc22a4
10 of 14
No
Yes
Mmus\Slc22a5
10 of 14
No
Yes
Mmus\Slc22a1
8 of 14
No
Yes
Mmus\Slc22a2
8 of 14
No
Yes
Mmus\Slc22a3
8 of 14
No
Yes
Mmus\Slc22a13
7 of 14
No
No
Mmus\Slc22a14
7 of 14
No
Yes
Mmus\Slc22a22
7 of 14
No
Yes
Mmus\Slc22a6
6 of 14
No
No
Mmus\Slc22a7
6 of 14
No
No
Mmus\Slc22a8
6 of 14
No
No
Mmus\Slc22a12
6 of 14
No
No
Mmus\Slc22a20
6 of 14
No
No
Mmus\Slc22a16
5 of 14
No
No
Mmus\Slc22a19
5 of 14
No
Yes
Mmus\Slc22a26
5 of 14
No
Yes
Mmus\Slc22a27
5 of 14
No
No
Mmus\Slc22a28
5 of 14
No
No
Mmus\Slc22a29
5 of 14
No
No
Mmus\Slc22a30
5 of 14
No
No
Mmus\Slc22a15
4 of 14
No
No
Mmus\Slc22a23
4 of 14
No
Yes
Mmus\Slc22a17
3 of 14
No
Yes
Mmus\Svopl
2 of 14
No
No
Mmus\Slc22a13b
1 of 14
No
Yes
Mmus\Sv2a
1 of 14
No
No
Mmus\Sv2b
1 of 14
No
No
Mmus\Sv2c
1 of 14
No
No
Mmus\Svop
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (31)
Xtro\slc22a13
6 of 13
Yes
Yes
Xtro\slc22a4
5 of 13
No
Yes
Xtro\slc22a5
5 of 13
No
Yes
Xtro\slc22a2
4 of 13
No
Yes
Xtro\slc22a6
4 of 13
No
Yes
Xtro\slc22a8l.1
4 of 13
No
No
Xtro\slc22a8
4 of 13
No
Yes
Xtro\slc22a15.1
4 of 13
No
No
Xtro\slc22a15.2
4 of 13
No
No
Xtro\slc22a20p.1
4 of 13
No
Yes
Xtro\LOC100490946
3 of 13
No
Yes
Xtro\slc22a16
3 of 13
No
Yes
Xtro\slc22a23
3 of 13
No
Yes
Xtro\LOC116411083
2 of 13
No
No
Xtro\slc22a31
2 of 13
No
Yes
Xtro\arhgap25
1 of 13
No
Yes
Xtro\b3galnt2
1 of 13
No
No
Xtro\bfar
1 of 13
No
No
Xtro\cd99
1 of 13
No
Yes
Xtro\gmnn
1 of 13
No
No
Xtro\krt70
1 of 13
No
Yes
Xtro\nectin2
1 of 13
No
Yes
Xtro\pabir2
1 of 13
No
No
Xtro\slc2a5
1 of 13
No
No
Xtro\slc2a6
1 of 13
No
No
Xtro\slc2a11l2
1 of 13
No
No
Xtro\sv2a
1 of 13
No
No
Xtro\sv2b
1 of 13
No
No
Xtro\svopl
1 of 13
No
No
Xtro\tmem65
1 of 13
No
No
Xtro\ttc9b
1 of 13
No
No
Danio rerio (Zebrafish) (31)
Drer\si:dkey-166k12.1
10 of 14
Yes
Yes
Drer\si:dkey-119m7.4
9 of 14
No
Yes
Drer\slc22a13b
9 of 14
No
Yes
Drer\oct2
8 of 14
No
Yes
Drer\slc22a2
8 of 14
No
Yes
Drer\slc22a7b.2
7 of 14
No
Yes
Drer\slc22a7b.3
7 of 14
No
Yes
Drer\slc22a4
6 of 14
No
No
Drer\slc22a5
6 of 14
No
No
Drer\slc22a6l
6 of 14
No
Yes
Drer\slc22a7a
6 of 14
No
No
Drer\slc22a7b.1
6 of 14
No
Yes
Drer\slc22a13a
6 of 14
No
Yes
Drer\slc22a21
6 of 14
No
No
Drer\oatx
5 of 14
No
No
Drer\slc22a15
5 of 14
