FB2026_02 , released June 18, 2026
Gene: Dmel\Orct2
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General Information
Symbol
Dmel\Orct2
Species
D. melanogaster
Name
Organic cation transporter 2
Annotation Symbol
CG13610
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086365
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Organic cation transporter 2 (Orct2) encodes an organic cation transporter of the major facilitator superfamily, and a transcriptional target of the insulin receptor pathway. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

EP1072

Key Links
Genomic Location
Cytogenetic map
95F8-95F8
Sequence location
Recombination map
3-84
RefSeq locus
NT_033777 REGION:24273029..24275728
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables transmembrane transporter activity
inferred from sequence or structural similarity with UniProtKB:Q9U539
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR005828, InterPro:IPR020846
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in positive regulation of cell growth
inferred from mutant phenotype
(Herranz et al., 2006)
involved_in positive regulation of multicellular organism growth
inferred from mutant phenotype
(Herranz et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane transport
inferred from sequence or structural similarity with UniProtKB:Q9U539
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR005828
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR005828
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (Q95R48)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Organic cation transporter 2 (Orct2) encodes an organic cation transporter of the major facilitator superfamily, and a transcriptional target of the insulin receptor pathway. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS -
Solute carrier family 22 (SLC22) members are organic cation, organic anion and organic zwiterrion/cations transporters. (Adapted from FBrf0179202 and PMID:23506881).
Protein Function (UniProtKB)
Probably transports organic cations.
(UniProt, Q95R48)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Orct2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q95R48)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.56

Possible gene duplication of Orct:CG6331

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Orct2-RA
FBtr0084598
NM_142981
2248
567
Orct2-RB
FBtr0334869
NM_001275978
2700
567
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Orct2-PA
FBpp0083982
63.2
567
6.40
Q95R48
NP_651238
AAF56270
Orct2-PB
FBpp0306892
63.2
567
6.40
Q95R48
NP_001262907
AGB96287
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

567 aa isoforms: Orct2-PA, Orct2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orct2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.77

