FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\ari-2
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General Information
Symbol
Dmel\ari-2
Species
D. melanogaster
Name
ariadne 2
Annotation Symbol
CG5709
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025186
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. (UniProt, O76924)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ari2, l(2)07768

Key Links
Genomic Location
Cytogenetic map
58D1-58D2
Sequence location
Recombination map
2-99
RefSeq locus
NT_033778 REGION:22212835..22217264
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ubiquitin conjugating enzyme binding
inferred from biological aspect of ancestor with PANTHER:PTN000188395
(GO Reference Genome Project, 2011-)
enables ubiquitin protein ligase activity
inferred from sequence or structural similarity with UniProtKB:Q9Y4X5
(Gene Ontology Curators, 2002-)
enables ubiquitin-protein transferase activity
inferred from electronic annotation with InterPro:IPR031127
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:O95376
(Gene Ontology Curators, 2002-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
inferred from electronic annotation with InterPro:IPR002867, InterPro:IPR047555, InterPro:IPR047556
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in protein polyubiquitination
inferred from sequence or structural similarity with UniProtKB:O95376
(Gene Ontology Curators, 2002-)
involved_in protein ubiquitination
inferred from electronic annotation with InterPro:IPR031127
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of ubiquitin ligase complex
inferred from biological aspect of ancestor with PANTHER:PTN000188395
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the RBR family. Ariadne subfamily. (O76924)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RING-BETWEEN-RING UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. RING-between-RING (RBR) E3 ligases are characterised by three closely spaced domains: RING1 (a classical RING finger domain), a In-Betweeen-RING (IBR) domain and a RING2 domain. The mechanism of action is described as RING/HECT-like, with the RING1 domain facilitating E2-transfer (E3 RING-like) to form a thioester intermediate with a cysteine in RING2 which then modifies the substrate protein (HECT-like). (Adapted from PMID:24469331).
Protein Function (UniProtKB)
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
(UniProt, O76924)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ari-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76924)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ari-2-RA
FBtr0071774
NM_058026
3008
509
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ari-2-PA
FBpp0071688
58.6
509
5.38
O76924
NP_477374
AAF46823
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Ubc10 (PubMed:10880484). Interacts with park (PubMed:29689197). Interacts with ari-1 (PubMed:29689197).

(UniProt, O76924)
Domain

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.

