FlyBase Gene Report: Dmel\jet

General Information

Symbol

Dmel\jet

Species

D. melanogaster

Name

jetlag

Annotation Symbol

CG8873

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031652

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

jetlag (jet) encodes an F-box protein that is a component of an SCF E3 ubiquitin ligase complex. It targets the product of tim for degradation upon light exposure, and is essential for photic entrainment of the circadian clock. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

25B4-25B4

Sequence location

2L:4,948,206..4,949,784 [-]

Recombination map

2-14

RefSeq locus

NT_033779 REGION:4948206..4949784

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in entrainment of circadian clock by photoperiod

inferred from mutant phenotype

(Lamba et al., 2014, Koh et al., 2006)

involved_in locomotor rhythm

inferred from genetic interaction with FLYBASE:tim; FB:FBgn0014396

(Peschel et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

inferred from sequence model

(FlyBase Curators, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of SCF ubiquitin ligase complex

inferred from sequence model

(FlyBase Curators, 2011-)

Gene Group (FlyBase)

F BOX ONLY PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

F BOX ONLY PROTEINS -: F box only proteins (FBXO) are F box proteins which do not contain WD40 repeats or leucine-rich repeats, but may contain other domains. F box proteins are the variable substrate adapters for Skp, Cullin, F-box (SCF) E3 ubiquitin ligase complexes. (Adapted from FBrf0225076).

Summary (Interactive Fly)

an F-box protein with leucine-rich repeats (LRRs), a putative component of a SCF E3 ubiquitin ligase complex - essential for resetting the clock by transmitting light signals from Cryptochrome to Timeless resulting in the degredation of Timeless

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\jet for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VMY0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

jet-RA

FBtr0079057

NM_135036

1453

319

jet-RB

FBtr0110896

NM_001042867

1241

313

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

jet-PA

FBpp0078693

36.1

319

8.21

FBpp0110196

35.1

313

8.21

Q0E8T8

NP_001036332

ABI31287

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jet using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

jet_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.34

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jet in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\jet

View exonic expression by tissue for Dmel\jet

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33705/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031652

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031652

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031652

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8873

Flygut - An atlas of the Drosophila adult midgut

FBgn0031652

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of jet

Transgenic constructs containing regulatory region of jet

Aberrations (Deficiencies and Duplications) ( 8 )

Inferred from experimentation ( 8 )

Gene disrupted in

Df(2L)BSC51

(Koh et al., 2006)

Df(2L)Exel7021

(Koh et al., 2006, Ryder, 2004.4.26)

Df(2L)Exel8012

(Koh et al., 2006, Ryder, 2004.4.26)

(Koh et al., 2006)

(Koh et al., 2006)

(Koh et al., 2006)

(Koh et al., 2006)

(Koh et al., 2006)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

jet^GD14053

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

jet^GD14053

viable, with Scer\GAL4^tin.CΔ4

jet^GD14053

Other Phenotypes

Allele

abnormal locomotor rhythm | adult stage

jet^set

abnormal locomotor rhythm | adult stage, with Scer\GAL4^Dvir\Pdf.1.9

jet^JF01506

abnormal locomotor rhythm | adult stage, with Scer\GAL4^Mai179

jet^JF01506

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

jet^JF01506

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.PE

jet^JF01506

photoperiod response variant

some die during pupal stage, with Scer\GAL4^pnr-MD237

jet^GD14053

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\FBXL15

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Fbxl15

9 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Fbxl15

8 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (5)

Xtro\fbxl15

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (19)

Drer\fbxl15

10 of 14

Yes

Drer\fbxl6

2 of 14

Drer\fbxl7

2 of 14

Drer\si:ch73-173p19.1

2 of 14

Drer\si:dkey-192l18.9

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-214j8.12

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\T01E8.1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP009335

12 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (48)

Atha\AT3G58530

3 of 13

Yes

Atha\AT5G23340

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\SKP2B

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\AMN1

1 of 13

Yes

Scer\GRR1

1 of 13

Yes

Scer\RAD7

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pof2

1 of 12

Yes

Spom\rhp7

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:jet. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

CG32085

3 of 13

Fbxl7

3 of 13

Ppa

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FBXL15; F-box and leucine rich repeat protein 15

8 of 14

610287

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

jet - BRWD3

pull down, anti tag western blot

(Ozturk et al., 2013)

jet - SkpA

pull down, anti tag western blot

(Koh et al., 2006)

jet - cry

two hybrid, pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, molecular weight estimation by staining

