FlyBase Gene Report: Dmel\SLC22A

General Information

Symbol

Dmel\SLC22A

Species

D. melanogaster

Name

SLC22A family member

Annotation Symbol

CG7442

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037140

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

SLC22A family member (SLC22A) encodes a plasma membrane transporter and a member of the conserved family of SLC22A transporters. The product of SLC22A is preferentially localized in the dendrites of mushroom body neurons, where it functions to terminate synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine. Impairing the function of SLC22A enhances the acquisition and retention of olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent. [Date last reviewed: 2018-10-25] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

79A4-79A4

Sequence location

3L:21,934,704..21,938,636 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21934704..21938636

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables choline transmembrane transporter activity

inferred from direct assay

(Gai et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables transmembrane transporter activity

inferred from electronic annotation with InterPro:IPR005828, InterPro:IPR020846

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in acetylcholine transport

inferred from direct assay

(Gai et al., 2016)

involved_in memory

inferred from mutant phenotype

(Gai et al., 2016)

involved_in negative regulation of synaptic transmission, cholinergic

inferred from mutant phenotype

(Gai et al., 2016)

involved_in regulation of olfactory learning

inferred from mutant phenotype

(Gai et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR005828

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR005828

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS -: Solute carrier family 22 (SLC22) members are organic cation, organic anion and organic zwiterrion/cations transporters. (Adapted from FBrf0179202 and PMID:23506881).

Summary (Interactive Fly)

a plasma membrane transporter - localizes in the dendrites of mushroom body neurons - terminates synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine - enhances olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SLC22A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VNX2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SLC22A-RA

FBtr0078471

NM_141113

2085

568

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SLC22A-PA

FBpp0078124

63.3

568

6.82

Q9VNX2

NP_649370

AAF51793

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VNX2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SLC22A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG7442_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.65

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

SLC22A protein is detected in the ventral and lateral part o the mushroom body calyx and the ventral side of the protocerebral bridge. Expression in alpha/beta Kenyon cells is strongest in the neuropil whereas it is also detected in cell bodies of alpha'/beta' Kenyon cells.

(Gai et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SLC22A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SLC22A

View exonic expression by tissue for Dmel\SLC22A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40437/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037140

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037140

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037140

Flygut - An atlas of the Drosophila adult midgut

FBgn0037140

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SLC22A

Transgenic constructs containing regulatory region of SLC22A

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6137

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^da.PU

SLC22A^GL00080

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SLC22A^GD2773

viable, with Scer\GAL4^Mef2.PR

SLC22A^GD2773

viable, with Scer\GAL4^pnr-MD237

SLC22A^GD2773

viable, with Scer\GAL4^tin.CΔ4

SLC22A^GD2773

Other Phenotypes

Allele

abnormal memory | adult stage, with Ecol\lexA^GMR13F02

abnormal memory | adult stage, with Scer\GAL4^238Y

abnormal memory | adult stage, with Scer\GAL4^c305a

SLC22A^KK112539

abnormal memory | adult stage, with Scer\GAL4^c747

SLC22A^KK112539

abnormal memory | adult stage, with Scer\GAL4^ey-OK107

abnormal memory | adult stage, with Scer\GAL4^GMR13F02

abnormal memory | adult stage, with Scer\GAL4^GMR28H05

SLC22A^KK112539

abnormal memory | adult stage, with Scer\GAL4^nSyb.PU

SLC22A^KK112539

abnormal memory | adult stage, with Scer\GAL4^ple.PU

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\SLC22A1

6 of 14

Yes

Hsap\SLC22A3

6 of 14

Yes

Hsap\SLC22A6

6 of 14

Yes

Hsap\SLC22A11

6 of 14

Yes

Hsap\SLC22A12

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Slc22a1

6 of 14

Yes

Rnor\Slc22a3

6 of 14

Yes

Rnor\Slc22a6

6 of 14

Yes

Rnor\Slc22a12

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

1 of 14

Yes

Rnor\Slc22a16

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Slc22a1

6 of 14

Yes

Mmus\Slc22a3

6 of 14

Yes

Mmus\Slc22a6

6 of 14

Yes

Mmus\Slc22a12

6 of 14

Yes

Mmus\Slc22a20

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (19)