No
Yes
Drer\slc22a16
5 of 14
No
No
Drer\LOC566640
4 of 14
No
Yes
Drer\slc22a23
4 of 14
No
Yes
Drer\si:dkey-190l8.2
3 of 14
No
Yes
Drer\zmp:0000001102
3 of 14
No
No
Drer\svopl
2 of 14
No
No
Drer\slc2a13b
1 of 14
No
No
Drer\slc22a31
1 of 14
No
Yes
Drer\sv2a
1 of 14
No
No
Drer\sv2ba
1 of 14
No
No
Drer\sv2bb
1 of 14
No
No
Drer\sv2ca
1 of 14
No
No
Drer\sv2
1 of 14
No
No
Drer\svopa
1 of 14
No
No
Drer\svopb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (33)
Cele\F45E10.2
10 of 14
Yes
Yes
Cele\Y82E9BR.16
10 of 14
Yes
Yes
Cele\C06H5.6
6 of 14
No
Yes
Cele\str-176
6 of 14
No
Yes
Cele\B0252.3
5 of 14
No
Yes
Cele\B0361.11
5 of 14
No
Yes
Cele\C46C2.2
5 of 14
No
Yes
Cele\F17C11.12
5 of 14
No
Yes
Cele\F23F12.3
5 of 14
No
Yes
Cele\K05F1.6
5 of 14
No
Yes
Cele\oat-1
5 of 14
No
No
Cele\oct-2
5 of 14
No
No
Cele\Y66D12A.13
5 of 14
No
Yes
Cele\C44C10.3
4 of 14
No
No
Cele\F23F12.13
4 of 14
No
No
Cele\F32H5.4
4 of 14
No
Yes
Cele\K11D9.3
4 of 14
No
Yes
Cele\oct-1
4 of 14
No
No
Cele\T05A1.5
4 of 14
No
Yes
Cele\T12B3.2
4 of 14
No
Yes
Cele\T22F7.1
4 of 14
No
No
Cele\Y51A2D.18
4 of 14
No
Yes
Cele\K09E9.1
3 of 14
No
Yes
Cele\pes-23
3 of 14
No
Yes
Cele\ZK892.3
3 of 14
No
Yes
Cele\suex-2
2 of 14
No
No
Cele\T08B1.1
2 of 14
No
Yes
Cele\Y57G11C.23
2 of 14
No
Yes
Cele\fgt-1
1 of 14
No
No
Cele\hmit-1.1
1 of 14
No
No
Cele\hmit-1.2
1 of 14
No
No
Cele\R09B5.11
1 of 14
No
No
Cele\svop-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (33)
Agam\AgaP_AGAP004309
12 of 12
Yes
Yes
Agam\AgaP_AGAP003039
6 of 12
No
No
Agam\AgaP_AGAP003038
4 of 12
No
No
Agam\AgaP_AGAP003303
4 of 12
No
No
Agam\AgaP_AGAP005530
4 of 12
No
No
Agam\AgaP_AGAP006609
4 of 12
No
No
Agam\AgaP_AGAP008335
4 of 12
No
No
Agam\AgaP_AGAP010509
4 of 12
No
No
Agam\AgaP_AGAP013029
4 of 12
No
No
Agam\AgaP_AGAP001202
3 of 12
No
No
Agam\AgaP_AGAP004104
3 of 12
No
No
Agam\AgaP_AGAP004107
3 of 12
No
No
Agam\AgaP_AGAP012383
3 of 12
No
No
Agam\AgaP_AGAP004457
2 of 12
No
No
Agam\AgaP_AGAP000128
1 of 12
No
No
Agam\AgaP_AGAP000732
1 of 12
No
No
Agam\AgaP_AGAP000785
1 of 12
No
No
Agam\AgaP_AGAP001160
1 of 12
No
No
Agam\AgaP_AGAP002826
1 of 12
No
No
Agam\AgaP_AGAP003020
1 of 12
No
No
Agam\AgaP_AGAP004156
1 of 12
No
No
Agam\AgaP_AGAP004157
