FlyBase Gene Report: Dmel\Mocs2B

General Information

Symbol

Dmel\Mocs2B

Species

D. melanogaster

Name

Molybdenum cofactor synthesis 2B

Annotation Symbol

CG10238

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039280

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Mocs2, dMoaE

Key Links

Genomic Location

Cytogenetic map

96C1-96C1

Sequence location

3R:25,125,632..25,127,359 [-]

Recombination map

3-87

RefSeq locus

NT_033777 REGION:25125632..25127359

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables molybdopterin synthase activity

inferred from sequence or structural similarity with HGNC:7193

(Suganuma et al., 2012)

inferred from sequence or structural similarity with UniProtKB:O96007

(assigned by UniProt )

(UniProt Curators, 2002-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from direct assay

(Suganuma et al., 2008)

involved_in histone acetylation

inferred from direct assay

(Suganuma et al., 2008)

involved_in molybdopterin cofactor biosynthetic process

inferred from mutant phenotype

(Marelja et al., 2018)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in Mo-molybdopterin cofactor biosynthetic process

inferred from sequence or structural similarity with HGNC:7193

(Suganuma et al., 2012)

inferred from sequence or structural similarity with UniProtKB:O96007

(assigned by UniProt )

(UniProt Curators, 2002-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of Ada2/Gcn5/Ada3 transcription activator complex

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

inferred from direct assay

(Suganuma et al., 2012)

part_of molybdopterin synthase complex

inferred from direct assay

(Suganuma et al., 2012)

located_in polytene chromosome

inferred from direct assay

(Nagy et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000600812

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:O96007

(assigned by UniProt )

(UniProt Curators, 2002-)

Gene Group (FlyBase)

ATAC COMPLEX

SULFURTRANSFERASES

Protein Family (UniProt)

Belongs to the MoaE family. MOCS2B subfamily. (Q9VBX2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ATAC COMPLEX -: The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
SULFURTRANSFERASES -: Sulfurtransferases catalyze the transfer of sulfur-containing groups.

Protein Function (UniProtKB)

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group.

(UniProt, Q9VBX2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mocs2B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2008)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mocs2B-RA

FBtr0084782

NM_143083

1420

367

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Mocs2B-PA

FBpp0084157

41.9

367

8.47

NP_651340

AAF56405

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterotetramer; composed of 2 small (Mocs2A) and 2 large (Mocs2B) subunits (By similarity). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268).

(UniProt, Q9VBX2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VBX2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mocs2B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mocs2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Ada2/Gcn5/Ada3 transcription activator complex

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

inferred from direct assay

(Suganuma et al., 2012)

part_of molybdopterin synthase complex

inferred from direct assay

(Suganuma et al., 2012)

located_in polytene chromosome

inferred from direct assay

(Nagy et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mocs2B in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mocs2B

View exonic expression by tissue for Dmel\Mocs2B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039280

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039280

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10238-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10238

Flygut - An atlas of the Drosophila adult midgut

FBgn0039280

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mocs2B

Transgenic constructs containing regulatory region of Mocs2B

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation

Gene partially disrupted in

Df(3R)Mocs2-Δ21A

(Grabbe, 2018.6.28)

Df(3R)Mocs2-Δ28A

(Grabbe, 2018.6.28)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mocs2B^GD6913

viable, with Scer\GAL4^Mef2.PR

Mocs2B^GD6913

viable, with Scer\GAL4^pnr-MD237

Mocs2B^GD6913

viable, with Scer\GAL4^tin.CΔ4

Mocs2B^GD6913

Other Phenotypes

Allele

abnormal circadian behavior, with Scer\GAL4^cry.PZ

Mocs2B^KK101263

abnormal circadian behavior, with Scer\GAL4^tim.PE

Mocs2B^KK101263

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MOCS2

10 of 15

Yes

Hsap\MBIP

2 of 15

Yes

Hsap\NMRK1

1 of 15

Hsap\NMRK2

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Mocs2

10 of 15

Yes

Mmus\Mbip

2 of 15

Yes

Mmus\Nmrk1

1 of 15

Mmus\Nmrk2

1 of 15

Rattus norvegicus (Norway rat) (2)

Rnor\Mocs2

6 of 13

Yes

Rnor\Mbip

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\mocs2

6 of 12

Yes

Xtro\LOC105945135

1 of 12

Yes

Xtro\mbip

1 of 12

Yes

Xtro\nmrk2

1 of 12

Danio rerio (Zebrafish) (4)