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic proventriculus
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Orct2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Orct2
Transgenic constructs containing regulatory region of Orct2
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (35)
Hsap\SLC22A13
10 of 14
Yes
Yes
Hsap\SLC22A4
8 of 14
No
No
1  
Hsap\SLC22A5
8 of 14
No
No
Hsap\SLC22A2
7 of 14
No
No
3  
Hsap\SLC22A3
7 of 14
No
No
Hsap\SLC22A6
7 of 14
No
Yes
Hsap\SLC22A1
6 of 14
No
No
7  
Hsap\SLC22A7
6 of 14
No
No
Hsap\SLC22A8
6 of 14
No
Yes
Hsap\SLC22A11
6 of 14
No
No
Hsap\SLC22A12
6 of 14
No
No
Hsap\SLC22A14
6 of 14
No
Yes
Hsap\SLC22A16
6 of 14
No
No
1  
Hsap\SLC22A9
5 of 14
No
Yes
Hsap\SLC22A10
5 of 14
No
Yes
Hsap\SLC22A15
5 of 14
No
Yes
Hsap\SLC22A20P
5 of 14
No
No
Hsap\SLC22A24
5 of 14
No
No
Hsap\SLC22A25
5 of 14
No
Yes
Hsap\SLC22A23
4 of 14
No
Yes
Hsap\SLC22A17
3 of 14
No
Yes
Hsap\SLC22A31
3 of 14
No
Yes
Hsap\SVOPL
2 of 14
No
No
Hsap\MFSD14A
1 of 14
No
No
Hsap\SLC2A1
1 of 14
No
No
Hsap\SLC2A2
1 of 14
No
No
Hsap\SLC2A3
1 of 14
No
No
2  
Hsap\SLC2A9
1 of 14
No
No
Hsap\SLC2A11
1 of 14
No
No
Hsap\SLC2A12
1 of 14
No
No
Hsap\SLC2A13
1 of 14
No
No
Hsap\SV2A
1 of 14
No
No
Hsap\SV2B
1 of 14
No
No
Hsap\SV2C
1 of 14
No
No
Hsap\SVOP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (30)
Rnor\Slc22a1
9 of 14
Yes
No
Rnor\Slc22a2
9 of 14
Yes
No
Rnor\Slc22a3
9 of 14
Yes
No
Rnor\Slc22a5
8 of 14
No
No
Rnor\Slc22a22
7 of 14
No
Yes
Rnor\LOC685081
6 of 14
No
No
Rnor\Slc22a4
6 of 14
No
No
Rnor\Slc22a6
6 of 14
No
No
Rnor\Slc22a7
6 of 14
No
No
Rnor\Slc22a8
6 of 14
No
Yes
Rnor\Slc22a12
6 of 14
No
No
Rnor\Slc22a13
6 of 14
No
No
Rnor\Slc22a15
6 of 14
No
Yes
Rnor\Slc22a14
5 of 14
No
Yes
Rnor\Slc22a20
5 of 14
No
Yes
Rnor\Slc22a25
5 of 14
No
Yes
Rnor\UST4r
5 of 14
No
Yes
Rnor\Ust5r
5 of 14
No
Yes
Rnor\Slc22a23
4 of 14
No
Yes
Rnor\Slc22a17
3 of 14
No
Yes
Rnor\Svopl
2 of 14
No
No
Rnor\Hiat1-ps1
1 of 14
No
No
Rnor\LOC303140
1 of 14
No
Yes
Rnor\Mfsd9
1 of 14
No
No
Rnor\Mfsd14a
1 of 14
No
No
Rnor\Slc22a16
1 of 14
No
Yes
Rnor\Sv2a
1 of 14
No
No
Rnor\Sv2b
1 of 14
No
No
Rnor\Sv2c
1 of 14
No
No
Rnor\Svop
1 of 14
No
No
Mus musculus (laboratory mouse) (31)
Mmus\Slc22a21
11 of 14
Yes
Yes
Mmus\Slc22a4
10 of 14
No
Yes
Mmus\Slc22a5
10 of 14
No
Yes
Mmus\Slc22a1
8 of 14
No
Yes
Mmus\Slc22a2
8 of 14
No
Yes
Mmus\Slc22a3
8 of 14
No
Yes
Mmus\Slc22a13
7 of 14
No
No
Mmus\Slc22a14
7 of 14
No
Yes
Mmus\Slc22a22
7 of 14
No
Yes
Mmus\Slc22a6
6 of 14
No
No
Mmus\Slc22a7
6 of 14
No
No
Mmus\Slc22a8
6 of 14
No
No
Mmus\Slc22a12
6 of 14
No
No
Mmus\Slc22a20
6 of 14
No
No
Mmus\Slc22a16
5 of 14
No
No
Mmus\Slc22a19
5 of 14
No
Yes
Mmus\Slc22a26
5 of 14
No
Yes
Mmus\Slc22a27
5 of 14
No
No
Mmus\Slc22a28
5 of 14
No
No
Mmus\Slc22a29
5 of 14
No
No
Mmus\Slc22a30
5 of 14
No
No
Mmus\Slc22a15
4 of 14
No
No
Mmus\Slc22a23
4 of 14
No
Yes
Mmus\Slc22a17
3 of 14
No
Yes
Mmus\Svopl
2 of 14
No
No
Mmus\Mfsd14a