1 of 12
No
No
Agam\AgaP_AGAP004350
1 of 12
No
No
Agam\AgaP_AGAP005600
1 of 12
No
No
Agam\AgaP_AGAP007660
1 of 12
No
No
Agam\AgaP_AGAP007667
1 of 12
No
No
Agam\AgaP_AGAP008721
1 of 12
No
No
Agam\AgaP_AGAP009745
1 of 12
No
No
Agam\AgaP_AGAP010892
1 of 12
No
No
Agam\AgaP_AGAP011680
1 of 12
No
No
Agam\AgaP_AGAP012218
1 of 12
No
No
Agam\AgaP_AGAP012761
1 of 12
No
No
Agam\AgaP_AGAP013063
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (55)
Atha\OCT4
10 of 13
Yes
Yes
Atha\OCT3
7 of 13
No
No
Atha\OCT1
6 of 13
No
Yes
Atha\OCT2
6 of 13
No
No
Atha\OCT5
5 of 13
No
Yes
Atha\OCT6
4 of 13
No
No
Atha\AT4G08878
2 of 13
No
Yes
Atha\PHT1;1
2 of 13
No
Yes
Atha\PHT1;2
2 of 13
No
Yes
Atha\PHT1;3
2 of 13
No
Yes
Atha\PHT1;4
2 of 13
No
Yes
Atha\PHT1;5
2 of 13
No
Yes
Atha\PHT1;6
2 of 13
No
No
Atha\PHT1;7
2 of 13
No
Yes
Atha\PHT1;8
2 of 13
No
Yes
Atha\PHT1;9
2 of 13
No
Yes
Atha\AT1G05030
1 of 13
No
No
Atha\AT1G08890
1 of 13
No
No
Atha\AT1G08900
1 of 13
No
No
Atha\AT1G19450
1 of 13
No
No
Atha\AT1G54730
1 of 13
No
No
Atha\AT1G67300
1 of 13
No
No
Atha\AT2G18480
1 of 13
No
No
Atha\AT2G20780
1 of 13
No
No
Atha\AT2G48020
1 of 13
No
No
Atha\AT3G05155
1 of 13
No
No
Atha\AT3G05160
1 of 13
No
No
Atha\AT3G05165
1 of 13
No
No
Atha\AT3G05400
1 of 13
No
No
Atha\AT3G19940
1 of 13
No
No
Atha\AT3G20460
1 of 13
No
No
Atha\AT4G04750
1 of 13
No
No
Atha\AT4G04760
1 of 13
No
No
Atha\AT5G17010
1 of 13
No
No
Atha\AT5G18840
1 of 13
No
No
Atha\AT5G59250
1 of 13
No
No
Atha\ERD6
1 of 13
No
No
Atha\INT1
1 of 13
No
No
Atha\INT2
1 of 13
No
No
Atha\INT3
1 of 13
No
No
Atha\INT4
1 of 13
No
No
Atha\NiaP
1 of 13
No
No
Atha\PGLCT
1 of 13
No
No
Atha\PMT5
1 of 13
No
No
Atha\PMT6
1 of 13
No
No
Atha\SFP1
1 of 13
No
No
Atha\SFP2
1 of 13
No
No
Atha\SGB1
1 of 13
No
No
Atha\STP1
1 of 13
No
No
Atha\STP2
1 of 13
No
No
Atha\STP9
1 of 13
No
No
Atha\TMT1
1 of 13
No
No
Atha\TMT2
1 of 13
No
No
Atha\TMT3
1 of 13
No
No
Atha\VGT1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (28)
Scer\PHO84
3 of 13
Yes
Yes
Scer\GIT1
2 of 13
No
Yes
Scer\CIN10
1 of 13
No
No
Scer\GAL2
1 of 13
No
No
Scer\HXT1
1 of 13
No
No
Scer\HXT2
1 of 13
No
No
Scer\HXT3
1 of 13
No
No
Scer\HXT4
1 of 13
No
No
Scer\HXT5
1 of 13
No
No
Scer\HXT6
1 of 13
No