Drer\LOC103911725

1 of 15

Yes

Drer\LOC110437854

1 of 15

Yes

Drer\nmrk1

1 of 15

Yes

Drer\nmrk2

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\nmrk-1

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G43760

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\NRK1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBP22H7.06

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AMK )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10181

Drosophila persimilis

Dper\GL21938

Drosophila willistoni

Dwil\GK13883

Drosophila virilis

Dvir\GJ23609

Drosophila mojavensis

Dmoj\GI23778

Drosophila grimshawi

Dgri\GH19575

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D3Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018327

Musca domestica

House fly

Mdoa\17019323

Glossina morsitans

Tsetse fly

Gmor\GMOY011496

Glossina morsitans

Tsetse fly

Gmor\GMOY011491

Glossina morsitans

Tsetse fly

Gmor\GMOY011552

Mayetiola destructor

Hessian fly

Mdes\Mdes003504

Aedes aegypti

Yellow fever mosquito

Aaeg\Mocs2-1

Aedes aegypti

Yellow fever mosquito

Aaeg\Mocs2-2

Anopheles darlingi

American malaria mosquito

Adar\ADAC007003

Anopheles gambiae

Malaria mosquito

Agam\Mocs2

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FRR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004876

Danaus plexippus

Monarch butterfly

Dple\DPOGS204024-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004957

Apis florea

Little honeybee

Aflo\2267202932

Apis mellifera

Western honey bee

Amel\GB48674

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14067

Bombus terrestris

Buff-tailed bumblebee

Bter\15216477

Linepithema humile

Argentine ant

Lhum\LH18759

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0026f0

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003105

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05749

Tribolium castaneum

Red flour beetle

Tcas\TC009192

Pediculus humanus

Human body louse

Phum\PHUM458240

Pediculus humanus

Human body louse

Phum\PHUM458250

Rhodnius prolixus

Kissing bug

Rpro\RPRC003918

Rhodnius prolixus

Kissing bug

Rpro\RPRC012291

Cimex lectularius

Bed bug

Clec\CLEC011681

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003595

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05124

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FRW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013055

Ixodes scapularis

Black-legged tick

Isca\ISCW009709

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g09313

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_199098

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CV5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mocs2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mbip

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022996

Ciona intestinalis

Vase tunicate

Cint\LOC100183606

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000010096

Gallus gallus

Domestic chicken

Ggal\MOCS2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MOCS2; molybdenum cofactor synthesis 2

model of molybdenum cofactor deficiency type B

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MOCS2; molybdenum cofactor synthesis 2

10 of 15

603708

MOLYBDENUM COFACTOR DEFICIENCY, COMPLEMENTATION GROUP B; MOCODB

molybdenum cofactor deficiency type B

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Mocs2B

pull down, anti tag western blot

(Suganuma et al., 2012)

Mocs2B - Ada2a

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, molecular sieving

(Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Ada3

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Atac1

anti tag coimmunoprecipitation, western blot, experimental knowledge based, peptide massfingerprinting

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Atac2

anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving, western blot, experimental knowledge based

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Atac3

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - CG31974

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2016)

Mocs2B - CG7366

experimental knowledge based

(Guruharsha et al., 2011)

Mocs2B - Chrac-14

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - D12

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, molecular sieving, experimental knowledge based

(Suganuma et al., 2016, Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Gcn5

anti tag coimmunoprecipitation, western blot, molecular sieving, experimental knowledge based, peptide massfingerprinting

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Hcf

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, experimental knowledge based

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - Jra

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - MBD-R2

experimental knowledge based

(Guruharsha et al., 2011)

Mocs2B - Mkk4

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - Mocs2A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2016)

Mocs2B - NC2β

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Mocs2B - PolE4

experimental knowledge based

(Guruharsha et al., 2011)

Mocs2B - Rcd1

experimental knowledge based

(Guruharsha et al., 2011)

Mocs2B - ReepA

experimental knowledge based

(Guruharsha et al., 2011)

Mocs2B - Sgf29

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, experimental knowledge based, peptide massfingerprinting

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Weake et al., 2009, Suganuma et al., 2008)

Mocs2B - Slik

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - Uba4

anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot

(Suganuma et al., 2012)

Mocs2B - Uba5

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2016, Suganuma et al., 2012)

Mocs2B - blanks

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2016)

Mocs2B - chic

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - lic

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - msn

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010)

Mocs2B - wds

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Suganuma et al., 2010, Suganuma et al., 2008)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9VBX2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67937

DroID - A comprehensive database of gene and protein interactions.