1 of 14
No
No
Mmus\Slc22a13b
1 of 14
No
Yes
Mmus\Sv2a
1 of 14
No
No
Mmus\Sv2b
1 of 14
No
No
Mmus\Sv2c
1 of 14
No
No
Mmus\Svop
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (34)
Xtro\slc22a13
6 of 13
Yes
Yes
Xtro\slc22a4
5 of 13
No
Yes
Xtro\slc22a5
5 of 13
No
Yes
Xtro\slc22a2
4 of 13
No
Yes
Xtro\slc22a6
4 of 13
No
Yes
Xtro\slc22a8l.1
4 of 13
No
No
Xtro\slc22a8
4 of 13
No
Yes
Xtro\slc22a15.1
4 of 13
No
No
Xtro\slc22a15.2
4 of 13
No
No
Xtro\slc22a20p.1
4 of 13
No
Yes
Xtro\LOC100490946
3 of 13
No
Yes
Xtro\slc22a16
3 of 13
No
Yes
Xtro\slc22a23
3 of 13
No
Yes
Xtro\LOC116411083
2 of 13
No
No
Xtro\slc22a31
2 of 13
No
Yes
Xtro\arhgap25
1 of 13
No
Yes
Xtro\b3galnt2
1 of 13
No
No
Xtro\bfar
1 of 13
No
No
Xtro\cd99
1 of 13
No
Yes
Xtro\gmnn
1 of 13
No
No
Xtro\krt70
1 of 13
No
Yes
Xtro\mfsd9
1 of 13
No
No
Xtro\mfsd10
1 of 13
No
No
Xtro\nectin2
1 of 13
No
Yes
Xtro\pabir2
1 of 13
No
No
Xtro\slc2a5
1 of 13
No
No
Xtro\slc2a6
1 of 13
No
No
Xtro\slc2a7
1 of 13
No
No
Xtro\slc2a11l2
1 of 13
No
No
Xtro\sv2a
1 of 13
No
No
Xtro\sv2b
1 of 13
No
No
Xtro\svopl
1 of 13
No
No
Xtro\tmem65
1 of 13
No
No
Xtro\ttc9b
1 of 13
No
No
Danio rerio (Zebrafish) (33)
Drer\si:dkey-166k12.1
10 of 14
Yes
Yes
Drer\si:dkey-119m7.4
9 of 14
No
Yes
Drer\slc22a13b
9 of 14
No
Yes
Drer\oct2
8 of 14
No
Yes
Drer\slc22a2
8 of 14
No
Yes
Drer\slc22a7b.2
7 of 14
No
Yes
Drer\slc22a7b.3
7 of 14
No
Yes
Drer\slc22a4
6 of 14
No
No
Drer\slc22a5
6 of 14
No
No
Drer\slc22a6l
6 of 14
No
Yes
Drer\slc22a7a
6 of 14
No
No
Drer\slc22a7b.1
6 of 14
No
Yes
Drer\slc22a13a
6 of 14
No
Yes
Drer\slc22a21
6 of 14
No
No
Drer\oatx
5 of 14
No
No
Drer\slc22a15
5 of 14
No
Yes
Drer\slc22a16
5 of 14
No
No
Drer\LOC566640
4 of 14
No
Yes
Drer\slc22a23
4 of 14
No
Yes
Drer\si:dkey-190l8.2
3 of 14
No
Yes
Drer\zmp:0000001102
3 of 14
No
No
Drer\svopl
2 of 14
No
No
Drer\mfsd10
1 of 14
No
No
Drer\mfsd14a1
1 of 14
No
No
Drer\slc2a10
1 of 14
No
No
Drer\slc22a31
1 of 14
No
Yes
Drer\sv2a
1 of 14
No
No
Drer\sv2ba
1 of 14
No
No
Drer\sv2bb
1 of 14
No
No
Drer\sv2ca
1 of 14
No
No
Drer\sv2
1 of 14
No
No
Drer\svopa
1 of 14
No
No
Drer\svopb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (36)
Cele\F45E10.2
10 of 14
Yes
Yes
Cele\Y82E9BR.16
10 of 14
Yes
Yes
Cele\C06H5.6
6 of 14
No
Yes
Cele\str-176
6 of 14
No
Yes
Cele\B0252.3
5 of 14
No
Yes
Cele\B0361.11
5 of 14
No
Yes
Cele\C46C2.2
5 of 14
No
Yes
Cele\F17C11.12
5 of 14
No
Yes
Cele\F23F12.3
5 of 14
No
Yes
Cele\K05F1.6
5 of 14
No
Yes
Cele\oat-1
5 of 14
No
No
Cele\oct-2
5 of 14
No
No
Cele\Y66D12A.13
5 of 14
No
Yes
Cele\C44C10.3
4 of 14
No
No
Cele\F23F12.13
4 of 14
No
No
Cele\F32H5.4
4 of 14
No
Yes
Cele\K11D9.3
4 of 14
No
Yes
Cele\oct-1
4 of 14
No
No
Cele\T05A1.5
4 of 14
No
Yes
Cele\T12B3.2
4 of 14
No
Yes
Cele\T22F7.1
4 of 14
No
No
Cele\Y51A2D.18
4 of 14
No
Yes
Cele\K09E9.1
3 of 14
No
Yes
Cele\pes-23
3 of 14
No
Yes
Cele\ZK892.3
3 of 14
No
Yes
Cele\suex-2
2 of 14
No
No
Cele\T08B1.1
2 of 14
No
Yes
Cele\Y57G11C.23