No
Scer\HXT7
1 of 13
No
No
Scer\HXT8
1 of 13
No
No
Scer\HXT9
1 of 13
No
No
Scer\HXT10
1 of 13
No
No
Scer\HXT13
1 of 13
No
No
Scer\HXT14
1 of 13
No
No
Scer\HXT15
1 of 13
No
No
Scer\HXT16
1 of 13
No
No
Scer\HXT17
1 of 13
No
No
Scer\ITR1
1 of 13
No
No
Scer\ITR2
1 of 13
No
No
Scer\MAL11
1 of 13
No
No
Scer\MAL31
1 of 13
No
No
Scer\MPH2
1 of 13
No
No
Scer\MPH3
1 of 13
No
No
Scer\RGT2
1 of 13
No
No
Scer\SNF3
1 of 13
No
No
Scer\VPS73
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (9)
Spom\SPAPB1E7.08c
3 of 12
Yes
No
Spom\fnx1
1 of 12
No
Yes
Spom\fnx2
1 of 12
No
Yes
Spom\itr2
1 of 12
No
No
Spom\SPAC23D3.12
1 of 12
No
No
Spom\SPBC8E4.01c
1 of 12
No
No
Spom\SPBC1271.09
1 of 12
No
No
Spom\SPBC1683.01
1 of 12
No
No
Spom\SPCC2H8.02
1 of 12
No
No
Escherichia coli (enterobacterium) (16)
Ecol\ygcS
5 of 11
Yes
Yes
Ecol\yaaU
4 of 11
No
Yes
Ecol\ydjK
4 of 11
No
No
Ecol\ydjE
3 of 11
No
Yes
Ecol\araE
1 of 11
No
No
Ecol\kgtP
1 of 11
No
Yes
Ecol\mdfA
1 of 11
No
Yes
Ecol\mdtM
1 of 11
No
Yes
Ecol\mhpT
1 of 11
No
No
Ecol\nanT
1 of 11
No
No
Ecol\nanX
1 of 11
No
No
Ecol\proP
1 of 11
No
No
Ecol\shiA
1 of 11
No
No
Ecol\ydfJ
1 of 11
No
Yes
Ecol\yhjE
1 of 11
No
Yes
Ecol\ynfM
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Orct. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (46)
Orct2
13 of 13
Balat
9 of 13
CG4630
9 of 13
CG8654
9 of 13
CarT
8 of 13
CG6126
8 of 13
CG6356
8 of 13
CG10486
8 of 13
CG42269
8 of 13
CG5592
7 of 13
CG6006
7 of 13
CG7458
7 of 13
CG8925
7 of 13
SLC22A
7 of 13
CG6231
6 of 13
CG7084
6 of 13
CG7342
6 of 13
CG14855
6 of 13
CG16727
6 of 13
CG17752
6 of 13
CG7333
5 of 13
CG14857
5 of 13
CG4459
4 of 13
CG4462
4 of 13
CG4465
4 of 13
CG14856
4 of 13
CG17751
4 of 13
CG44098
4 of 13
CG3690
3 of 13
CG4324
3 of 13
CG12783
3 of 13
CG14691
3 of 13
CG15221
3 of 13
CG31103
3 of 13
CG31106
3 of 13
CG31272
3 of 13
CG33233
3 of 13
CG33234
3 of 13
sv2
2 of 13
CG1213
1 of 13
CG3285
1 of 13
CG6484
1 of 13
CG8249
1 of 13
CG15408
1 of 13
nebu
1 of 13
Tret1l
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC22A13; solute carrier family 22 member 13
    10 of 14
    604047
        SLC22A4; solute carrier family 22 member 4
        8 of 14
        604190
         
