FB2026_02 , released June 18, 2026
Gene: Dmel\Tsp
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General Information
Symbol
Dmel\Tsp
Species
D. melanogaster
Name
Thrombospondin
Annotation Symbol
CG11326
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031850
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

CT31613, SP295

Key Links
Genomic Location
Cytogenetic map
26F7-27A1
Sequence location
Recombination map
2-22
RefSeq locus
NT_033779 REGION:6686791..6709086
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables heparin binding
inferred from direct assay
(Adams et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables calcium ion binding
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in cell adhesion mediated by integrin
inferred from mutant phenotype
(Subramanian et al., 2007)
involved_in muscle organ development
inferred from mutant phenotype
(Subramanian et al., 2007)
involved_in somatic muscle attachment to chitin-based cuticle
inferred from mutant phenotype
(Chanana et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cell adhesion
inferred from electronic annotation with InterPro:IPR003367, InterPro:IPR008859
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in extracellular matrix
inferred from direct assay
(Adams et al., 2003)
is_active_in focal adhesion
inferred from direct assay
(Subramanian et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN000810635
(GO Reference Genome Project, 2011-)
located_in extracellular region
inferred from electronic annotation with InterPro:IPR008859
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons. [Date last reviewed: 2019-03-14]
Summary (Interactive Fly)

extracellular matrix ligand produced by tendon cells - essential for the formation of the integrin-mediated myotendinous junction - a ligand for the integrin subunit Inflated

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Tsp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM97)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tsp-RA
FBtr0079312
NM_078771
4227
1060
Tsp-RC
FBtr0079313
NM_164702
2135
419
Tsp-RD
FBtr0079311
NM_164703
2122
419
Tsp-RE
FBtr0079314
NM_164704
2112
419
Tsp-RF
FBtr0114488
NM_001144330
3892
1060
Tsp-RG
FBtr0114489
NM_001144331
2312
651
Tsp-RH
FBtr0336751
NM_001273219
2364
651
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tsp-PA
FBpp0078941
118.3
1060
4.60
Q9VM97
NP_523495
AAF52425
Tsp-PC
FBpp0078942
47.4
419
8.16
Q8T0I9
NP_723203
AAN10592
Tsp-PD
FBpp0078940
47.4
419
8.16
Q8T0I9
NP_723204
AAN10593
Tsp-PE
FBpp0078943
47.4
419
8.16
Q8T0I9
NP_723205
AAN10594
Tsp-PF
FBpp0112980
118.3
1060
4.60
Q9VM97
NP_001137802
ACL83008
Tsp-PG
FBpp0112981
72.2
651
4.06
B7Z030
NP_001137803
ACL83009
Tsp-PH
FBpp0307727
72.2
651
4.06
B7Z030
NP_001260148
AGB92684
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

419 aa isoforms: Tsp-PC, Tsp-PD, Tsp-PE
1060 aa isoforms: Tsp-PA, Tsp-PF
651 aa isoforms: Tsp-PG, Tsp-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.37

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
primordial germ cell
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11
trunk mesoderm anlage

Comment: tip

(Chanana et al., 2007)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal apodeme anlage
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
longitudinal trunk visceral muscle primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral apodeme anlage
(Fisher et al., 2012)
embryonic stage 13
embryonic epidermis

Comment: at segment borders excluding region over VNC

(Chanana et al., 2007)
proventriculus anlage
(Chanana et al., 2007)
embryonic stage 13 -- 16
embryonic central brain
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic proventriculus inner layer
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
longitudinal intestinal visceral muscle fiber
(Fisher et al., 2012)
embryonic stage 14
tendon cell of lateral transverse muscle cell
(Chanana et al., 2007)
embryonic stage 14 -- 17
tendon cell
(Chanana et al., 2007)
tendon cell of pharyngeal muscle cell
(Chanana et al., 2007)
Additional Descriptive Data

Tsp expression is observed in early blastoderm embryos. It is next observed at stage 11 in the trunk mesoderm primordium forming a ring like structure around the invaginating midgut and at the segment borders starting from the ventral region. From stage 13, strong expression is observed in the epidermis at segment borders excluding the region that covering ventral nerve cord. In addition, Tsp is transiently expressed in the primordium of the proventriculus. At stage 14 strong Tsp expression is observed in the developing tendon cells at the segment border and in the developing tendon cells of the lateral transverse muscles. Furthermore, Tsp is strongly expressed in the tendon cells of the pharyngeal muscles. From early stage 16 onward, Tsp expression persists in all tendon cells after muscle attachment including the ventral tendon cells covering the VNC. At late stage 16, Tsp expression is refined to the tendon cells that contact muscles.

(Chanana et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 16
tendon cell
(Subramanian et al., 2007)
Additional Descriptive Data

At stage 12-13, prior to the formation of muscle-tendon junctions, Tsp protein is detected as scattered dots around the sr-expressing tendon cells. At stage 16, following the establishment of the myotendinous junction, Tsp becomes highly concentrated at the muscle-tendon junction sites.