2 of 14
No
Yes
Cele\C35A11.4
1 of 14
No
No
Cele\fgt-1
1 of 14
No
No
Cele\hmit-1.1
1 of 14
No
No
Cele\hmit-1.2
1 of 14
No
No
Cele\K09C4.4
1 of 14
No
No
Cele\mfsd-10
1 of 14
No
No
Cele\R09B5.11
1 of 14
No
No
Cele\svop-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (36)
Agam\AgaP_AGAP004309
12 of 12
Yes
Yes
Agam\AgaP_AGAP003039
6 of 12
No
No
Agam\AgaP_AGAP003038
4 of 12
No
No
Agam\AgaP_AGAP003303
4 of 12
No
No
Agam\AgaP_AGAP005530
4 of 12
No
No
Agam\AgaP_AGAP006609
4 of 12
No
No
Agam\AgaP_AGAP008335
4 of 12
No
No
Agam\AgaP_AGAP010509
4 of 12
No
No
Agam\AgaP_AGAP013029
4 of 12
No
No
Agam\AgaP_AGAP001202
3 of 12
No
No
Agam\AgaP_AGAP004104
3 of 12
No
No
Agam\AgaP_AGAP004107
3 of 12
No
No
Agam\AgaP_AGAP012383
3 of 12
No
No
Agam\AgaP_AGAP004457
2 of 12
No
No
Agam\AgaP_AGAP000128
1 of 12
No
No
Agam\AgaP_AGAP000732
1 of 12
No
No
Agam\AgaP_AGAP000785
1 of 12
No
No
Agam\AgaP_AGAP001160
1 of 12
No
No
Agam\AgaP_AGAP001391
1 of 12
No
No
Agam\AgaP_AGAP002826
1 of 12
No
No
Agam\AgaP_AGAP003495
1 of 12
No
No
Agam\AgaP_AGAP004156
1 of 12
No
No
Agam\AgaP_AGAP004157
1 of 12
No
No
Agam\AgaP_AGAP004350
1 of 12
No
No
Agam\AgaP_AGAP005600
1 of 12
No
No
Agam\AgaP_AGAP007660
1 of 12
No
No
Agam\AgaP_AGAP007667
1 of 12
No
No
Agam\AgaP_AGAP007856
1 of 12
No
No
Agam\AgaP_AGAP008721
1 of 12
No
No
Agam\AgaP_AGAP008900
1 of 12
No
No
Agam\AgaP_AGAP009745
1 of 12
No
No
Agam\AgaP_AGAP010892
1 of 12
No
No
Agam\AgaP_AGAP011680
1 of 12
No
No
Agam\AgaP_AGAP012218
1 of 12
No
No
Agam\AgaP_AGAP012761
1 of 12
No
No
Agam\AgaP_AGAP013063
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (57)
Atha\OCT4
10 of 13
Yes
Yes
Atha\OCT3
7 of 13
No
No
Atha\OCT1
6 of 13
No
Yes
Atha\OCT2
6 of 13
No
No
Atha\OCT5
5 of 13
No
Yes
Atha\OCT6
4 of 13
No
No
Atha\AT4G08878
2 of 13
No
Yes
Atha\PHT1;1
2 of 13
No
Yes
Atha\PHT1;2
2 of 13
No
Yes
Atha\PHT1;3
2 of 13
No
Yes
Atha\PHT1;4
2 of 13
No
Yes
Atha\PHT1;5
2 of 13
No
Yes
Atha\PHT1;6
2 of 13
No
No
Atha\PHT1;7
2 of 13
No
Yes
Atha\PHT1;8
2 of 13
No
Yes
Atha\PHT1;9
2 of 13
No
Yes
Atha\AT1G05030
1 of 13
No
No
Atha\AT1G19450
1 of 13
No
No
Atha\AT1G54730
1 of 13
No
No
Atha\AT1G67300
1 of 13
No
No
Atha\AT2G18480
1 of 13
No
No
Atha\AT2G20780
1 of 13
No
No
Atha\AT2G48020
1 of 13
No
No
Atha\AT3G05150
1 of 13
No
No
Atha\AT3G05155
1 of 13
No
No
Atha\AT3G05160
1 of 13
No
No
Atha\AT3G05165
1 of 13
No
No
Atha\AT3G19940
1 of 13
No
No
Atha\AT3G20460
1 of 13
No
No
Atha\AT4G04750
1 of 13
No
No
Atha\AT4G04760
1 of 13
No
No
Atha\AT4G08895
1 of 13
No
Yes
Atha\AT5G17010
1 of 13
No
No
Atha\AT5G18840
1 of 13
No
No
Atha\AT5G59250
1 of 13
No
No
Atha\ERD6
1 of 13
No
No
Atha\INT1
1 of 13
No
No
Atha\INT2
1 of 13
No
No
Atha\INT3
1 of 13
No
No
Atha\INT4
1 of 13
No
No
Atha\NiaP
1 of 13
No
No
Atha\PGLCT
1 of 13
No
No
Atha\PMT5
1 of 13
No
No
Atha\PMT6
1 of 13
No
No
Atha\SFP1
1 of 13
No
No
Atha\SFP2
1 of 13
No
No
Atha\SGB1
1 of 13
No
No
Atha\STP1
1 of 13
No
No
Atha\STP2
1 of 13
No
No
Atha\STP9