        SLC22A5; solute carrier family 22 member 5
        8 of 14
        603377
        SLC22A2; solute carrier family 22 member 2
        7 of 14
        602608
             
            SLC22A3; solute carrier family 22 member 3
            7 of 14
            604842
                SLC22A6; solute carrier family 22 member 6
                7 of 14
                607582
                    SLC22A1; solute carrier family 22 member 1
                    6 of 14
                    602607
                         
                        SLC22A7; solute carrier family 22 member 7
                        6 of 14
                        604995
                            SLC22A8; solute carrier family 22 member 8
                            6 of 14
                            607581
                                SLC22A11; solute carrier family 22 member 11
                                6 of 14
                                607097
                                    SLC22A12; solute carrier family 22 member 12
                                    6 of 14
                                    607096
                                      SLC22A14; solute carrier family 22 member 14
                                      6 of 14
                                      604048
                                          SLC22A16; solute carrier family 22 member 16
                                          6 of 14
                                          608276
                                               
                                              SLC22A9; solute carrier family 22 member 9
                                              5 of 14
                                              607579
                                                  SLC22A10; solute carrier family 22 member 10 (gene/pseudogene)
                                                  5 of 14
                                                  607580
                                                      SLC22A15; solute carrier family 22 member 15
                                                      5 of 14
                                                      608275
                                                          SLC22A20P; solute carrier family 22 member 20, pseudogene
                                                          5 of 14
                                                          611696
                                                              SLC22A24; solute carrier family 22 member 24
                                                              5 of 14
                                                              611698
                                                                  SLC22A25; solute carrier family 22 member 25
                                                                  5 of 14
                                                                  610792
                                                                      SLC22A23; solute carrier family 22 member 23
                                                                      4 of 14
                                                                      611697
                                                                          SLC22A17; solute carrier family 22 member 17
                                                                          3 of 14
                                                                          611461
                                                                              SLC22A31; solute carrier family 22 member 31
                                                                              3 of 14
                                                                                  Functional Complementation Data
                                                                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                                  Interactions
                                                                                  Summary of Physical Interactions
                                                                                  Interaction Browsers
                                                                                  Summary of Genetic Interactions
                                                                                  Interaction Browsers
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  External Data
                                                                                  Linkouts
                                                                                  BioGRID - A database of protein and genetic interactions.
                                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                                  Pathways
                                                                                  Signaling Pathways (FlyBase)
                                                                                  Metabolic Pathways
                                                                                  FlyBase
                                                                                  External Links
                                                                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                                                  External Data
                                                                                  Class of Gene
                                                                                  Genomic Location and Detailed Mapping Data
                                                                                  Chromosome (arm)
                                                                                  3R
                                                                                  Recombination map
                                                                                  3-84
                                                                                  Cytogenetic map
                                                                                  95F8-95F8
                                                                                  Sequence location
                                                                                  FlyBase Computed Cytological Location
                                                                                  Cytogenetic map
                                                                                  Evidence for location
                                                                                  95F8-95F8
                                                                                  Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
                                                                                  Experimentally Determined Cytological Location
                                                                                  Cytogenetic map
                                                                                  Notes
                                                                                  References
                                                                                  FlyBase curator comment: the sequence contained in the Y12399 accession is chimeric, containing sequences from two separate genomic regions; part of the Y12399 sequence corresponds to CG6331 (Orct) at 95F, while the other part maps to an intron of CG17834 at 29D (see Shirras, 2005.5.31, personal communication to FlyBase).
                                                                                  (Shirras, 1997.4.7)
                                                                                  Experimentally Determined Recombination Data
                                                                                  Location