(Subramanian et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular matrix
inferred from direct assay
(Adams et al., 2003)
is_active_in focal adhesion
inferred from direct assay
(Subramanian et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tsp in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tsp
Transgenic constructs containing regulatory region of Tsp
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)Exel7027
(Ryder, 2004.4.26)
Tp(2;2)CA30
(Vorbrüggen, 2009.7.6)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (18)
Hsap\COMP
13 of 14
Yes
Yes
2  
Hsap\THBS3
12 of 14
No
Yes
Hsap\THBS4
12 of 14
No
Yes
Hsap\THBS1
7 of 14
No
Yes
Hsap\THBS2
6 of 14
No
Yes
Hsap\CRB2
1 of 14
No
No
6  
Hsap\EYS
1 of 14
No
No
1  
Hsap\FBLN2
1 of 14
No
No
1  
Hsap\ISM1
1 of 14
No
Yes
Hsap\LTBP2
1 of 14
No
No
Hsap\LTBP3
1 of 14
No
No
Hsap\NELL1
1 of 14
No
Yes
1  
Hsap\NELL2
1 of 14
No
Yes
Hsap\NID2
1 of 14
No
No
2  
Hsap\NOTCH1
1 of 14
No
No
Hsap\NOTCH2
1 of 14
No
No
Hsap\NOTCH3
1 of 14
No
No
Hsap\STAB2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Comp
13 of 14
Yes
Yes
Rnor\Thbs3
11 of 14
No
Yes
Rnor\Thbs4
11 of 14
No
Yes
Rnor\Thbs2
7 of 14
No
Yes
Rnor\Thbs1
5 of 14
No
Yes
Rnor\Fbln2
2 of 14
No
No
Rnor\Crb1
1 of 14
No
No
Rnor\Fat4
1 of 14
No
No
Rnor\Ltbp2
1 of 14
No
No
Rnor\Nell2
1 of 14
No
Yes
Rnor\Nid2
1 of 14
No
No
Rnor\Notch3
1 of 14
No
No
Mus musculus (laboratory mouse) (12)
Mmus\Comp
13 of 14
Yes
Yes
Mmus\Thbs3
12 of 14
No
Yes
Mmus\Thbs4
12 of 14
No
Yes
Mmus\Thbs2
7 of 14
No
Yes
Mmus\Thbs1
6 of 14
No
Yes
Mmus\Fbln2
2 of 14
No
No
Mmus\Crb2
1 of 14
No
No
Mmus\Ism1
1 of 14
No
Yes
Mmus\Nell2
1 of 14
No
Yes
Mmus\Nid1
1 of 14
No
No
Mmus\Nid2
1 of 14
No
No
Mmus\Notch3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\comp
7 of 13
Yes
Yes
Xtro\thbs4
6 of 13
No
Yes
Xtro\thbs3
5 of 13
No
Yes
Xtro\thbs1
3 of 13
No
Yes
Xtro\thbs2
3 of 13
No
Yes
Xtro\cfap206
1 of 13
No
No
Xtro\egfl6
1 of 13
No
Yes
Xtro\mras
1 of 13
No
Yes
Xtro\ncoa1
1 of 13
No
No
Xtro\nell2
1 of 13
No
No
Xtro\notch1
1 of 13
No
No
Xtro\notch2
1 of 13
No
No
Xtro\npnt
1 of 13
No
Yes
Xtro\stab2
1 of 13
No
No
Xtro\tnni1.2
1 of 13
No
No
Danio rerio (Zebrafish) (28)
Drer\thbs3b
13 of 14
Yes
Yes
Drer\comp
12 of 14
No
Yes
Drer\thbs3a
12 of 14
No
Yes
Drer\thbs4a
12 of 14
No
Yes
Drer\thbs4b
12 of 14
No
Yes
Drer\thbs1b
8 of 14
No
Yes
Drer\thbs2a
8 of 14
No
Yes
Drer\thbs2b
7 of 14
No
Yes
Drer\thbs1a
5 of 14
No
Yes
Drer\crb2a
1 of 14
No
No
Drer\crb2b
1 of 14
No
No
Drer\eys
1 of 14
No
No
Drer\fbn2a
1 of 14
No
No
Drer\hmcn1
1 of 14
No
No
Drer\ism1
1 of 14
No
Yes
Drer\ism2a
1 of 14
No
Yes
Drer\ism2b
1 of 14
No
Yes
Drer\jag1b
1 of 14
No
No
Drer\jag2b
1 of 14
No
No
Drer\LOC100535166
1 of 14
No
Yes
Drer\nell2b
1 of 14
No
No
Drer\nid1a
1 of 14
No
No
Drer\nid2a
1 of 14
No
No
Drer\notch1a
1 of 14
No
No
Drer\notch1b
1 of 14
No
No
Drer\notch2
1 of 14
No
No
Drer\notch3
1 of 14
No
No
Drer\tenm1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\clec-78
1 of 14
Yes
No
Cele\cubn-1
1 of 14
Yes
No
Cele\F14H12.3
1 of 14
Yes
Yes
Cele\glp-1
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP002157
11 of 12
Yes
Yes
Agam\AgaP_AGAP001015
1 of 12
No
No
Agam\AgaP_AGAP010335
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Tsp. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
N
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    TspUAS.AD.cSa
    ameliorates  muscular dystrophy
    modeled by Scgδ840
    (Vanhoutte et al., 2016)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    COMP; cartilage oligomeric matrix protein
    13 of 14
    600310
     
