FlyBase Gene Report: Dmel\RFeSP

General Information

Symbol

Dmel\RFeSP

Species

D. melanogaster

Name

Rieske iron-sulfur protein

Annotation Symbol

CG7361

Feature Type

protein_coding_gene

FlyBase ID

FBgn0021906

Gene Model Status

Current

Stock Availability

37 publicly available

Enzyme Name (EC)

quinol--cytochrome-c reductase (7.1.1.8)

Gene Summary

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a (UniProt, Q9VQ29)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(2)k11704, Rieske

Key Links

Genomic Location

Cytogenetic map

22A3-22A3

Sequence location

2L:1,612,429..1,614,160 [-]

Recombination map

2-3

RefSeq locus

NT_033779 REGION:1612429..1614160

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables 2 iron, 2 sulfur cluster binding

inferred from electronic annotation with InterPro:IPR005805, InterPro:IPR014349, InterPro:IPR017941, InterPro:IPR036922

(InterPro Project Members, 2004-)

enables oxidoreductase activity

inferred from biological aspect of ancestor with PANTHER:PTN000015358

(GO Reference Genome Project, 2011-)

enables quinol-cytochrome-c reductase activity

inferred from sequence or structural similarity with UniProtKB:P08067

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR004192, InterPro:IPR006317, InterPro:IPR037008

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitochondrial electron transport, ubiquinol to cytochrome c

inferred from biological aspect of ancestor with PANTHER:PTN000015359

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P08067

(Gene Ontology Curators, 2002-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from direct assay

(Gontijo et al., 2011)

located_in mitochondrion

inferred from high throughput direct assay

(Alonso et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR005805

(InterPro Project Members, 2004-)

is_active_in mitochondrial inner membrane

inferred from sequence or structural similarity with UniProtKB:P08067

(Gene Ontology Curators, 2002-)

part_of respiratory chain complex III

inferred from biological aspect of ancestor with PANTHER:PTN000015359

(GO Reference Genome Project, 2011-)

non-traceable author statement

(Porcelli et al., 2007, Tripoli et al., 2005)

inferred from sequence or structural similarity with UniProtKB:P08067

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX III - CORE SUBUNITS

MITOCHONDRIAL COMPLEX III - TESTIS-SPECIFIC VARIANT

MITOCHONDRIAL COMPLEX III

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION

Protein Family (UniProt)

Belongs to the Rieske iron-sulfur protein family. (Q9VQ29)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

quinol-cytochrome-c reductase activity

a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)- [cytochrome c](out) + 2 H(+)(out) (7.1.1.8)

RHEA 11484:

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX III - CORE SUBUNITS -: Mitochondrial complex III - core subunits are ubiquinol-cytochrome c reductases that act to catalyze the electron transfer reaction from the lipophilic substrate ubiquinol (QH2) to cytochrome C (cyt c), coupled with proton translocation across the membrane. As a result, for every QH2 molecule oxidized, four protons are transferred from the mitochondrial matrix to the intermembrane space and two molecules of cyt c are reduced. The subunit composition of complex III varies between species, though all complexes contain three redox subunits that form the catalytic core: cyt b; cyt c1; and the iron sulfur (Rieske) protein (ISP). (Adapted from PMID:23201476 and PMID: 23871937.)
MITOCHONDRIAL COMPLEX III - TESTIS-SPECIFIC VARIANT -: Mitochondrial complex III catalyzes the electron transfer reaction from the lipophilic substrate ubiquinol (QH2) to cytochrome C (cyt c), coupled with proton translocation across the membrane. As a result, for every QH2 molecule oxidized, four protons are transferred from the mitochondrial matrix to the intermembrane space and two molecules of cyt c are reduced. (Adapted from PMID:23201476 and PMID: 23871937.)
MITOCHONDRIAL COMPLEX III -: Mitochondrial complex III catalyzes the electron transfer reaction from the lipophilic substrate ubiquinol (QH2) to cytochrome C (cyt c), coupled with proton translocation across the membrane. As a result, for every QH2 molecule oxidized, four protons are transferred from the mitochondrial matrix to the intermembrane space and two molecules of cyt c are reduced. (Adapted from PMID:23201476 and PMID: 23871937.)

