FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Atxn7
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General Information
Symbol
Dmel\Atxn7
Species
D. melanogaster
Name
Ataxin 7
Annotation Symbol
CG9866
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031420
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
22E1-22E1
Sequence location
Recombination map
2-6
RefSeq locus
NT_033779 REGION:2375841..2380506
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in SAGA complex assembly
inferred from mutant phenotype
(Mohan et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Weake et al., 2011)
located_in polytene chromosome
inferred from direct assay
(Mohan et al., 2014)
part_of SAGA complex
inferred from direct assay
(Mohan et al., 2014, Weake et al., 2011)
part_of SAGA-type complex
inferred from direct assay
(Weake et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ataxin-7 family. (Q9VQB6)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
SAGA COMPLEX -
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
Protein Function (UniProtKB)
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:20008933, PubMed:21764853, PubMed:24493646, PubMed:30559249). Acts as a tether connecting the not/nonstop-containing deubiquitinase (DUB) module to the rest of the SAGA complex; regulates DUB module specificity (PubMed:24493646, PubMed:31348003). Important for regulating deubiquitination of histone 2B by SAGA (PubMed:24493646). The SAGA complex predominantly acetylates histone H3 (PubMed:30559249). Important regulator of transcription during embryogenesis; required for nuclear anchoring and cellularization (PubMed:28887412). Tethering the DUB module prevents not/non-stop from stabilizing SCAR, preventing its ability to promote actin polymerization (PubMed:31348003).
(UniProt, Q9VQB6)
Summary (Interactive Fly)

a subunit of SAGA chromatin remodeling complex - anchors Non-stop, a deubiquitinase, to the complex - Non-stop, dissociatedfrom Atxn7, interacts with Arp2/3 and WAVE regulatory complexes (WRC), which control actin - cytoskeleton assembly - Loss ofAtaxin-7 reduces H2B ubiquitination and leads to neural and retinal degeneration - expandable poly(Q) region close to theN-terminus - mammalian homolog contributes crucially to spinocerebellar ataxia pathogenesis by the induction of intranuclear inclusion bodies

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Atxn7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VQB6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atxn7-RA
FBtr0077765
NM_134833
3618
971
Atxn7-RB
FBtr0077766
NM_164481
3232
971
Atxn7-RC
FBtr0331437
NM_001273003
3655
971
Atxn7-RD
FBtr0331438
NM_001273004
3380
971
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Atxn7-PA
FBpp0077445
104.2
971
6.97
Q9VQB6
NP_608677
AAF51260
Atxn7-PB
FBpp0077446
104.2
971
6.97
Q9VQB6
NP_722803
AAN10428
Atxn7-PC
FBpp0303854
104.2
971
6.97
Q9VQB6
NP_001259932
AGB92469
Atxn7-PD
FBpp0303855
104.2
971
6.97
Q9VQB6
NP_001259933
AGB92470
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

971 aa isoforms: Atxn7-PA, Atxn7-PB, Atxn7-PC, Atxn7-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex consisting of wda/Taf5L, Saf6, Taf9, Taf10b, Taf12, Ada1, Spt3, Spt7, Spt20, Sf3b3, Sf3b5, Nipped-A/Tra1, a histone acetyltransferase (HAT) module made up of Gcn5, Ada2b (Isoform B), Ada3 and Sgf29, and a deubiquitinase (DUB) module made up of not/nonstop, Sgf11 and e(y)2 tethered to SAGA by Atxn7 (PubMed:20008933, PubMed:21764853, PubMed:24493646, PubMed:30559249). Untethered DUB module (DUBm) composed of not/nonstop, Sgf11 and e(y)2 remains enzymatically active (PubMed:24493646).

(UniProt, Q9VQB6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atxn7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.71

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Weake et al., 2011)
located_in polytene chromosome
inferred from direct assay
(Mohan et al., 2014)
part_of SAGA complex
inferred from direct assay
(Mohan et al., 2014, Weake et al., 2011)
part_of SAGA-type complex
inferred from direct assay
(Weake et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atxn7 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atxn7
Transgenic constructs containing regulatory region of Atxn7
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7011
(Ryder, 2004.4.26)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\ATXN7L1
1 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Atxn7l1
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Atxn7l1
1 of 14
Yes
Yes
Mmus\Atxn7
1 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\fhl1
1 of 13
Yes
No
Danio rerio (Zebrafish) (3)
Drer\atxn7
1 of 14
Yes
Yes
Drer\atxn7l2a
1 of 14
Yes
Yes
Drer\atxn7l2b
1 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006621
1 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SGF73
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sgf73
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Atxn7. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Atxn7KK110634
model of  spinocerebellar ataxia 7
is ameliorated by Hsap\ATXN7Q10.UAS.Tag:MYC
(Sujkowski et al., 2024)
is ameliorated by Hsap\ATXN7Q92.UAS.Tag:MYC
(Sujkowski et al., 2024)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Atxn7 - Ada1-2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014, Weake et al., 2009)
Atxn7 - Ada2b
anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, molecular sieving
(Mohan et al., 2014, Weake et al., 2011, Weake et al., 2009)
Atxn7 - Ada3
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - CG12054
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
(Rhee et al., 2014)
Atxn7 - Gcn5
anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Nipped-A
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Saf6
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014, Weake et al., 2009)
Atxn7 - Sf3b3
anti tag coimmunoprecipitation, peptide massfingerprinting
(Stegeman et al., 2016)
Atxn7 - Sf3b5
anti tag coimmunoprecipitation, peptide massfingerprinting
(Stegeman et al., 2016)
Atxn7 - Sgf11
anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Sgf29
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014, Weake et al., 2009)
Atxn7 - Spt20
anti tag coimmunoprecipitation, peptide massfingerprinting
(Stegeman et al., 2016, Mohan et al., 2014)
Atxn7 - Spt3
anti tag coimmunoprecipitation, peptide massfingerprinting
(Stegeman et al., 2016, Mohan et al., 2014)
Atxn7 - Spt7
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Taf10b
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Taf12
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - Taf9
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - e(y)2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014)
Atxn7 - not
anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
(Cloud et al., 2019, Mohan et al., 2014)
Atxn7 - wda
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2014, Weake et al., 2009)
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Component of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex consisting of wda/Taf5L, Saf6, Taf9, Taf10b, Taf12, Ada1, Spt3, Spt7, Spt20, Sf3b3, Sf3b5, Nipped-A/Tra1, a histone acetyltransferase (HAT) module made up of Gcn5, Ada2b (Isoform B), Ada3 and Sgf29, and a deubiquitinase (DUB) module made up of not/nonstop, Sgf11 and e(y)2 tethered to SAGA by Atxn7 (PubMed:20008933, PubMed:21764853, PubMed:24493646, PubMed:30559249). Untethered DUB module (DUBm) composed of not/nonstop, Sgf11 and e(y)2 remains enzymatically active (PubMed:24493646).
(UniProt, Q9VQB6 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-6
Cytogenetic map
22E1-22E1
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
22E1-22E1
Limits computationally determined from genome sequence between P{lacW}Rab5k08232 and P{PZ}dpp10638
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

2-6

(FlyBase, 2016)

2-4.7

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (7)
Genomic Clones (21)
cDNA Clones (17)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Mohan et al., 2014)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: Atxn7 CG9866

        (Mohan et al., 2014)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (7)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 43 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (37)