                                                                                  3-84

                                                                                  (FlyBase, 2016)

                                                                                  3-83.0

                                                                                  (Comeron et al., 2012)
                                                                                  Left of (cM)
                                                                                  Right of (cM)
                                                                                  Notes
                                                                                  Stocks and Reagents
                                                                                  Stocks (7)
                                                                                  Genomic Clones (15)
                                                                                   

                                                                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                                  cDNA Clones (34)
                                                                                   

                                                                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                                  cDNA clones, fully sequenced
                                                                                  BDGP DGC clones
                                                                                  Other clones
                                                                                  Drosophila Genomics Resource Center cDNA clones

                                                                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                                  cDNA Clones, End Sequenced (ESTs)
                                                                                  BDGP DGC clones
                                                                                  Other clones
                                                                                  RNAi and Array Information
                                                                                  Linkouts
                                                                                  DRSC - Results frm RNAi screens
                                                                                  Antibody Information
                                                                                  Laboratory Generated Antibodies
                                                                                   
                                                                                  Commercially Available Antibodies
                                                                                   
                                                                                  Cell Line Information
                                                                                  Publicly Available Cell Lines
                                                                                   
                                                                                    Other Stable Cell Lines
                                                                                     
                                                                                      Other Comments

                                                                                      In FBrf0099562, the Orct locus is stated to be adjacent to the P{PZ}lmg03424 insertion, which is at 29D. However, the protein sequence of Orct (Q9VCA2) corresponds to the annotation CG6331, which maps to 95F. The confusion arose because the Y12399 sequence accession is chimeric, containing sequences from two separate genomic regions; part of the Y12399 sequence corresponds to CG6331 (i.e. Orct) at 95F, while the other part maps to an intron of CG17834 (which is adjacent to lmg) at 29D.

                                                                                      (Shirras, 2005.5.31)

                                                                                      FlyBase curator comment: in FBrf0125046, the Orct locus is stated to span Acer and lmg which are at 29D. However, this is now known to be an error, with Orct corresponding to annotation CG6331 at 95F. The confusion arose because the Orct accession Y12399 is chimeric (see Shirras, 2005.5.31, personal communication to FlyBase).

                                                                                      (Shirras, 2000.1.5)

                                                                                      FlyBase curator comment: in FBrf0099562, the Orct locus is stated to be adjacent to the P{PZ}lmg03424 insertion, which is at 29D. However, this is now known to be an error, with Orct corresponding to annotation CG6331 at 95F. The confusion arose because the Orct accession Y12399 is chimeric (see Shirras, 2005.5.31, personal communication to FlyBase).

                                                                                      (Taylor et al., 1997)
                                                                                      Relationship to Other Genes
                                                                                      Source for database merge of
                                                                                      Additional comments
                                                                                      Nomenclature History
                                                                                      Source for database identify of

                                                                                      Source for identity of: Orct CG6331

                                                                                      (Kodira, 1999.11)
                                                                                      Nomenclature comments
                                                                                      Etymology
                                                                                      Synonyms and Secondary IDs (6)
                                                                                      Datasets (0)
                                                                                      Study focus (0)
                                                                                      Experimental Role
                                                                                      Project
                                                                                      Project Type
                                                                                      Title
                                                                                      Study result (0)
                                                                                      Result
                                                                                      Result Type
                                                                                      Title
                                                                                      External Crossreferences and Linkouts ( 52 )
                                                                                      Sequence Crossreferences
                                                                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                                      Other crossreferences
                                                                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                      FlyMine - An integrated database for Drosophila genomics
                                                                                      InterPro - A database of protein families, domains and functional sites
                                                                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                      Linkouts
                                                                                      BioGRID - A database of protein and genetic interactions.
                                                                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                      DroID - A comprehensive database of gene and protein interactions.
                                                                                      DRSC - Results frm RNAi screens
                                                                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                      Flygut - An atlas of the Drosophila adult midgut
                                                                                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                                                      References (68)