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION -: Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)

Protein Function (UniProtKB)

(UniProt, Q9VQ29)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RFeSP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VQ29)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.42

Gene model reviewed during 5.47

Strain-specific isoform not annotated: a small deletion within intron 2 results in inefficient splicing of this intron; specific to Canton-S and mutant strains derived from Canton-S, including the sequenced strain. The unspliced isoform encodes an atypical protein that lacks an iron-sulphur domain and localizes to mitochondria; previously annotated as RFeSP-RA. (FBrf0213743)

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RFeSP-RB

FBtr0077915

NM_164426

851

230

RFeSP-RD

FBtr0334842

NM_001272947

1118

230

RFeSP-RE

FBtr0334843

NM_080009

1000

230

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RFeSP-PB

FBpp0077581

24.9

230

8.89

FBpp0306867

24.9

230

8.89

FBpp0306868

24.9

230

8.89

Q9VQ29

NP_524748

AAF51353

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

230 aa isoforms: RFeSP-PB, RFeSP-PD, RFeSP-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with sloth1; the interaction is probably involved in the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex.

(UniProt, Q9VQ29)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VQ29

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RFeSP using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.60

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

third instar larval stage

larval central nervous system | ubiquitous

(Kim and Marqués, 2010)

larval brain

(Kim and Marqués, 2010)

ring gland

(Kim and Marqués, 2010)

imaginal disc

(Kim and Marqués, 2010)

gonad

(Kim and Marqués, 2010)

embryonic/larval gut

(Kim and Marqués, 2010)

embryonic/larval Malpighian tubule

(Kim and Marqués, 2010)

embryonic/larval salivary gland

(Kim and Marqués, 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in mitochondrion

inferred from direct assay

(Gontijo et al., 2011)

located_in mitochondrion

inferred from high throughput direct assay

(Alonso et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RFeSP in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RFeSP

View exonic expression by tissue for Dmel\RFeSP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0021906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44390/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0021906

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0021906

Flygut - An atlas of the Drosophila adult midgut

FBgn0021906

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\RFeSP

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RFeSP

Transgenic constructs containing regulatory region of RFeSP

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2L)ast1

(BDGP Project Members, 1994-1999)

Df(2L)ast2

(Spradling et al., 1999)

Df(2L)dp-79b

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)Exel6005

(Ryder, 2004.4.26)

Df(2L)S2

(Welte, 2000.2.23)

Gene not disrupted in

Df(2L)S3

(Welte, 2000.2.23)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Phenotype manifest in

Allele

lysosome & larval fat body | somatic clone | cell autonomous

RFeSP^k11704

lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4^Act5C.PP

RFeSP^NIG.7361R

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\UQCRFS1

13 of 14

Yes

Hsap\UQCRFS1P1

9 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Uqcrfs1

13 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Uqcrfs1

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\uqcrfs1

7 of 13

Yes

Xtro\lck

5 of 13

Yes

Xtro\atp5pb

1 of 13

Danio rerio (Zebrafish) (1)

Drer\uqcrfs1

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\isp-1

13 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP008955

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT5G13430

11 of 13

Yes

Atha\AT5G13440

11 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\RIP1

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rip1

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RFeSP. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

13 of 14

191327

MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 10; MC3DN10

UQCRFS1P1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1

9 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

RFeSP - smg

anti bait coimmunoprecipitation, primer specific pcr

(Chartier et al., 2015)

protein-protein

Physical Interaction

Assay

References

RFeSP - Cyt-c1

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - Egfr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RFeSP - UQCR-11

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - UQCR-14

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - UQCR-C1

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - UQCR-C2

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - UQCR-Q

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - ox

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

RFeSP - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RFeSP - sloth1

anti tag coimmunoprecipitation, anti tag western blot

(Bosch et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with sloth1; the interaction is probably involved in the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex.

(UniProt, Q9VQ29 )

Linkouts

BioGRID - A database of protein and genetic interactions.

69024

DroID - A comprehensive database of gene and protein interactions.