1 of 13
No
No
Atha\TMT1
1 of 13
No
No
Atha\TMT2
1 of 13
No
No
Atha\TMT3
1 of 13
No
No
Atha\VGT1
1 of 13
No
No
Atha\ZIF1
1 of 13
No
No
Atha\ZIFL1
1 of 13
No
No
Atha\ZIFL2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (31)
Scer\PHO84
3 of 13
Yes
Yes
Scer\GIT1
2 of 13
No
Yes
Scer\GAL2
1 of 13
No
No
Scer\HXT1
1 of 13
No
No
Scer\HXT2
1 of 13
No
No
Scer\HXT3
1 of 13
No
No
Scer\HXT4
1 of 13
No
No
Scer\HXT5
1 of 13
No
No
Scer\HXT6
1 of 13
No
No
Scer\HXT7
1 of 13
No
No
Scer\HXT8
1 of 13
No
No
Scer\HXT9
1 of 13
No
No
Scer\HXT10
1 of 13
No
No
Scer\HXT13
1 of 13
No
No
Scer\HXT14
1 of 13
No
No
Scer\HXT15
1 of 13
No
No
Scer\HXT16
1 of 13
No
No
Scer\HXT17
1 of 13
No
No
Scer\ITR1
1 of 13
No
No
Scer\ITR2
1 of 13
No
No
Scer\JEN1
1 of 13
No
Yes
Scer\MAL11
1 of 13
No
No
Scer\MAL31
1 of 13
No
No
Scer\MPH2
1 of 13
No
No
Scer\MPH3
1 of 13
No
No
Scer\RGT2
1 of 13
No
No
Scer\SNF3
1 of 13
No
No
Scer\TPO2
1 of 13
No
Yes
Scer\TPO3
1 of 13
No
No
Scer\VPS73
1 of 13
No
No
Scer\YCR023C
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (9)
Spom\SPAPB1E7.08c
3 of 12
Yes
No
Spom\SPAC23D3.12
2 of 12
No
Yes
Spom\SPBC8E4.01c
2 of 12
No
Yes
Spom\SPBC1271.09
2 of 12
No
Yes
Spom\SPBC1683.01
2 of 12
No
Yes
Spom\SPCC2H8.02
2 of 12
No
Yes
Spom\fnx1
1 of 12
No
Yes
Spom\fnx2
1 of 12
No
Yes
Spom\SPCC1529.01
1 of 12
No
Yes
Escherichia coli (enterobacterium) (16)
Ecol\ygcS
4 of 11
Yes
No
Ecol\yaaU
3 of 11
No
No
Ecol\ydjK
3 of 11
No
No
Ecol\proP
2 of 11
No
No
Ecol\ydjE
2 of 11
No
No
Ecol\kgtP
1 of 11
No
Yes
Ecol\mdfA
1 of 11
No
Yes
Ecol\mdtG
1 of 11
No
No
Ecol\mdtM
1 of 11
No
Yes
Ecol\mhpT
1 of 11
No
No
Ecol\nanT
1 of 11
No
No
Ecol\nanX
1 of 11
No
No
Ecol\shiA
1 of 11
No
No
Ecol\ydfJ
1 of 11
No
Yes
Ecol\yhjE
1 of 11
No
Yes
Ecol\ynfM
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Orct2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (46)
Orct
13 of 13
Balat
9 of 13
CG4630
9 of 13
CG8654
9 of 13
CarT
8 of 13
CG6126
8 of 13
CG6356
8 of 13
CG10486
8 of 13
CG42269
8 of 13
CG5592
7 of 13
CG6006
7 of 13
CG7458
7 of 13
CG8925
7 of 13
SLC22A
7 of 13
CG6231
6 of 13
CG7084
6 of 13
CG7342
6 of 13
CG14855
6 of 13
CG16727
6 of 13
CG17752
6 of 13
CG7333
5 of 13
CG14857
5 of 13
CG4459
4 of 13
CG4462
4 of 13
CG4465
4 of 13
CG14856
4 of 13
CG17751
4 of 13
CG44098
4 of 13
CG3690
3 of 13
CG4324
3 of 13
CG12783
3 of 13
CG14691
3 of 13
CG15221
3 of 13
CG31103
3 of 13
CG31106
3 of 13
CG31272
3 of 13
CG33233
3 of 13
CG33234
3 of 13
sv2
2 of 13
CG1213
1 of 13
CG6484
1 of 13
CG8249
1 of 13
CG15408
1 of 13
nebu
1 of 13
rtet
1 of 13
Tret1l
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Orct2EP1072
    exacerbates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Orct2EP3569
    ameliorates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC22A13; solute carrier family 22 member 13
    10 of 14
    604047
        SLC22A4; solute carrier family 22 member 4
        8 of 14
        604190
         