(UniProt, O76924)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ari-2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ari-2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ari-2
Transgenic constructs containing regulatory region of ari-2
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
Hsap\ARIH2
14 of 14
Yes
Yes
Hsap\ARIH1
5 of 14
No
No
4  
Hsap\ANKIB1
2 of 14
No
No
Hsap\CUL9
2 of 14
No
No
Hsap\RNF31
2 of 14
No
No
Hsap\RNF216
2 of 14
No
Yes
Hsap\CUL7
1 of 14
No
Yes
Hsap\PRKN
1 of 14
No
No
12  
Hsap\RBCK1
1 of 14
No
No
Hsap\RNF14
1 of 14
No
Yes
Hsap\RNF19A
1 of 14
No
No
Hsap\RNF19B
1 of 14
No
No
Hsap\RNF144A
1 of 14
No
No
Hsap\RNF144B
1 of 14
No
No
Hsap\RNF217
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Arih2
14 of 14
Yes
Yes
Rnor\Arih1
5 of 14
No
No
Rnor\Ankib1
2 of 14
No
No
Rnor\Cul9
2 of 14
No
No
Rnor\Rnf31
2 of 14
No
No
Rnor\Cul7
1 of 14
No
Yes
Rnor\Prkn
1 of 14
No
No
Rnor\Rbck1
1 of 14
No
Yes
Rnor\Rnf14
1 of 14
No
Yes
Rnor\Rnf19a
1 of 14
No
No
Rnor\Rnf19b
1 of 14
No
No
Rnor\Rnf144a
1 of 14
No
No
Rnor\Rnf144b
1 of 14
No
No
Rnor\Rnf216
1 of 14
No
No
Rnor\Rnf217
1 of 14
No
No
Mus musculus (laboratory mouse) (14)
Mmus\Arih2
14 of 14
Yes
Yes
Mmus\Arih1
5 of 14
No
No
Mmus\Cul9
2 of 14
No
No
Mmus\Rnf31
2 of 14
No
No
Mmus\Ankib1
1 of 14
No
No
Mmus\Cul7
1 of 14
No
Yes
Mmus\Prkn
1 of 14
No
No
Mmus\Rnf14
1 of 14
No
Yes
Mmus\Rnf19a
1 of 14
No
No
Mmus\Rnf19b
1 of 14
No
No
Mmus\Rnf144a
1 of 14
No
No
Mmus\Rnf144b
1 of 14
No
No
Mmus\Rnf216
1 of 14
No
No
Mmus\Rnf217
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\arih2
8 of 13
Yes
Yes
Xtro\arih1
5 of 13
No
No
Xtro\ankib1
1 of 13
No
No
Xtro\cul9
1 of 13
No
Yes
Xtro\LOC108645237
1 of 13
No
Yes
Xtro\rbck1
1 of 13
No
Yes
Xtro\rnf14.2
1 of 13
No
Yes
Xtro\rnf14.5
1 of 13
No
Yes
Xtro\rnf19b
1 of 13
No
Yes
Xtro\rnf31
1 of 13
No
No
Xtro\rnf144a
1 of 13
No
No
Xtro\rnf144b
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\arih2
14 of 14
Yes
Yes
Drer\arih1
5 of 14
No
No
Drer\arih1l
5 of 14
No
No
Drer\ankib1a
2 of 14
No
No
Drer\ankib1b
2 of 14
No
No
Drer\LOC100334178
2 of 14
No
No
Drer\rnf216
2 of 14
No
Yes
Drer\cul9
1 of 14
No
Yes
Drer\LOC558876
1 of 14
No
Yes
Drer\LOC794117
1 of 14
No
Yes
Drer\LOC108179742
1 of 14
No
No
Drer\LOC110437942
1 of 14
No
Yes
Drer\prkn
1 of 14
No
No
Drer\rnf14
1 of 14
No
Yes
Drer\rnf19a
1 of 14
No
No
Drer\rnf19b
1 of 14
No
No
Drer\rnf144aa
1 of 14
No
No
Drer\rnf144ab
1 of 14
No
No
Drer\rnf144b
1 of 14
No
No
Drer\rnf217
1 of 14
No
No
Drer\si:ch211-278j3.3
1 of 14
No
No
Drer\si:dkey-181m9.8
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\ari-2
14 of 14
Yes
Yes
Cele\ari-1.1
5 of 14
No
No
Cele\ari-1.2
5 of 14
No
No
Cele\ari-1.3
5 of 14
No
No
Cele\ari-1.4
5 of 14
No
No
Cele\C17H11.4
3 of 14
No
No
Cele\Y57A10A.31
2 of 14
No
Yes
Cele\C17H11.6
1 of 14
No
No
Cele\F56D2.2
1 of 14
No
No
Cele\F56D2.5
1 of 14
No
Yes
Cele\pdr-1
1 of 14
No
No
Cele\T20F5.6
1 of 14
No
Yes
Cele\Y49F6B.9
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP005977
12 of 12
Yes
Yes
Agam\AgaP_AGAP010891
5 of 12
No
No
Agam\AgaP_AGAP007788
2 of 12
No
No
Agam\AgaP_AGAP004573
1 of 12
No
No
Agam\AgaP_AGAP005143
1 of 12
No
No
Agam\AgaP_AGAP006580
1 of 12
No
No
Agam\AgaP_AGAP009239
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (47)
Atha\ARI1
8 of 13
Yes
No
Atha\ARI2
8 of 13
Yes
No
Atha\ARI3
8 of 13
Yes
No
Atha\ARI4
8 of 13
Yes
No
Atha\ARI8
7 of 13
No
No
Atha\ARI11
7 of 13
No
No
Atha\ARI5
6 of 13
No
No
Atha\ARI7
6 of 13
No
No
Atha\ARI9
6 of 13
No
No
Atha\ARI10
6 of 13
No
No
Atha\ARI12
6 of 13
No
No
Atha\ARI6
5 of 13
No
No
Atha\ARI13
3 of 13
No
No
Atha\ARI14
3 of 13
No
No
Atha\ARI15
3 of 13
No
No
Atha\ARI16
3 of 13
No
No
Atha\AT2G19610
2 of 13
No
Yes
Atha\AT2G21420
2 of 13
No
Yes
Atha\AT2G25360
2 of 13
No
Yes
Atha\AT2G25370
2 of 13
No
Yes
Atha\AT2G26130
2 of 13
No
Yes
Atha\AT2G26135
2 of 13
No
Yes
Atha\AT3G14250
2 of 13
No
Yes
Atha\AT3G43180
2 of 13
No
Yes
Atha\AT3G43750
2 of 13
No
Yes
Atha\AT3G45460
2 of 13
No
Yes
Atha\AT3G45470
2 of 13
No
No
Atha\AT3G45480
2 of 13
No
Yes
Atha\AT3G45490
2 of 13
No
Yes
Atha\AT3G45500
2 of 13
No
Yes
Atha\AT3G45510
2 of 13
No
Yes
Atha\AT3G45540
2 of 13
No
Yes
Atha\AT3G45555
2 of 13
No
Yes
Atha\AT3G45560
2 of 13
No
Yes
Atha\AT3G45570
2 of 13
No
Yes
Atha\AT3G45580
2 of 13
No
Yes
Atha\AT3G53690
2 of 13
No
No
Atha\AT4G01020
2 of 13
No
Yes
Atha\AT4G19670
2 of 13
No
Yes
Atha\AT5G07640
2 of 13
No
Yes
Atha\AT5G10370
2 of 13
No
Yes
Atha\AT5G37560
2 of 13
No
Yes
Atha\AT5G60250
2 of 13
No
Yes
Atha\AT2G16520
1 of 13
No
Yes
Atha\AT2G22940
1 of 13
No
Yes
Atha\AT3G45525
1 of 13
No
Yes
Atha\NHL8
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\HEL1
8 of 13
Yes
No
Scer\ITT1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC328.02
5 of 12
Yes
No
Spom\itt1
1 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ari-2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
ari-1
9 of 13
CG12362
8 of 13
CG33144
3 of 13
park
3 of 13
LUBEL
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARIH2; ariadne RBR E3 ubiquitin protein ligase 2
    14 of 14
    605615
        ARIH1; ariadne RBR E3 ubiquitin protein ligase 1
        5 of 14
        ARIADNE RBR E3 UBIQUITIN PROTEIN LIGASE 1; ARIH1
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Subunit Structure (UniProtKB)
            Interacts with Ubc10 (PubMed:10880484). Interacts with park (PubMed:29689197). Interacts with ari-1 (PubMed:29689197).
            (UniProt, O76924 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-99
            Cytogenetic map
            58D1-58D2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            58D1-58D2
            Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            58C-58D
            (Aguilera, 1998.8.18)
            58D1-58D2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            58D1-58D2
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-99

            (FlyBase, 2016)

            2-104.1

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (11)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (33)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: ari2 l(2)07768

                  (Spradling et al., 1999)
                  Additional comments
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: ari-2 CG5709

                  (Milshina, 1999.11)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (8)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 48 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (48)