FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\PICK1
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General Information
Symbol
Dmel\PICK1
Species
D. melanogaster
Name
Protein interacting with C kinase 1
Annotation Symbol
CG6167
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032447
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
33F3-33F3
Sequence location
Recombination map
2-47
RefSeq locus
NT_033779 REGION:12695033..12698917
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables membrane curvature sensor activity
inferred from sequence or structural similarity with UniProtKB:Q9NRD5
(Herlo et al., 2018)
enables phospholipid binding
inferred from biological aspect of ancestor with PANTHER:PTN000951698
(GO Reference Genome Project, 2011-)
inferred from sequence model
(Jansen et al., 2009)
enables protein domain specific binding
inferred from electronic annotation with InterPro:IPR010504
(InterPro Project Members, 2004-)
enables protein kinase C binding
inferred from biological aspect of ancestor with PANTHER:PTN000951685
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in cellular response to sucrose stimulus
inferred from expression pattern
(Holst et al., 2013)
involved_in positive regulation of developmental growth
inferred from mutant phenotype
(Holst et al., 2013)
involved_in regulated exocytosis
inferred from expression pattern
(Jansen et al., 2009)
involved_in regulation of postsynapse organization
inferred from mutant phenotype
(Mallik et al., 2017)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in dendritic spine maintenance
inferred from biological aspect of ancestor with PANTHER:PTN000254194
(GO Reference Genome Project, 2011-)
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN000254123
(GO Reference Genome Project, 2011-)
involved_in positive regulation of receptor internalization
inferred from biological aspect of ancestor with PANTHER:PTN000951685
(GO Reference Genome Project, 2011-)
involved_in receptor clustering
inferred from biological aspect of ancestor with PANTHER:PTN000951685
(GO Reference Genome Project, 2011-)
involved_in regulation of Arp2/3 complex-mediated actin nucleation
inferred from biological aspect of ancestor with PANTHER:PTN000254123
(GO Reference Genome Project, 2011-)
involved_in regulation of insulin secretion
inferred from sequence or structural similarity with UniProtKB:Q9NRD5
(Herlo et al., 2018)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in neuronal cell body
inferred from direct assay
(Jansen et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000254194
(GO Reference Genome Project, 2011-)
is_active_in postsynaptic density
inferred from biological aspect of ancestor with PANTHER:PTN000254194
(GO Reference Genome Project, 2011-)
is_active_in synaptic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000254194
(GO Reference Genome Project, 2011-)
is_active_in trans-Golgi network membrane
inferred from biological aspect of ancestor with PANTHER:PTN000951698
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\PICK1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry X2JDZ1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
PICK1-RA
FBtr0080395
NM_135738
1694
504
PICK1-RB
FBtr0080396
NM_165018
1932
487
PICK1-RD
FBtr0340542
NM_001298951
1639
487
PICK1-RE
FBtr0340543
NM_001298952
1913
577
PICK1-RF
FBtr0340544
NM_001259080
1865
487
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
PICK1-PA
FBpp0079976
56.6
504
4.60
Q8SY07
NP_609582
AAF53213
PICK1-PB
FBpp0079977
54.5
487
4.78
Q86PF5
NP_723766
AAN10821
PICK1-PD
FBpp0309441
54.5
487
4.78
Q86PF5
NP_001285880
AHN54394
PICK1-PE
FBpp0309442
64.4
577
4.58
X2JDZ1
NP_001285881
AHN54395
PICK1-PF
FBpp0309443
54.5
487
4.78
Q86PF5
NP_001246009
AFH03683
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

487 aa isoforms: PICK1-PB, PICK1-PD, PICK1-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PICK1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.91

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval corpus cardiacum
(Jansen et al., 2009)
neuron of larval brain | restricted
(Jansen et al., 2009)
neuron of larval ventral nerve cord | restricted
(Jansen et al., 2009)
adult stage
neuron of adult brain | punctate | restricted
(Jansen et al., 2009)
adult pars intercerebralis | restricted
(Jansen et al., 2009)
adult gnathal ganglion | restricted
(Jansen et al., 2009)
adult antennal lobe | dorso-lateral | ventral
(Jansen et al., 2009)
cell body rind of adult gnathal ganglion | restricted
(Jansen et al., 2009)
cell body rind of adult antennal lobe | restricted
(Jansen et al., 2009)
neurosecretory cell of pars intercerebralis
(Holst et al., 2013)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Jansen et al., 2009)
Additional Descriptive Data

PICK1 staining shows partial overlap with Ilp2 staining, but mostly clusters around zones of high Ilp2 immunoreactivity.

(Holst et al., 2013)

PICK1 protein is expressed in neurons in the adult and larval brain, ventral nerve cord and corpus cardiacum. Some neurons labeled by PICK1 in the ventral and dorsolateral antennal lobe co-express ScerGAL4Gad1.3.098. The largest cells in the adult brain that express PICK1, located near the medial border of the optic lobe, dorsolateral protocerebrum and dorsomedially on each side of the pars interecerebralis, co-express ScerGAL4dimm-929. There is also co-expression in the larval brain and ventral nerve cord between PICK1 and ScerGAL4dimm-929. Most PICK1 positive neurons are also labeled by ScerGAL4Phm.WT and ScerGAL4Ilp2.PR.

(Jansen et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in neuronal cell body
inferred from direct assay
(Jansen et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PICK1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of PICK1
Transgenic constructs containing regulatory region of PICK1
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\PICK1
13 of 14
Yes
Yes
Hsap\ARFIP1
1 of 14
No
No
Hsap\ARFIP2
1 of 14
No
No
0  
Hsap\DLG4
1 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Pick1
13 of 14
Yes
Yes
Rnor\Arfip1
1 of 14
No
No
Rnor\Arfip2
1 of 14
No
No
Rnor\Dlg4
1 of 14
No
No
Rnor\Dlg5
1 of 14
No
No
Rnor\Ptpn13
1 of 14
No
No
Rnor\Whrn
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Pick1
12 of 14
Yes
Yes
Mmus\Arfip1
1 of 14
No
No
Mmus\Arfip2
1 of 14
No
No
Mmus\Dlg4
1 of 14
No
No
Mmus\Dlg5
1 of 14
No
No
Mmus\Sntg1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\pick1
8 of 13
Yes
Yes
Xtro\arfip1
1 of 13
No
No
Danio rerio (Zebrafish) (4)
Drer\pick1
13 of 14
Yes
Yes
Drer\arfip1
1 of 14
No
No
Drer\arfip2a
1 of 14
No
No
Drer\arfip2b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\Y57G11C.22
13 of 14
Yes
Yes
Cele\F54C8.7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP007832
11 of 12
Yes
Yes
Agam\AgaP_AGAP004910
1 of 12
No
No
Agam\AgaP_AGAP006627
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:PICK1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
Arfip
3 of 13
Tfb1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PICK1; protein interacting with PRKCA 1
    13 of 14
    605926
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-47
        Cytogenetic map
        33F3-33F3
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        33F3-33F3
        Limits computationally determined from genome sequence between P{lacW}bunk00612&P{EP}EP682EP682 and P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-47

        (FlyBase, 2016)

        2-42.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (18)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (108)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Jansen et al., 2009)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Identification: Yeast two hybrid screen for interactors with gcl.

              (Dockendorff and Jongens, 2004)

              Subcellular location is dynamic; PICK1 co-localizes with gcl during development.

              (Dockendorff and Jongens, 2004)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: PICK1 CG6167

              (Dockendorff, 2004.3.4)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 51 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (40)