        SLC22A5; solute carrier family 22 member 5
        8 of 14
        603377
        SLC22A2; solute carrier family 22 member 2
        7 of 14
        602608
             
            SLC22A3; solute carrier family 22 member 3
            7 of 14
            604842
                SLC22A6; solute carrier family 22 member 6
                7 of 14
                607582
                    SLC22A1; solute carrier family 22 member 1
                    6 of 14
                    602607
                         
                        SLC22A7; solute carrier family 22 member 7
                        6 of 14
                        604995
                            SLC22A8; solute carrier family 22 member 8
                            6 of 14
                            607581
                                SLC22A11; solute carrier family 22 member 11
                                6 of 14
                                607097
                                    SLC22A12; solute carrier family 22 member 12
                                    6 of 14
                                    607096
                                      SLC22A14; solute carrier family 22 member 14
                                      6 of 14
                                      604048
                                          SLC22A16; solute carrier family 22 member 16
                                          6 of 14
                                          608276
                                               
                                              SLC22A9; solute carrier family 22 member 9
                                              5 of 14
                                              607579
                                                  SLC22A10; solute carrier family 22 member 10 (gene/pseudogene)
                                                  5 of 14
                                                  607580
                                                      SLC22A15; solute carrier family 22 member 15
                                                      5 of 14
                                                      608275
                                                          SLC22A20P; solute carrier family 22 member 20, pseudogene
                                                          5 of 14
                                                          611696
                                                              SLC22A24; solute carrier family 22 member 24
                                                              5 of 14
                                                              611698
                                                                  SLC22A25; solute carrier family 22 member 25
                                                                  5 of 14
                                                                  610792
                                                                      SLC22A23; solute carrier family 22 member 23
                                                                      4 of 14
                                                                      611697
                                                                          SLC22A17; solute carrier family 22 member 17
                                                                          3 of 14
                                                                          611461
                                                                              SLC22A31; solute carrier family 22 member 31
                                                                              3 of 14
                                                                                  Functional Complementation Data
                                                                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                                  Interactions
                                                                                  Summary of Physical Interactions
                                                                                  Interaction Browsers
                                                                                  Summary of Genetic Interactions
                                                                                  Interaction Browsers
                                                                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                                  Please look at the allele data for full details of the genetic interactions
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  pnr
                                                                                  suppressible
                                                                                  Orct2
                                                                                  (Pena-Rangel et al., 2002)
                                                                                  External Data
                                                                                  Linkouts
                                                                                  BioGRID - A database of protein and genetic interactions.
                                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                                  Pathways
                                                                                  Signaling Pathways (FlyBase)
                                                                                  Metabolic Pathways
                                                                                  FlyBase
                                                                                  External Links
                                                                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                                                  External Data
                                                                                  Class of Gene
                                                                                  Genomic Location and Detailed Mapping Data
                                                                                  Chromosome (arm)
                                                                                  3R
                                                                                  Recombination map
                                                                                  3-84
                                                                                  Cytogenetic map
                                                                                  95F8-95F8
                                                                                  Sequence location
                                                                                  FlyBase Computed Cytological Location
                                                                                  Cytogenetic map
                                                                                  Evidence for location
                                                                                  95F8-95F8
                                                                                  Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
                                                                                  Experimentally Determined Cytological Location
                                                                                  Cytogenetic map
                                                                                  Notes
                                                                                  References
                                                                                  Experimentally Determined Recombination Data
                                                                                  Location