FBgn0021906

MIST (protein-protein) - An integrated Molecular Interaction Database

44390

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

OXIDATIVE PHOSPHORYLATION

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-3

Cytogenetic map

22A3-22A3

Sequence location

2L:1,612,429..1,614,160 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22A3-22A3

Limits computationally determined from genome sequence between P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619 and P{lacW}RFeSP^k11704

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

22A3-22A4

(determined by in situ hybridisation)

(Spradling et al., 1999)

22A3-22A4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-3

(FlyBase, 2016)

2-2.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (37)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12022

P{VT000812-GAL4}attP2

12563

P{VT000816-GAL4}attP2

13346

P{VT000809-GAL4}attP2

13347

P{VT000811-GAL4}attP2

13640

P{VT000817-GAL4}attP2

14967

P{VT000810-GAL4}attP2

13913

P{VT000812-lexA}JK22C

15687

P{VT000810-lexA}attP40

7361R-1

7361R-3

v330481

v330703

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (178)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD14047

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0021906

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0021906

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: RFeSP CG7361

(Misra, 2000.8.9)

Source for merge of: RFeSP anon- EST:Posey219

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG7361

(Delamotte et al., 2025, Curcio et al., 2024, Müller-Eigner et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Meadows, 2018.4.4, Meadows, 2018.10.31, Çiçek et al., 2016, Rosa-Ferreira et al., 2015, Walls et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Kim and Marqués, 2010, Tiefenböck et al., 2010, Baltzer et al., 2009, Hughes et al., 2008, Porcelli et al., 2007, Caggese et al., 2006, Robertson, 2001.7.7)

(Welte, 2000.2.23)

Noble

(Gontijo et al., 2011)

Q9VQ29

(Ebanks et al., 2021)

RISP

(Arsham and Neufeld, 2009)

RfeSP

(Alonso et al., 2005, Halfon et al., 2002)

Rieske

(Müller-Eigner et al., 2024, Garreau-Balandier et al., 2014)

UCRI

(Caggese et al., 2006)

UQCR-RFeSP

(Porcelli and Marygold, 2014.9.16)

anon-EST:Posey219

dUQCRFS1

(Bosch et al., 2022)

l(2)k11704

(Gelbart, 1999.7.20, BDGP Project Members, 1994-1999)

Name Synonyms

Complex III

(Monteiro et al., 2023)

Not out of the blue

(Gontijo et al., 2011)

RIESKE IRON-SULFUR PROTEIN

(Alonso et al., 2005)

Rieske Iron-Sulfur Protein

(Kim and Marqués, 2010)

Rieske iron sulfur protein

(Porcelli and Marygold, 2014.9.16, Arsham and Neufeld, 2009)

Rieske iron sulphur protein

(Gontijo et al., 2011)

Rieske iron- sulfur protein of complex III

(Tiefenböck et al., 2010)

Rieske iron-sulfur protein

(Jaspers et al., 2012, Cammarato et al., 2011, Spradling et al., 1999)

Ubiquinol-cytochrome C reductase iron-sulfur subunit

(Caggese et al., 2006)

Ubiquinol-cytochrome c oxidoreductase Iron-sulfur

(Porcelli et al., 2007)

Ubiquinol-cytochrome c reductase Iron-sulfur subunit

(Tripoli et al., 2005)

Ubiquinol-cytochrome c reductase Rieske iron sulfur protein

(Porcelli and Marygold, 2014.9.16)

Secondary FlyBase IDs

FBgn0025542
FBgn0031352

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44390

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VQ29

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VQ29

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VQ29

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0021906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44390/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0021906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0021906

FlyMine - An integrated database for Drosophila genomics

FBgn0021906

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7361

MARRVEL_MODEL - MARRVEL (model organism gene)

44390

Linkouts

BioGRID - A database of protein and genetic interactions.

69024

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0021906

DroID - A comprehensive database of gene and protein interactions.

FBgn0021906

DRSC - Results frm RNAi screens

FBgn0021906

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021906

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0021906

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Flygut - An atlas of the Drosophila adult midgut

FBgn0021906

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0021906

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

44390

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

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