    THBS3; thrombospondin 3
    12 of 14
    188062
        THBS4; thrombospondin 4
        12 of 14
        600715
            THBS1; thrombospondin 1
            7 of 14
            188060
                THBS2; thrombospondin 2
                6 of 14
                188061
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please see the Physical Interaction reports below for full details
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Tsp - slow
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Gilsohn and Volk, 2010)
                  Summary of Genetic Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Tsp
                  enhanceable
                  fon
                  (Green et al., 2016)
                  Tsp
                  enhanceable
                  if
                  (Chanana et al., 2007)
                  Tsp
                  enhanceable
                  LanB2
                  (Wolfstetter and Holz, 2012)
                  Tsp
                  enhanceable
                  mew
                  (Chanana et al., 2007)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  if
                  enhanceable
                  Tsp
                  (Chanana et al., 2007)
                  mew
                  enhanceable
                  Tsp
                  (Chanana et al., 2007)
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  FlyBase
                  External Links
                  External Data
                  Linkouts
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Class of Gene
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2L
                  Recombination map
                  2-22
                  Cytogenetic map
                  26F7-27A1
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  26F7-27A1
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  26F6-27A1
                  (Adolph, 2000.9.15)
                  27A1-27A2
                  (Serano, 1999.12.13)
                  Experimentally Determined Recombination Data
                  Location

                  2-22

                  (FlyBase, 2016)

                  2-21.6

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (20)
                  Genomic Clones (24)
                  cDNA Clones (67)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Subramanian et al., 2007)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      The Tsp gene product is essential for muscle adhesion to the tendon cell through association with muscle-specific integrin receptors.

                      (Subramanian et al., 2007)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: Tsp SP295

                      (Adams et al., 2003)
                      Additional comments

                      Source for identity of thrombospondin CG11326 was sequence comparison ( date:010530 ).

                      (FlyBase, 1996-)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Tsp CG11326

                      (Adolph, 2001)

                      Source for identity of: thrombospondin CG11326

                      (FlyBase, 1996-)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (11)
                      Reported As
                      Symbol Synonym
                      CG11326
                      (National Institute of Genetics Fly Stocks, 2022-, Rosa-Ferreira et al., 2015, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Subramanian et al., 2005, Borras et al., 2003, Adolph, 2001, Giannakou and Dow, 2001)
                      CT31613
                      (Ceriani et al., 2002, Hynes and Zhao, 2000)
                      D-TSP
                      (Adams et al., 2003)
                      DTSP
                      (Adolph, 2001)
                      DmTSP
                      (Tucker and Adams, 2024)
                      SP295
                      (Adams et al., 2003)
                      TSP
                      (Li et al., 2025, Hughes and Jacobs, 2017)
                      Tsp
                      (Bischoff et al., 2025, Tu et al., 2025, Pignataro et al., 2024, Parisi et al., 2023, Liu et al., 2022, Anqueira-González et al., 2021, Baker et al., 2021, Dubey et al., 2020, Liu et al., 2020, Mira and Morante, 2020, Parra and Johnston, 2020, Daniel et al., 2018, Lee et al., 2018, Pérez-Moreno et al., 2017, Transgenic RNAi Project members, 2017-, Valdivia et al., 2017, Gene Disruption Project members, 2016-, Green et al., 2016, Ng et al., 2016, Vanhoutte et al., 2016, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Weitkunat and Schnorrer, 2014, Japanese National Institute of Genetics, 2012.5.21, Napoletano et al., 2011, Rebeiz et al., 2011, Wertheim et al., 2011, Deng et al., 2010, Gilsohn and Volk, 2010, Fujikawa et al., 2009, Vorbrüggen, 2009.7.6, Bharucha et al., 2008, Subramanian et al., 2007, Wijnen et al., 2006)
                      tsp
                      (Ikmi et al., 2014, Wolfstetter and Holz, 2012, Zhang et al., 2008, Chanana et al., 2007, Subramanian et al., 2005)
                      Name Synonyms
                      Thrombospondin
                      (Liu et al., 2020, Pérez-Moreno et al., 2017, Gilsohn and Volk, 2010, Vorbrüggen, 2009.7.6, Gilsohn and Volk, 2008, Subramanian et al., 2007, Adolph, 2001)
                      thrombospondin
                      (Chanana et al., 2007)
                      Secondary FlyBase IDs
                      • FBgn0029130
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 79 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (98)