Xtro\slc22a8l.1

4 of 13

Yes

Xtro\slc22a13

4 of 13

Yes

Xtro\slc22a15.1

4 of 13

Yes

Xtro\slc22a15.2

4 of 13

Yes

Xtro\slc22a6

3 of 13

Xtro\slc22a8

3 of 13

Xtro\slc22a23

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\oatx

5 of 14

Yes

Drer\oct2

5 of 14

Yes

Drer\si:dkey-119m7.4

5 of 14

Yes

Drer\si:dkey-166k12.1

5 of 14

Yes

Drer\slc22a2

5 of 14

Yes

Drer\slc22a6l

5 of 14

Yes

Drer\slc22a13a

5 of 14

Yes

Drer\slc22a13b

5 of 14

Yes

Drer\LOC566640

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (33)

Cele\oat-1

6 of 14

Yes

Cele\F23F12.13

5 of 14

Yes

Cele\T22F7.1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\oct-1

3 of 14

Cele\suex-2

3 of 14

Yes

Cele\Y51A2D.18

3 of 14

Cele\ZK892.3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (31)

Agam\AgaP_AGAP001202

11 of 12

Yes

Agam\AgaP_AGAP012383

11 of 12

Yes

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (43)

Atha\OCT2

6 of 13

Yes

Atha\OCT3

6 of 13

Yes

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\CIN10

1 of 13

Yes

Scer\GIT1

1 of 13

Yes

Scer\ITR1

1 of 13

Yes

Scer\ITR2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAPB1E7.08c

2 of 12

Yes

Spom\SPBC1271.09

1 of 12

Escherichia coli (enterobacterium) (6)

Ecol\ydjK

2 of 11

Yes

Ecol\ygcS

2 of 11

Yes

1 of 11

1 of 11

1 of 11

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SLC22A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (41)

11 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

sv2

2 of 13

CG1213

1 of 13

nebu

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC22A1; solute carrier family 22 member 1

6 of 14

602607

SLC22A3; solute carrier family 22 member 3

6 of 14

604842

SLC22A6; solute carrier family 22 member 6

6 of 14

607582

SLC22A11; solute carrier family 22 member 11

6 of 14

607097

SLC22A12; solute carrier family 22 member 12

6 of 14

607096

HYPOURICEMIA, RENAL, 1; RHUC1

SLC22A2; solute carrier family 22 member 2

5 of 14

602608

SLC22A8; solute carrier family 22 member 8

5 of 14

607581

SLC22A13; solute carrier family 22 member 13

5 of 14

604047

SLC22A14; solute carrier family 22 member 14

5 of 14

604048

SLC22A24; solute carrier family 22 member 24

5 of 14

611698

SLC22A4; solute carrier family 22 member 4

4 of 14

604190

RHEUMATOID ARTHRITIS; RA

rheumatoid arthritis

SLC22A5; solute carrier family 22 member 5

4 of 14

603377

CARNITINE DEFICIENCY, SYSTEMIC PRIMARY; CDSP

systemic primary carnitine deficiency disease

SLC22A7; solute carrier family 22 member 7

4 of 14

604995

SLC22A9; solute carrier family 22 member 9

4 of 14

607579

SLC22A10; solute carrier family 22 member 10 (gene/pseudogene)

4 of 14

607580

SLC22A15; solute carrier family 22 member 15

4 of 14

608275

SLC22A16; solute carrier family 22 member 16

4 of 14

608276

SLC22A20P; solute carrier family 22 member 20, pseudogene

4 of 14

611696

SLC22A25; solute carrier family 22 member 25

4 of 14

610792

SLC22A23; solute carrier family 22 member 23

3 of 14

611697

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

SLC22A

suppressible

Ace

(Gai et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ace

suppressible

SLC22A

(Gai et al., 2016)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037140

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Carnitine metabolism

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

79A4-79A4

Sequence location

3L:21,934,704..21,938,636 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

79A4-79A4

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

97656

y¹ w^*; TI{CRIMIC.TG4.0}SLC22A^{CR02868-TG4.0}

35817

y¹ sc^* v¹ sev²¹; P{TRiP.GL00080}attP2

NIG-Fly

HMJ24109

y¹ v¹; P{TRiP.HMJ24109}attP40/CyO

VDRC

v106555

P{KK112539}VIE-260B

v8450

w¹¹¹⁸; P{GD2773}v8450

v341797

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00935}attP40/CyO-GFP

v341929

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01200}attP40/CyO-GFP

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (239)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE69557