                                                                                  3-84

                                                                                  (FlyBase, 2016)

                                                                                  3-82.9

                                                                                  (Comeron et al., 2012)
                                                                                  Left of (cM)
                                                                                  Right of (cM)
                                                                                  Notes
                                                                                  Stocks and Reagents
                                                                                  Stocks (6)
                                                                                  Genomic Clones (17)
                                                                                   

                                                                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                                  cDNA Clones (39)
                                                                                   

                                                                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                                  cDNA clones, fully sequenced
                                                                                  BDGP DGC clones
                                                                                  Other clones
                                                                                    Drosophila Genomics Resource Center cDNA clones

                                                                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                                    cDNA Clones, End Sequenced (ESTs)
                                                                                    BDGP DGC clones
                                                                                    Other clones
                                                                                    RNAi and Array Information
                                                                                    Linkouts
                                                                                    DRSC - Results frm RNAi screens
                                                                                    Antibody Information
                                                                                    Laboratory Generated Antibodies
                                                                                     
                                                                                    Commercially Available Antibodies
                                                                                     
                                                                                    Cell Line Information
                                                                                    Publicly Available Cell Lines
                                                                                     
                                                                                      Other Stable Cell Lines
                                                                                       
                                                                                        Other Comments

                                                                                        The InR pathway regulates Orct2 expression.

                                                                                        (Herranz et al., 2006)

                                                                                        Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Showed cycling in Canton S and low expression in Clk mutants in microarray experiments. Identified in S2/cycloheximide assay as a direct target of Clk mediated transcriptional regulation.

                                                                                        (McDonald and Rosbash, 2001)
                                                                                        Relationship to Other Genes
                                                                                        Source for database merge of

                                                                                        Source for merge of: Orct2 CG13610

                                                                                        (Shirras, 2005.5.31)

                                                                                        Source for merge of: Orct2 EP1072

                                                                                        (Herranz et al., 2006)
                                                                                        Additional comments

                                                                                        FlyBase curator comment: "EP1072" phenotype of modifying the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is stated to be due to its effect on Orct2 but orientation of the P{EP} element suggests otherwise.

                                                                                        (Shulman and Feany, 2003)
                                                                                        Nomenclature History
                                                                                        Source for database identify of
                                                                                        Nomenclature comments
                                                                                        Etymology

                                                                                        The embryonic expression pattern of the gene resembles a "calderon", the Spanish name for the symbol that increases the length of a musical note, hence the name.

                                                                                        (Herranz et al., 2006)
                                                                                        Synonyms and Secondary IDs (8)
                                                                                        Datasets (0)
                                                                                        Study focus (0)
                                                                                        Experimental Role
                                                                                        Project
                                                                                        Project Type
                                                                                        Title
                                                                                        Study result (0)
                                                                                        Result
                                                                                        Result Type
                                                                                        Title
                                                                                        External Crossreferences and Linkouts ( 50 )
                                                                                        Sequence Crossreferences
                                                                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                                        Other crossreferences
                                                                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                        FlyMine - An integrated database for Drosophila genomics
                                                                                        InterPro - A database of protein families, domains and functional sites
                                                                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                        Linkouts
                                                                                        BioGRID - A database of protein and genetic interactions.
                                                                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                        DroID - A comprehensive database of gene and protein interactions.
                                                                                        DRSC - Results frm RNAi screens
                                                                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                        Flygut - An atlas of the Drosophila adult midgut
                                                                                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                                                        References (60)