FBgn0039280

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43017

MIST (protein-protein) - An integrated Molecular Interaction Database

Mocs2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Molybdenum cofactor biosynthesis

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-87

Cytogenetic map

96C1-96C1

Sequence location

3R:25,125,632..25,127,359 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96C1-96C1

Limits computationally determined from genome sequence between P{lacW}OstStt3^j2D9 and P{PZ}Aats-gln⁰⁵⁴⁶¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-87

(FlyBase, 2016)

3-85.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

58058

y¹ v¹; P{TRiP.HMJ21913}attP40

31813

w¹¹¹⁸; P{EP}Mocs2B^G16540 Mocs2A^G16540/TM6C, Sb¹

44196

y¹ w^*; Mi{MIC}Mocs2B^MI07531 Mocs2A^MI07531/TM3, Sb¹ Ser¹

78833

w^*; P{?EP}Mocs2-Δ1A, Mocs2A^Δ1A Mocs2B^Δ1A/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹

78834

w^*; Df(3R)Mocs2-Δ21A, Mocs2A^Δ21A Mocs2B^Δ21A/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹

78835

w^*; Df(3R)Mocs2-Δ28A, Mocs2A^Δ28A Mocs2B^Δ28A/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹

FlyORF

F003517

M{UAS-Mocs2B.ORF.3xHA.GW}ZH-86Fb

Kyoto

140045

y^* w^*; P{FRT(w^hs)}2A P{neoFRT}82B PBac{SAstopDsRed}Mocs2B^LL00220 P{Car20y}96E / TM3, Sb¹

VDRC

v106248

P{KK101263}VIE-260B

v15990

w¹¹¹⁸; P{GD6913}v15990/TM3

v318694

PBac{fTRG00855.sfGFP-TVPTBF}VK00002

v342572

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02283}attP40/CyO-GFP

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH02855

Other clones

DPiM_GH02855

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039280

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039280

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43017

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Suganuma et al., 2012, Suganuma et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Mocs2 CG10238

(Hayden and Bosco, 2008)

Source for identity of: Mocs2B Mocs2

(Marelja et al., 2018)

Source for database merge of

Additional comments

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42503 and CG10238.

(FlyBase Genome Annotators, 2008)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43017

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VBX2

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039280

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039280

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mocs2_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10238

Flygut - An atlas of the Drosophila adult midgut

FBgn0039280

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43017

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009192

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10238

modMine - A data warehouse for the modENCODE project

FBgn0039280

Linkouts

BioGRID - A database of protein and genetic interactions.

67937

DPiM - Drosophila Protein interaction map

FBgn0039280

DroID - A comprehensive database of gene and protein interactions.

FBgn0039280

DRSC - Results frm RNAi screens

FBgn0039280

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039280

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10238-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039280

FlyMine - An integrated database for Drosophila genomics

FBgn0039280

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43017

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Mocs2

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Molybdenum cofactor biosynthesis

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG10238

(Hosono et al., 2015, Spedale et al., 2012, Suganuma et al., 2012, Furrer et al., 2010, Nagy et al., 2010, Ni et al., 2010.12.1, Suganuma et al., 2010, Keleman et al., 2009.8.5, Weake et al., 2009, FlyBase Genome Annotators, 2008, Hayden and Bosco, 2008, Suganuma et al., 2008)

Dromel_CG10238_FBtr0084782_mocs_mORF

(Hayden and Bosco, 2008)

MBIP/dMoaE

(Suganuma et al., 2012)

MOCS2

(Hayden and Bosco, 2008)

Mbip

(Spedale et al., 2012)

Mocs2

(Fowler et al., 2019, Marelja et al., 2018, Otto et al., 2018, Sarov et al., 2016, Carvalho et al., 2015, FlyBase Genome Annotators, 2008)

Mocs2B

(Grabbe, 2018.6.28, Marelja et al., 2018)

dMbip

(Spedale et al., 2012)

dMoaE

(Suganuma et al., 2016, Suganuma et al., 2012)

Name Synonyms

CG10238

MAPK upstream kinase-binding inhibitory protein

(Spedale et al., 2012)

MUK-binding inhibitory protein

(Spedale et al., 2012)

Molybdenum cofactor synthesis 2

Molybdenum cofactor synthesis 2B

Molybdopterin synthase 2

molybdopterin synthase 2

(Hayden and Bosco, 2008)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (52)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections