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FB2026_01
,
released March 12, 2026
d-mtDNA helicase, mtDNA helicase, Twinkle
Please see the JBrowse view of Dmel\mtDNA-helicase for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Homohexamer (via C-terminus) which assembled in a ring-like structure. Homoheptamer which assembled in a ring-like structure. Oligomerization is Mg(2+), nucleotide and DNA-independent, however, Mg(2+) and nucleotide stabilize the homohexameric form.
N-terminus enhances protein stability and hexamer formation, which is important for DNA binding, and is required for DNA helicase activity and, ultimately, for mtDNA replisome processivity.
The N-terminal primase-like domain (NTD) is made up of two regions named zinc-binding domain (ZBD) and RNA-polymerase domain (RPD) due to homology to T7 gp4 (PubMed:25023283). Instead of binding zinc the ZBD coordinates binding of a
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mtDNA-helicase using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\mtDNA-helicase in JBrowse2-37
2-32.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-unspecified : A stable S2 cell line expressing the N-terminal, primase-like domain (NTD) of mtDNA-helicase (amino acids Met1-Ala333), C-terminally tagged with His was generated.
New stable cell line derived from S2-unspecified : Inducible stable S2 cell lines were created expressing mtDNA-helicase, one of four deletion mutations of mtDNA-helicase, or one of eight mtDNA-helicase variants carrying the alanine substitutions K574A, R576A, Y577A, D580A, E587A, F588A, K590A, and Y595A.
Source for identity of: mtDNA-helicase CG5924