Other clones

DPiM_RE69557

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037140

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RP003000926
RP003001436
RP003003437
RP003009600
RP003015546
RP003020035
RP003022436
RP003028627
RP003031949
RP003035883
RP003037161
RP003037398
RP003039415
RP003043183
RP003043585
RP003044796
RP003045192
RP003045765
RP003048656
RP003049171
RP003049489
RP003050862
RP003061855
RP003063707
RP003066011
RP003066746
RP003066965
RP003068742
RP003071685
RP003072829
RP003077705
RP003078496
RP003085235
RP003087282
RP003088533
RP003089598
RP003089890
RP003091528
RP003094744
RP003099476
RP003100379
RP003101854
RP003102077
RP003105004
RP003112679
RP003116721
RP003118514
RP003120519
RP003123255
RP003123715
RP003124227
RP003130360
RP003135444
RP003138513
RP003150083
RP003155831
RP003158449
RP003160210
RP003162108
RP003164997
RP003166814
RP003169558
RP003172491
RP003174734
RP003176428
RP003176808
RP003181021
RP003181743
RP003184034
RP003184671
RP003186119
RP003186430
RP003187559
RP003189475
RP003193371
RP003196358
RP003197105
RP003197959
RP003199363
RP003199986
RP003201385
RP003201917
RP003203901
RP003204478
RP003204972
RP003208025
RP003209761
RP003210711
RP003212180
RP003213831
RP003214079
RP003215267
RP003216542
RP003217400
RP003219151
RP003222729
RP003224000
RP003224671
RP003228784
RP003234000
RP003236558
RP003238100
RP003238726
RP003239908
RP003241406
RP003243172
RP003246140
RP003250748
RP003252478
RP003254753
RP003255263
RP003256990
RP003265064
RP003268013
RP003268625
RP003272786
RP003276782
RP003280245
RP003281520
RP003285245
RP003288061
RP003295556
RP003296712
RP003307053
RP003312864
RP003334847
RP003338535
RP003339387
RP003345874
RP003354449
RP003356054
RP003357704
RP003358263
RP003359282
RP003373512
RP003374341
RP003376902
RP003377855
RP003378926
RP003389879
RP003402416
RP003403326
RP003405510
RP003417554
RP003418744
RP003420387
RP003421816
RP003423458
RP003424309
RP003425999
RP003426622
RP003428257
RP003434972
RP003436410
RP003438332
RP003440706
RP003449323
RP003450943
RP003457007
RP003457127
RP003460118
RP003461197
RP003466545
RP003468012
RP003468371
RP003473768
RP003473957
RP003476545
RP003479266
RP003479446
RP003480512
RP003485213
RP003485429
RP003489569
RP003492493
RP003500995
RP003503171
RP003505144
RP003505157
RP003505828
RP003512479
RP003515781
RP003522259
RP003522999
RP003524940
RP003525924
RP003527682
RP003527871
RP003529775
RP003530660
RP003535596
RP003536444
RP003539990
RP003540499
RP003544863
RP003545690
RP003548403
RP003555634
RP003559149
RP003560391
RP003560641
RP003561862
RP003566200
RP003567365
RP003574961
RP003579000
RP003580575
RP003585611
RP003586106
RP003586441
RP003586700
RP003598459
RP003601254
RP003603488
RP003611264
RP003611955
RP003618428
RP003633017
RP003635492
RP003635801
RP003638141
RP003639195
RP003640762
RP003650239
RP003654497
RP003656859
RP003662249
RP003663149
RP003674787
RP003675316
RP003676432

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037140

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Gai et al., 2016)

polyclonal

(Gai et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

SLC22A limits normal memory formation, acting by regulating cholinergic neurotransmission at the projection neuron:mushroom body neuron synapse.

(Gai et al., 2016)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: SLC22A CG7442

(Gai et al., 2016)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG7442

(National Institute of Genetics Fly Stocks, 2023-, Engelhart et al., 2020, Velentzas et al., 2018, Han et al., 2017, Gai et al., 2016, Short and Lazzaro, 2013, Smibert et al., 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5)

DmSLC22A

(Gai et al., 2016)

DmSLC22a

(Davis, 2023)

SLC22A

(Fisher et al., 2023, Ceder and Fredriksson, 2022, Rounds et al., 2022, Engelhart et al., 2020, Gene Disruption Project members, 2018-, Hall et al., 2018, Han et al., 2017)

Slc22a15

(Engelhart et al., 2020)

Name Synonyms

SLC22A family member

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40437

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VNX2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VNX2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VNX2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40437/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037140

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037140

FlyMine - An integrated database for Drosophila genomics

FBgn0037140

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7442

MARRVEL_MODEL - MARRVEL (model organism gene)

40437

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037140

DroID - A comprehensive database of gene and protein interactions.

FBgn0037140

DRSC - Results frm RNAi screens

FBgn0037140

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG7442_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037140

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037140

Flygut - An atlas of the Drosophila adult midgut

FBgn0037140

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037140

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Carnitine metabolism

References (38)

The following external sites may use different assemblies or annotations than FlyBase.

-0.65

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