(Ozcelik et al., 2024, Ozturk et al., 2014, Ozturk et al., 2013, Ozturk et al., 2011, Peschel et al., 2009)

jet - tim

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Peschel et al., 2009, Koh et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

jet|tim

enhanceable

cry

(Peschel et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031652

MIST (protein-protein) - An integrated Molecular Interaction Database

33705

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-14

Cytogenetic map

25B4-25B4

Sequence location

2L:4,948,206..4,949,784 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25B4-25B4

Limits computationally determined from genome sequence between P{lacW}l(2)k10004^k10004&P{EP}CG3036^EP963 and P{PZ}l(2)05714⁰⁵⁷¹⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-14

(FlyBase, 2016)

2-16.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27641

y¹ w^*; jet^r

27642

y¹ w^*; jet^c

31058

y¹ v¹; P{TRiP.JF01506}attP2

NIG-Fly

M2L-1057

y¹ w¹¹¹⁸; jet^SK3 P{neoFRT}40A/CyO-Tb

M2L-1058

y¹ w¹¹¹⁸; jet^SK4 P{neoFRT}40A/CyO-Tb

2LG-0500

y² VhaAC39-1^cho-1 v¹; P{U6-jet.NIG.sgRNA}attP40/CyO

VDRC

v104399

P{KK108329}VIE-260B

v45618

w¹¹¹⁸ P{GD14053}v45618

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD07444

Other clones

FI04015

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031652

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031652

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Encodes an F-box protein with leucine-rich repeats.

(Koh et al., 2007)

The jet product physically associates with the tim protein, and the association is stronger in light than in dark.

(Koh et al., 2007)

Mutations in jet result in reduced light sensitivity of the circadian clock: mutant flies show rhythmic behavior in constant light, reduced phase shifts in response to light pulses, and reduced light-dependent degradation of tim protein.

(Koh et al., 2007)

jet is required for light-induced degradation of the tim protein.

(Koh et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: jet CG8873

(Koh et al., 2006)

Nomenclature comments

Etymology

Named "jetlag" because mutants take longer to re-entrain to a new schedule than wild-type flies.

(Koh et al., 2006)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG8873

(National Institute of Genetics Fly Stocks, 2022-, Chen et al., 2019, Roberts et al., 2012, Keleman et al., 2009.8.5, Ni et al., 2008, Ho et al., 2006, Koh et al., 2006, Koh et al., 2006, Peschel et al., 2006)

FBXL15

(Roberts et al., 2012)

JET

(Ozturk, 2022, Srikanta and Cermakian, 2021, Tabuchi et al., 2021, Damulewicz and Mazzotta, 2020, Foley and Emery, 2020, Patke et al., 2020, Lin et al., 2018, Ganguly et al., 2016, Merbitz-Zahradnik and Wolf, 2015, Ozturk et al., 2014, Ozturk et al., 2013, Vaidya et al., 2013, Hara et al., 2011, Ozturk et al., 2011, Knowles et al., 2009, Koh et al., 2007)

JETLAG

(Mendoza-Viveros et al., 2017, Michael et al., 2017)

Jet

(Smith et al., 2026, Ozcelik et al., 2024, Mazzoccoli et al., 2016, Peschel and Helfrich-Förster, 2011)

Name Synonyms

CG8873

JETLAG

(Damulewicz and Mazzotta, 2020, Ozturk et al., 2013, Koh et al., 2007)

Jetlag

(Damulewicz and Mazzotta, 2025, Ganguly et al., 2016, Mazzoccoli et al., 2016, Ozturk et al., 2014, Ozturk et al., 2011, Tang et al., 2010, Knowles et al., 2009, Skaar et al., 2009)

jetlag

(Fischer et al., 2016, Peschel et al., 2009, Dolezelova et al., 2007, Koh et al., 2007, Koh et al., 2006, Peschel et al., 2006, Van Gelder, 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33705

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VMY0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VMY0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33705/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031652

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031652

FlyMine - An integrated database for Drosophila genomics

FBgn0031652

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8873

MARRVEL_MODEL - MARRVEL (model organism gene)

33705

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031652

DroID - A comprehensive database of gene and protein interactions.

FBgn0031652

DRSC - Results frm RNAi screens

FBgn0031652

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

jet_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031652

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031652

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8873

Flygut - An atlas of the Drosophila adult midgut

FBgn0031652

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

33705

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

0.34

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